The Center for Immunology is an interdisciplinary research program at the University of Minnesota devoted to advancing the field of immunology and educating future immunologists.
Autoimmunity • Cancer • Vaccines • Cures
Wondering about COVID-19 research and news...
Milcah Scott is awarded a Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship
CFI would like to congratulate Milcah Scott, a predoctoral student in the Masopust Lab. Milcah was awarded the Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship for her work on a suite of contemporary and complementary whole animal, cellular and molecular approaches to better define the transcriptional programs and phenotypes of stringently-identified, bona fide tissue resident memory CD8 T cells (TRM). Refined analyses of TRM will broaden our understanding of how TRM are generated and maintained in tissues and are key to addressing deficiencies in our understanding of how (TRM) effect pathogen protection, tumor control, and autoimmune pathogenesis. The purpose of the Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship award is to enable promising predoctoral students to obtain individualized, mentored research training from outstanding faculty sponsors while conducting dissertation research in scientific health-related fields to enhance the individual’s potential to develop into a productive, independent research scientist.
Binstadt Lab is hiring a new Post Doctoral Fellow
The Binstadt Lab in the University of Minnesota’s Center for Immunology seeks a new post-doctoral
fellow. This individual will work together with our team to explore mechanisms of cardiovascular
inflammation in the setting of systemic autoimmunity.
Applicants must hold a Ph.D. degree in biological science and have a recent track record of publication
of first-author peer-reviewed manuscripts.
● Preference will be given to applicants with Ph.D. degrees in Immunology (particularly
Autoimmunity) and/or expertise in Vascular Biology, particularly the role of inflammation in the
● Experience working with small animal models, flow cytometry, immunofluorescent microscopy,
and analysis of transcriptomic data (e.g. scRNASeq) or similar large datasets is preferred.
● Preference will be given to applicants with demonstrated expertise in developing scientific
protocols, scientific writing, and outstanding letters of reference.
Please apply online using job code 340404. Also, email a curriculum vitae and a cover letter to Bryce
Binstadt, MD, Ph.D. Fujob description here
Congratulations to Dr. JT Greene for his American Cancer Society postdoctoral fellowship
J.T. Greene, Ph.D. from the Freedman labthe American Cancer Society to support his ongoing research and training. The Cancer Society awards researchers who are within 3 years of receiving a doctoral degree initial funding to start training for an independent career in cancer research. J.T. was also awarded The Ben G. Zimmerman Travel Award from the Department of Pharmacology, this award supports the participation (poster or oral presentation) of graduate students and postdoctoral trainees at scientific conferences.
Mike Farrar and Brian Fife are funded to study antigen-specific T cells in diabetes
CFI professors' Michael Farrar, professor, and Virginia and David C. Utz Land Grant Chair in Fundamental Immunobiology, LMP and Brian Fife, associate professor of Medicine, recently received a five-year $590,000 grant from the National Institute of Allergy and Infectious Diseases (NIAID) for “Identifying and preventing antigen-specific T cells in diabetes.”
Join REJUS and EWIS for our monthly discussions on race and gender inequality!!
Securing your Zoom meeting
Marc Jenkins elected to the National Academy of Sciences and AAI awards him their highest honor: The Lifetime Achievement Award!
AAI bestows their highest honor the Lifetime Achievement Award to Dr. Marc Jenkins
The American Association of Immunologists (AAI) has bestowed their highest honor on Dr. Marc Jenkins. The 2020-21 Lifetime Achievement Awardhere. CFI would like to extend our congratulations and thank Dr. Jenkins for his guidance and leadership as well as the inspiration he inspires as a teacher, mentor, and scientist to those not only at our University but worldwide. The Virtual IMMUNOLOGY2021™ was held May 10–15, if you missed the awards presentation, click here
CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model
The Stromnes lab was recently awarded an RO1 based on the work led by Dr. Adam Burrack. His recent first author J. Immunol and Cell Report papers have identified a mechanistic basis for T cell exhaustion in pancreatic cancer and a feasible clinical strategy to overcome it.
Expansible residence decentralizes immune homeostasis
While working on his doctoral thesis in the Masopust lab, Sathi Wijeyesinghe found that expansibility and tissue residency are generalizable qualities that underlie immune homeostasis, building on our initial exploration of resident memory T cell durability and maintenance, his "story" can be read in the March 2021 edition of Nature.
MHC class II tetramers engineered for enhanced binding to CD4 improve detection of antigen-specific T cells.
T cell memory: Understanding COVID-19As the SARS-CoV-2 pandemic has progressed, increasing attention has focused on establishing natural and vaccine-induced immunity against this coronavirus and the disease, COVID-19, that it causes. In the 2021 preprint issue of Immunity, Jarjour, Masopust and Jameson explain the fundamental features of T cell memory and their potential relevance for effective immunity to SARS-CoV-2. Read here
Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression
A study published in Nature Immunology which was led by Jesse Williams has formed new answers regarding atherosclerosis, the build-up of fats, cholesterol and other substances in and on the artery walls. Read here.
Thymic regulatory T cells arise via two distinct developmental programs
The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self-antigens and non-self antigens remain unclear. Here the Farrar lab et al. found that mature Treg cells were generated through two distinct developmental programs involving CD25+ Treg cell progenitors and Foxp3lo Treg cell progenitors (Foxp3lo TregP cells). Read more
Research ethics at the University of Minnesota
Global Gophers: Health and Wellness Webinar
Thurs. Seminars: Aug. 5
LSSURP Poster Symposium
9:30am – 11:30am|McNamara Alumni Center
Federal Resume Writing
1pm – 2pm|Register here
Friday Seminars: Aug. 6