The Center for Immunology is an interdisciplinary research program at the University of Minnesota devoted to advancing the field of immunology and educating future immunologists.
Autoimmunity • Cancer • Vaccines • Cures
CFI welcomes our newest faculty member, Michael Lipscomb, PhD
The Center for Immunology is thrilled to welcome Michael Lipscomb, PhD to the University of Minnesota and to our group housed in WMBB where he will have a satellite lab as part of his larger lab housed in NHH. Dr. Lipscomb is an Associate Professor in the Department of Pharmacology. He received his BS from the University of California Los Angeles with a degree in Microbiology, Immunology, and Molecular Genetics prior to receiving a Ph.D. in Immunology from the University of Pittsburgh. His postdoctoral training was at the University of Pennsylvania and Children’s Hospital of Philadelphia. Prior to coming to the University of Minnesota, Dr. Lipscomb held a faculty position at Howard University where he built a productive, visible, and independent research program studying immunobiology, with concentrations in immunoregulation, autoimmunity, immunology of infectious disease, and employment of biomaterials and microcarrier systems for organoid tissue development. The focus of his laboratory at the University of Minnesota is to mechanistically describe the immunoregulatory network(s) that govern the differentiation and function of antigen-presenting myeloid cells both under steady-state and disease settings. In addition, his laboratory employs the use of novel biomaterials to generate organoids for tissue restorative therapies, with the chief aim to resolve chronic autoimmune disorders and immunodeficiencies. Dr. Lipscomb is currently funded by the Maximizing Investigator Research Award (MIRA; R35 mechanism) and an R21 exploratory research grant. Dr. Lipscomb is also serving as the interim Associate Dean for Graduate Education. One of the goals of the Medical School during this transition period will be to step back and examine the existing graduate education program in the context of the current issues facing graduate and postdoctoral programs nationwide to see where we can strengthen and enhance those things that are working well. Stop by his office in Nils Hasselmo Hall 3-108 to visit and introduce yourself. For more info, click here.
Kris Hogquist is elected to the National Academy of Sciences
Congratulations to Dr. Harry Orr, 2022 recipient of the Kavli Prize in Neuroscience
The Kavli Foundation and the Norwegian Ministry of Education and Research announced June 1, 2022 that LMP professor Harry Orr is one of four winners of the 2022 Kavli Prize in Neuroscience. Named after Fred Kavli, a Norwegian-American physicist, entrepreneur and philanthropist, the biennial Kavli Prize “honors scientists for breakthroughs in astrophysics, nanoscience and neuroscience – transforming our understanding of the big, the small and the complex.” Orr was honored for his pioneering genetic research on the neurodegenerative disease spinocerebellar ataxia type 1 (SCA1), a collaborative effort with Baylor College of Medicine’s Huda Zogbhi, also a 2022 Kavli Prize winner. He will travel to Norway to receive the prize from Haakon, Crown Prince of Norway, in September. Each Kavli Prize consists of a gold medal, a scroll, and a cash award of $1 million, which is shared among the winners in each category. Congratulations Harry! Read more here.
Spring has been a busy time for CFI members:
Dr. Jesse Williams was awarded an NIH R01 grant "Sex and stress hormones control adrenal gland macrophage development and function" and a MN Department of Health grant to study monocyte trafficking following traumatic brain injury.
Dr. Matouš Vobořil, a postdoctoral fellow in the Hogquist lab, has been awarded a CRI Irvington Postdoctoral Fellowship.
Natalie David, MSTP/MICaB graduate student in the Farrar Lab was awarded the 2022 President’s Student Leadership & Service Award (PSLSA), this award recognizes the accomplishments and contributions of outstanding student leaders for their service to the University of Minnesota Twin Cities and the surrounding community.
Monica Sauer, BMBB graduate student in the Freedman Lab has been awarded the 2022 Armstrong-Pothapragada Graduate Fellowship by the Department and Graduate Program in Biochemistry, Molecular Biology & Biophysics. "This fellowship is given to a talented student who is in good standing and shows potential in their chosen field."
Dr. Ingunn Stromnes, received an R01 from National Cancer Institute entitled, "Enhancing engineered T cell therapeutic efficacy for the treatment of pancreatic ductal adenocarcinoma". (Co-Investigators are Drs. Stephen Shen, Xavier Revelo, Beau Webber). She also received one of the first Idea Awards from the Department of Defense for pancreatic cancer research entitled : “Manipulating Myeloid Cells to Promote Immunotherapy Efficacy of Pancreatic Ductal Adenocarcinoma" (Co-Investigators are Drs. Jesse Williams and Kaylee Schwertfeger)
Dr. Nicholas Maurice, a postdoc inStephen Jameson’s lab, was awarded a one-year grant from the National Cancer Institute (NCI) to study his proposal “Profiling and leveraging bystander T cells within the tumor microenvironment.”
Congratulations to everyone!!
CFI debuts new “CFI Legends Wall”
Recently a new wall of recognition was added to the Center for Immunology. To commemorate over 25 years of outstanding research, CFI is honoring two of the founding members of the Center for Immunology, Drs. Tucker LeBien and Matthew Mescher. Dr. LeBien was instrumental in revitalizing immunology as a discipline at the University of Minnesota. After the hiring of a prominent immunologist, Dr. Matthew Mescher in 1993, both LeBien and Mescher worked together to organize all of the UMN immunologists from several departments throughout the medical school. Once organized the group of 11 other faculty members formed a new graduate program to enhance the visibility of training opportunities in immunology. Mescher then applied for grants to establish contiguous research space and in 1995 the official Center for Immunology was launched. Mescher was named the first CFI director and continued to lead the center until 2013 when he stepped down. LeBien continued to support the CFI at an administrative level as the Vice Dean for Research in the Medical School and Associate Vice President for Research in the Academic Health Center until his retirement in January 2022. CFI is thrilled to begin the wall with two strong leaders. Stop by the 2nd floor WMBB to see the beautiful tributes to each of the legends.
Join AIRE and EWIS for our monthly discussions on race and gender inequality!!
Securing your Zoom meeting
Enhanced CD4+ and CD8+ T cell infiltrate within convex hull defined pancreatic islet borders as autoimmune diabetes progresses
Nature's Scientific Reports, August 25, 2021 issue has an article by Alex Dwyer in the Fife lab on a new process to identify islet damage where he introduces an automated convex hull-based analytical procedure using a macro written in FIJI for inflammation. This new tool could elevate inflammation for diabetes assessment and inflammation in general. Read more here: https://z.umn.edu/72ty
CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model
The Stromnes lab was recently awarded an RO1 based on the work led by Dr. Adam Burrack. His recent first author J. Immunol and Cell Report papers have identified a mechanistic basis for T cell exhaustion in pancreatic cancer and a feasible clinical strategy to overcome it.
Expansible residence decentralizes immune homeostasis
While working on his doctoral thesis in the Masopust lab, Sathi Wijeyesinghe found that expansibility and tissue residency are generalizable qualities that underlie immune homeostasis, building on our initial exploration of resident memory T cell durability and maintenance, his "story" can be read in the March 2021 edition of Nature.
MHC class II tetramers engineered for enhanced binding to CD4 improve detection of antigen-specific T cells.
T cell memory: Understanding COVID-19As the SARS-CoV-2 pandemic has progressed, increasing attention has focused on establishing natural and vaccine-induced immunity against this coronavirus and the disease, COVID-19, that it causes. In the 2021 preprint issue of Immunity, Jarjour, Masopust and Jameson explain the fundamental features of T cell memory and their potential relevance for effective immunity to SARS-CoV-2. Read here
Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression
A study published in Nature Immunology which was led by Jesse Williams has formed new answers regarding atherosclerosis, the build-up of fats, cholesterol and other substances in and on the artery walls. Read here.
Research ethics at the University of Minnesota
Mondays and Thursdays
2:00-2:30pm| 2-163 WMBB
COVID-19 Scientific Daily Update________________________
Mon. Seminars: Nov. 28
MICaB-Immunology Invited Speaker Seminar
"The intersection of cellular transcription and retrovirus assembly"
12:00-1:00pm|1-125 CCRB| Zoom
CFI Tea and Talk Time
calendarfor all info/events
Charles R. Rogers, Ph.D, MPH, MS, MCHES®
Associate Professor, Institute for Health & Equity
MCW Cancer Center
9-10 am|1-125 CCRB| Zoom
Center for Inflammation Science Seminar Series
“How macrophages return organs to homeostasis in infections, acute injury and chronic disease”
Paul Kubes, PhD
Professor, Department of Physiology & Pharmacology and Medicine
Lead: VPR Strategic Research Priority – Infections Inflammation and Chronic Diseases
University of Calgary
2pm – 3pm|Register
Wed. Seminars: Nov. 30
"Resident Cardiac Macrophages and Myocardial Remodeling"
Kory Lavine, M.D., Ph.D.
Associate Professor of Medicine
Returns Nov. 30
Thurs. Seminars: Dec. 1
“Functional genomics of polymicrobialinteractions and uncharacterized genes in Gram-positive bacteria”
Julia Willett, Ph.D., Department of Microbiology and Immunology, MICaB Graduate Faculty Candidate
Faculty Advocate: Ryan Hunter
12:00-1:00 p.m.|1-125 CCRB|Zoom
11am – 12pm|Register
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