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The Center for Immunology is an interdisciplinary research program at the University of Minnesota devoted to advancing the field of immunology and educating future immunologists.

Autoimmunity Cancer Vaccines Cures

  • Naive B Cells with High-Avidity Germline-EncodedAntigen Receptors Produce Persistent IgM+andTransient IgG+Memory B Cells

    Immune memory often lasts for life, this is not the case for certain vaccines in some individuals. By studying B cell responses to phycoerythrin, in the June 2018 issue of Immunity, Pape et al. find that memory B cell responses can be shortlived when generated from precursors that experience unusually strong early signals of avid antigen binding via germline-encoded VH elements. Read more

  • Beura, Et Al, Nature Immunology paper 19,173-182 (2018)

    Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory

    Using two-photon intravital microscopy to visualize the responses of CD8resident memory T cells (Trm cells), Post Doctoral fellows in Masopust, Vezys, and Fife labs found that the Trm cells were highly motile but would pause and undergo in situ division after antigen challenge. Read more

  • Co-housing with pet store mice changes the immune system of laboratory mice

     Nature  highlights the work of Lalit Beura, Sara Hamilton, Marc Jenkins, Vaiva Vezys, Steve Jameson, Dave Masopust, et.al. and their evidence of how laboratory rodents can skew immunology research but that "dirty mice" can clean up the results. Read more

  • Thymic regulatory T cells arise via two distinct developmental programs

    The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self-antigens and non-self antigens remain unclear. Here the Farrar lab et al. found that mature Treg cells were generated through two distinct developmental programs involving CD25+ Treg cell progenitors and Foxp3lo Treg cell progenitors (Foxp3lo TregP cells). Read more 

  • Chrysalis: A New Method for High-Throughput Histo-Cytometry Analysis of Images and Movies

    Advances in imaging have led to the development of powerful multispectral, quantitative imaging techniques, like histo-cytometry. The utility of this approach is limited, however, by the need for time-consuming manual image analysis. In an effort to address the time issue, Kotov and Pengo et al. created the software Chrysalis along with a suite of Imaris Xtensions to batch image processing and analysis to automate the processing workflow for confocal, epi-fluorescence, and two-photon microscopy images. Read more

     

  • Dual TCR T Cells: Identity Crisis or Multitaskers?

    In this study, Drs. Binstadt and Schuldt aim to provide a brief but comprehensive history of dual TCR T cell research, re-evaluate past observations in the context of current knowledge of the immune system, and identify key issues for future study. Read More

 

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RED Seminars



Dr. David Masopust received the 2019 Dean's Distinguished Research Lectureship 

dave The annual Dean’s Distinguished Research Lectureship honors up to two outstanding faculty members who are selected to share their research stories which detail the state of the science when they entered the field, changes that emerged due to their work, and plans or predictions for the future of medicine and basic science research. On Wednesday, November 13, 2019, Dr. David Masopust and Dr. Melissa Geller were honored along with the Wall of Scholarship Honorees. To read more about the event: click here or to watch the event: click here

 

The UMN Impact of Medicine Series showcases Dr. Marc Jenkins 

Marc 2019 
Considered to be one of the countries high performing medical school, the University of Minnesota believes that promoting and rewarding a culture of excellence is key in maintaining high standards. One way of displaying specifically how we impact medicine is to showcase those who exemplify the mission. This month Dr. Marc Jenkins was showcased, in an interview about how he has sought and discovered answers about our world through science.  For the full interview and video, link here.

 

 

5 Pi's-Jenkins, Jameson, Hogquist, Fife, Mueller

Since 1993, the National Institute of Allergy and Infectious Diseases (NIAID) has awarded Investigators within the Center for Immunology the ability to examine CD4 and CD8 T cell tolerance mechanisms at the cellular and molecular levels. The program project is titled "Mechanisms of Peripheral Induction of T-cell Tolerance" and the program which is led by Dr. Kris Hogquist includes five projects that will focus on distinct but complementary aspects of tolerance: natural MHCII-bound self epitope discovery, polyclonal anergic cells, type I interferons, non-deletional CD8+ T cell tolerance, and hybrid self-peptides. The relevance of this project focuses on the mechanisms of immune tolerance, with hopes that the results of these studies could lead to new methods for diagnosing diabetes and monitoring immunotherapy. The Center for Immunology would like to congratulate the Jenkins, Jameson, Hogquist, Fife and Mueller labs on their continued success as they start another 5 years of research on developing an increased understanding of T cell tolerance for the prevention or treatment of autoimmune diseases.

 


Dr. Borges da Silva awarded an NIH Pathway to Independence Award

HenriqueCFI would like to congratulate Dr. Henrique Borges da Silva from the Jameson lab, he has been awarded an NIAID research grant to support his work. This fellowship aims to harness a strong cohort of new NIH-supported independent investigators. K99/R00 awardees receive support for independent projects and facilitate their transition to tenure-track or equivalent faculty positions. Henrique will work on the project: "Defining the function of extracellular ATP sensing for memory CD8+ T cell generation and longevity", and will seek to better understand how the "danger signal" eATP controls the long-term establishment of CD8 T cell memory.

 

CFI's Alex Khoruts is quoted by NBC News 

Alex KOn October 24, 2019, NBC news quoted Dr. Alex Khoruts in regards to how sun exposure can affect your microbiome. Here is the full NBC article, to read more about Dr. Khorut's own work with FMTs click here for an interview done by Steve LeBeau for the magazine Global Advances in Health and Medicine.

 

 

The Center for Immunology proudly hosted its first-ever Alumni Celebration

ThanksOn Thursday, April 18, 2019, the Center for Immunology hosted its first Alumni Celebration. The event welcomed over 100 current faculty and students, alumni, professors and more. We were especially happy to welcome Drs. David Brown, Gus Dalmasso, Paul Quie and John Crosson who made special trips to campus just for the occasion of the reunion. At the event, the Robert A. Good Door was presented (see photos) and will be hung at the Center for Immunology.  Drs. Marc Jenkins and Matt Mescher also announced the creation of a new fund to enhance the student experience within the Center. The Mescher Trainee Enhancement fund, an endowed fund, will live in perpetuity at the University of Minnesota and will be available to the Center for Immunology's students. The fund will help with costs like conference registration and travel, equipment and technology, emergency needs and other expenses which can make all the difference in training the next generation of scientists.  To date, $60,000 has been raised with a goal of $100,000. If you were interested in making a gift, and have not done so yet - or were unable to attend the event but still want to support the CFI while honoring Dr. Mescher -visit the fund here. You may also contact Sarah Barsness at the University of Minnesota Foundation if you'd like to make a gift using your IRA, estate plans, donor-advised fund, or other means of charitable giving. Sarah's contact information is 612-625-5976 or sbarsnes@umn.edu. Please click here to see all the great pictures taken at the event!

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Research ethics at the University of Minnesota

We are committed to protecting research participants, upholding ethical standards, and improving our practice at every step of our work.

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Announcements


U of MN Faculty

every Monday and Thursday

2:30 p.m. | 2-163 WMBB
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November 18

Immunology Journal Club
Upasana Arvindam-Miller Lab

9:00-10:00 a.m.| 2-115 CCRB
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MICaB-Immunology Invited Speaker Seminar
Luis Martinez-Sobrido, Ph.D.
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY

“In vivo reverse genetics”

12:00-1:00 p.m.| 1-125 CCRB
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Rheumatology Special Seminar
Meena Madhur, MD, PhD
Assistant Professor, Medicine, Divisions of Clinical Pharmacology and Cardiology, Vanderbilt University

“Hypertension and the Maladaptive Immune Response.”

1:45-2:45 p.m.| 1-125 CCRB
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November 19

Cancer Center Seminar Series
Dipak Panigrahy, MD, PhD
Beth Israel Deaconess Medical Center, Harvard University

"Cancer Progression: Failure of Resolution of Inflammation and Tumor Debris?"

9:00-10:00 a.m. | 1-125 CCRB
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Infection and Immunity Research Conference
**next meeting held on Dec. 10, 2019**

12:00-1:00 p.m.| 1-101 MRF
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November 20

Immunology Supergroup
Open

1:30-2:30 p.m. | 1-125 CCRB
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November 21

MICaB Student Seminar Series
Upasana Arvindam

“Improving NK cell function in the solid tumor micro environment”

12:00-1:00 p.m.| 1-110 LRB/MTRF
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November 25

Immunology Journal Club
Holiday-No Seminar

9:00-10:00 a.m.| 2-115 CCRB
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MICaB-Immunology Invited Speaker Seminar
Holiday-No Seminar

12:00-1:00 p.m.| 1-125 CCRB
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November 26

Cancer Center Seminar Series
Holiday-No Seminar

9:00-10:00 a.m. | 1-125 CCRB
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Infection and Immunity Research Conference
**next meeting held on Dec. 10, 2019

November 27

Immunology Supergroup
Holiday-No Seminar

1:30-2:30 p.m. | 1-125 CCRB
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November 28

MICaB Student Seminar Series
Holiday-No Seminar

12:00-1:00 p.m.| 1-110 LRB/MTRF
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If you are writing and need a quiet place to gather your thoughts, we have a spot for you.

See Annette Bethke, 2-142 WMBB to check out the office key.