The Center for Immunology is an interdisciplinary research program at the University of Minnesota devoted to advancing the field of immunology and educating future immunologists.
Autoimmunity • Cancer • Vaccines • Cures
Naive B Cells with High-Avidity Germline-EncodedAntigen Receptors Produce Persistent IgM+andTransient IgG+Memory B Cells
Immune memory often lasts for life, this is not the case for certain vaccines in some individuals. By studying B cell responses to phycoerythrin, in the June 2018 issue of Immunity, Pape et al. find that memory B cell responses can be shortlived when generated from precursors that experience unusually strong early signals of avid antigen binding via germline-encoded VH elements.
Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory
Using two-photon intravital microscopy to visualize the responses of CD8+ resident memory T cells (Trm cells), Post Doctoral fellows in Masopust, Vezys, and Fife labs found that the Trm cells were highly motile but would pause and undergo in situ division after antigen challenge. Read more
Co-housing with pet store mice changes the immune system of laboratory mice
Nature highlights the work of Lalit Beura, Sara Hamilton, Marc Jenkins, Vaiva Vezys, Steve Jameson, Dave Masopust, et.al. and their evidence of how laboratory rodents can skew immunology research but that "dirty mice" can clean up the results Read more
Thymic regulatory T cells arise via two distinct developmental programs
The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self-antigens and non-self antigens remain unclear. Here the Farrar lab et al. found that mature Treg cells were generated through two distinct developmental programs involving CD25+ Treg cell progenitors and Foxp3lo Treg cell progenitors (Foxp3lo TregP cells). Read more
Chrysalis: A New Method for High-Throughput Histo-Cytometry Analysis of Images and Movies
Advances in imaging have led to the development of powerful multispectral, quantitative imaging techniques, like histo-cytometry. The utility of this approach is limited, however, by the need for time-consuming manual image analysis. In an effort to address the time issue, Kotov and Pengo et al. created the software Chrysalis along with a suite of Imaris Xtensions to batch image processing and analysis to automate the processing workflow for confocal, epi-fluorescence, and two-photon microscopy images.
Dual TCR T Cells: Identity Crisis or Multitaskers?
Drs. Vezys and Bhela awarded the 2019 Careers in Immunology Fellowship
Drs. Vaiva Vezys and Siddheshvar Bhela have been awarded an AAI Careers in Immunology Fellowship Program elopment of young scientists by providing eligible PIs with one year of salary support for a trainee in their lab. Postdoctoral trainee, Dr. Sid Bhela will receive salary support for his work on the regulatory function of tolerant CD8+ T cells. Congratulations to both Drs. Vezys and Bhela.
Dr. Ingunn Stromnes awarded the 2019 Julia Stagliano Pancreatic Cancer Action Network Catalyst Grant
Congratulations to Dr. Ingunn Stromnes. Dr. Stromnes was awarded the 2019 Julia Stagliano Pancreatic Cancer Action Network Catalyst Grant for her research project "Overcoming Immunotherapy Resistance in Pancreas Cancer". "I am incredibly honored to receive support from the Pancreatic Cancer Action Network for funding our research to develop safe and effective immunotherapies for pancreas cancer," said Stromnes. "My team is also enormously grateful for the generosity of Nancy Stagliano, who in memory of Julia Stagliano, supports pancreas cancer immunotherapy research." The Pancreatic Cancer Action Network (PanCAN)2019 research grants.
Dr. Steve Jameson is elected to the AAI Council
CFI would like to extend our congratulations to Dr. Steve Jameson. Dr. Jameson has been elected to th2019-2023 AAI Council
Empowering Women in Science (EWIS) celebrates a year filled with achievements
Dr. Marc Jenkins, director of the Center for Immunology, is named a University of Minnesota Regents Professor
The Center for Immunology would like to congratulate Dr. Marc Jenkins, who has been appointed a Regents Professor of the University of Minnesota. The Regents Professorship is the highest honor the University of Minnesota can bestow on its faculty. This program not only recognizes the national and international prominence of the faculty member, but it also acknowledges the exceptional contributions that havenews releaseherehave
The Center for Immunology proudly hosted its first-ever Alumni Celebration
Research ethics at the University of Minnesota
U of MN Faculty
Become a Member
every Monday and Thursday
2:30 p.m. | 2-163 WMBB
Immunology Journal Club
Hrishi Venkatesh-Farrar Lab
9:30-10:30 a.m.| 2-115 CCRB
"Ratiometric quorum sensing"
1:30-2:30 p.m. | 1-125 CCRB
4:00-5:00 p.m. | Surgery Conference Room, 11-157 PWB
Microbiology & Immunology Centennial Celebration
Event Program and RSVP here
8:00-6:00 p.m. | McNamara Alumni Center
Microbiology & Immunology Centennial Lunch & Poster Session
Student Poster Sessions
12:00-2:45 p.m. | CCRB Atrium
Looking for a place to write?
If you are writing and need a quiet place to gather your thoughts, we have a spot for you.
See Annette Bethke, 2-142 WMBB to check out the office key.