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The Center for Immunology is an interdisciplinary research program at the University of Minnesota devoted to advancing the field of immunology and educating future immunologists.

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Register now for the AAI 2017 Advanced Course in Immunology.  This intensive course features several leading experts including our own David Masopust presenting recent advances in understanding the biology of the immune system and its role in health and disease.  Deadline to register is June 30, 2017. View the course schedule.

 

 

Thanks to everyone who participated in The March for Science

EWIS at MfS

On April 22, 2017, a group of CFI and EWIS members from the University of Minnesota joined over 10,000 other Minnesotans to march on the state capitol to show support of higher education and the discovery, access, and understanding of scientific information. The march was to remind everyone that we are working to protect and defend science funding, regulatory agencies, and evidence based policy-making in recognition that science plays a vital role in the progress and sustainability of society.

 

 

Nathan Schuldt, Ph.D. has been named one of the AAI 2017-18 Public Policy Fellows

 nathan sAAI has launched the seventh year of its Public Policy Fellows Program (PPFP), which engages postdoctoral fellows and junior scientists in public policy activities that impact biomedical research. Each year 10 fellows from across the United States are selected by the AAI Committee on Public Affairs. Congratulations to Nathan Schuldt, a post doctoral fellow in the Bindstadt Lab.  Nathan was chosen as one of the ten 2017-2018 fellows and is looking forward to learning more about how biomedical research policies are shaped and how he can serve as a better advocate for scientific research.

 

 

In an April 2017 Nature Immunology article, Farrar and colleagues propose a potential strategy for inhibiting progenitor B cells from becoming cancerous.

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A research team led by Michael FarrarProfessor and Utz Chair in Fundamental Immunobiology, investigated transcription factor networks as prognostic markers of disease severity.  They report their findings in “Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival” published in Nature Immunology.

In earlier studies Farrar identified the transcription factor STAT5 as key to the transformation of progenitor B cells into leukemic cells, though the underlying mechanism for transformation was unclear.  In the newly published paper he and colleagues identify regulatory competition between STAT5 and the transcription factors IKAROS and NF-κB.  The STAT5 interaction with the IKAROS - NF-κB network serves as a “molecular switch” governing the proliferation, survival and differentiation of progenitor B cells.  The authors found that high regulatory imbalance between these antagonistic transcription-factor networks serves as a marker for severe disease and poor response to therapy.  They propose that addressing the regulatory imbalance is a potential strategy for inhibiting progenitor B cells from becoming cancerous.

 

More center news

  • Co-housing with pet store mice changes the immune system of laboratory mice

    In this April 20, 2016 issue of Nature, Lalit Beura, Sara Hamilton, Marc Jenkins, Vaiva Vezys, Steve Jameson, Dave Masopust, et.al. show evidence of how laboratory rodents can skew immunology research but that "dirty mice" can clean up the results. Read more

  • Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns

    In this February 2016 Nature Immunology article, Deepali Malhotra, T. Dileepan, You Jeong Lee, Brian Fife, Kris Hogquist, Marc Jenkins, et.al. explain how tolerance mechanisms identified in eGFp-expressing mouse strains govern tolerance to true self antigens. Read more

  • Tumor specific T cells interacting with B16 Tumor cells& CD11c YFP DCs, courtesy of Brian Fife and Jason Mitchell

    Jason Mitchell and Brian Fife show Tumor specific T cells (red and green) interacting with B16 Tumor cells (blue) and CD11c YFP DCs (yellow)

  • Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.

    In this June 2016 Nature Communications article Justin Spanier, Dmitri Kotov, Marc Jenkins, Brian Fife, et al show that after infection with Listeria monocytogenes expressing 2W and W6 antibody treatment, 2W-specific cells were magnetically enriched from the spleen of C57Bl6 mice. Read More

  • Regulated activation of TGF-b by stromal cells can directly control epithelial residence of cells of the immune system through a novel mechanism of intercellular communication.

    Javed Mohammed, Dave Masopust, Lalit Beura, Emily Thompson and Dan Kaplan, et al, report that UV irradiation promotes Langerhans cell migration through diminished integrin expression and TGF-b activation. Read More

  • Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival

    In Nature Immunology, April 2017, Casey Katerndahl, Lynn Heltemes-Harris and Michael Farrar, et.al. identify that the activation of STAT5 acts in synergy with pre-BCR signaling defects to deregulate the expression of NF-κB target genes. Read More

  • Michael Farrar, PhD

    Professor, Laboratory Medicine and Pathology

  • William Schmalstieg, MD

    Assistant Professor, Neurology

  • Erik J. Peterson, MD

    Associate Director, UMN Dept. of Medicine Physician Scientist Training Program; Associate Professor, Medicine

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    Tea and Talk!!

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    May 22

    Immunology Journal Club
    Lee Meier-Binstadt Lab

    "Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure"

    10:00-11:30 a.m. | 1-125 CCRB


    May 23

    Infection and Immunity Research Conference

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    "Influenza C surveillance in Minnesota"
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    "Trends in pricing and manufacturers for the oral antibiotic market"

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    May 31

    Surgical Transplant Conference

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