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The Center for Immunology is an interdisciplinary research program at the University of Minnesota devoted to advancing the field of immunology and educating future immunologists.

Autoimmunity Cancer Vaccines Cures

  • Naive B Cells with High-Avidity Germline-EncodedAntigen Receptors Produce Persistent IgM+andTransient IgG+Memory B Cells

    Immune memory often lasts for life, this is not the case for certain vaccines in some individuals. By studying B cell responses to phycoerythrin, in the June 2018 issue of Immunity, Pape et al. find that memory B cell responses can be shortlived when generated from precursors that experience unusually strong early signals of avid antigen binding via germline-encoded VH elements. Read more

  • Beura, Et Al, Nature Immunology paper 19,173-182 (2018)

    Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory

    Using two-photon intravital microscopy to visualize the responses of CD8resident memory T cells (Trm cells), Post Doctoral fellows in Masopust, Vezys, and Fife labs found that the Trm cells were highly motile but would pause and undergo in situ division after antigen challenge. Read more

  • Co-housing with pet store mice changes the immune system of laboratory mice

     Nature  highlights the work of Lalit Beura, Sara Hamilton, Marc Jenkins, Vaiva Vezys, Steve Jameson, Dave Masopust, et.al. and their evidence of how laboratory rodents can skew immunology research but that "dirty mice" can clean up the results. Read more

  • Cutting Edge: Dual TCRa Expression Poses an Autoimmune Hazard by Limiting Regulatory T cell Generation

    In cutting edge research performed by the students and Post Doctoral fellows in the labs of Fife, Hogquist and Binstadt the hypothesis that dual TCR expression can promote autoimmunity by limiting agonist selection of self-reactive thymocytes is revisited . Read more 

  • The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells

    In an article published July 2018 in Nature postdoctoral fellows in the Jameson and Masopust labs, Drs. Borges da Silva and Beura, et al. show that P2RX7 is required for the establishment, maintenance and functionality of long-lived central and tissue-resident memory CD8+ T cell populations in mic. Read more

  • CD8αα+ Intraepithelial Lymphocytes Arise from Two Major Thymic Precursors

    In an article published in Nature Immunology, Post Doctoral Fellows Ruscher and Lee from the Hogquist and Jameson lab wanted to better define the thymic IEL precursor, and were able to provide an important foundation for understanding the biology of CD8αα IELs. Read More

 

Latest News    

Dave Masopust is named the 2018 inductee into the AHC Academy for Excellence in Health Research

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The Center for Immunology would like to congratulate Dave Masopust as he is honored with the highest recognition of excellence in research by AHC faculty. The AHC Academy for Excellence in Health Research is given to members of the University community that have enhanced the research identity of the University of Minnesota on a national and international level.  Dave joins over 42 other faculty members from across the AHC who have been inducted into the Academy since 2003.

 

The Center for Immunology mourns the passing of Mike Murtaugh

murtaugh Mike Murtaugh, a professor of virology and immunology at the University of Minnesota College of Veterinary Medicine, passed away Tuesday, September 18, 2018, following a battle with pancreatic cancer, see the full write-up in the Star TribuneMurtaugh's research was based on molecular mechanisms of disease resistance focusing on the interaction of pigs with bacterial and, especially, viral pathogens. In recent years, Murtaugh had been credited with significant advances in fundamental porcine immunobiology, especially those that are related to immune protection and immunomodulation; porcine antiviral immunity, and molecular virology as a means to understand genetic diversity and immunological challenges of viral origins. As part of Mike's legacy, the UMN College of Veterinary Medicine, Dean Ames and Mike's colleagues have created a new Graduate Science fellowship which will benefit CVM graduate students for years to come. To donate, click here.  

Dr. Marc Jenkins, director of the Center for Immunology, is named a University of Minnesota Regents Professor

marc 180x200The Center for Immunology would like to congratulate Dr. Marc Jenkins, as he is bestowed one of the University of Minnesota's highest honors, the Regents Professorship. This program not only recognizes the national and international prominence of the faculty member, but it also acknowledges the exceptional contributions that have been made to the University through teaching, research, scholarship, creative work, and collaboration with others.
Dr. Jenkins exemplifies all the characteristics of a Regents Professor and is one of the world’s most distinguished immunologists. Dr. Jenkins will be honored at the Board of Regents meeting on Friday, September 14, 2018. 


Congratulations to Tijana Martinov, the 2018 Sharon L. Doherty Student Leadership award winner

tijuana 200x200Tijana Martinov, a Ph.D. candidate in the Fife lab, a leader of the Association of Multicultural Scientists, and an active member of the Career Development Committee within her graduate program was awarded the 2018 Sharon L. Doherty Award. This award is given to a University of Minnesota student who has demonstrated outstanding volunteer service concerning women's issues on campus or in the broader community. The Doherty Award was established in 1993 and honors the work of former doctoral student and University of Minnesota alumna, Sharon Doherty, whose exhaustive efforts led to the successful Commission on Women's Students Initiative and continued University commitment to programming for women students. Tijana will be awarded $1000, to be used in support of attendance at a national leadership conference. The award will be given at the annual Celebrating Changemakers event hosted by the Women's Center on October 11, 2018. Everyone is welcome to attend a short awards program and dessert reception at University Hall, McNamara Alumni Center from 4:00-6:00 pm, RSVP here

Kris Hogquist is named the Laboratory Medicine and Pathology Vice Chair for Research

kris H


Congratulations to Kris Hogquist who has been named the Department of Laboratory Medicine and Pathology's Vice Chair for Research. In this new role, Kris will serve as chair of the Research Advisory Committee (RAC), provide an avenue for peer review of grant applications, identify strategic initiatives to expand on the department’s existing research accomplishments and help support the chair’s research vision for the department. Read more...

 


CFI welcomes our newest faculty member, Tyler Bold, M.D., Ph.D.

TBold 150x187Tyler obtained his M.D./Ph.D. at New York University focusing on T cell immunology in tuberculosis with mentor Dr. Joel Ernst, he went on to do his postdoctoral research with Dr. Eric Rubin at Harvard University on genetic approaches to manipulate tuberculosis pathogenesis. As a physician-scientist who specializes in treating patients with infectious diseases, he completed clinical training at Brigham and Women’s Hospital and Massachusetts General Hospital. His research at the UMN will focus on using advanced genetic tools in Mycobacterium tuberculosis to understand the targets and mechanisms of protective immunity in tuberculosis, as well as novel methods by which the bacteria evade immune destruction. He seeks to exploit this information to guide efforts to produce an effective vaccine for this devastating infection. Tyler is thrilled to be returning to the Midwest to join the incredible community of scientists at the Center for Immunology. Stop by his office on the second floor of WMBB and introduce yourself.

CFI's Checkpoint Bikers finish Chainbreaker18 to raise money for cancer research

chainbreaker congrats The goal of the Chainbreaker bike-a-thon is to provide Masonic Cancer Center's doctors and researchers with the necessary resources to discover cures for all cancers with 100% of rider-raised dollars going directly to the cause. The 2nd Annual Chainbreaker took place August 10-12, 2018. This year, members from CFI and the Department of Microbiology and Immunology rode again. The peloton called Checkpoint Bikers is inspired by the immune checkpoint blockade therapy that has revolutionized the treatment of certain cancers.  This year the team has already raised over $25,000 but is aiming to exceed last year's total of $36,000. If you would like to donate to the peloton, click here.

 

More center news.                                                                                                             Meet our Faculty

Research ethics at the University of Minnesota

We are committed to protecting research participants, upholding ethical standards, and improving our practice at every step of our work.

Learn more about our commitment to research ethics 

Announcements


U of MN Faculty

every Monday and Thursday

2:30 p.m. | 2-163 WMBB
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October 15

Immunology Journal Club
Elise Breed-Hogquis lab

9:00-10:00 a.m. | 2-115 CCRB
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October 15

MICaB Invited Speaker Seminar
Sarah Stanley, Ph.D.
Department of Infectious Diseases and Vaccinology, University of California, Berkeley, CA

12:00-1:00 p.m.| 1-125 CCRB
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October 16

Cancer Center Seminar Series
Frank Cichocki PhD 
Assistant Professor of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota

"New insights into the development, function and metabolism of adaptive NK cells"

9:00-10:00 a.m. | 1-125 CCRB
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October 16

Infection and Immunity Research Conference
Adam Cheng-Graduate Fellow, CBS Biochem

"A Novel Mechanism of APOBEC3 Counteraction by γ-Herpes viruses"

12:00-1:00 p.m. | 2-224 CCRB (lunch provided)
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October 17

Immunology Supergroup
Fife Lab

1:30-3:00 p.m. | 1-101 MRF
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October 18

MICaB Student Seminar
Sathi Wijeyesinghe

“Homeostasis of the immune system in nonlymphoid tissues”

12:00-1:00 p.m. | 2-102 CMRR
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October 22

Immunology Journal Club
Langlois lab

9:00-10:00 a.m. | 2-115 CCRB 
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October 22

Immunology MICaB Invited Speaker Seminar
John Harty, Ph.D.
Department of Microbiology and Immunology, University of Iowa, Iowa City, IA

"Immunity to Liver-Stage Malaria"

12:00-1:00 p.m.| 1-125 CCRB
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October 23

Cancer Center Seminar Series
Andrew Venteicher, MD, PhD 
UPP-Department of Neurological Surgery Pittsburgh, PA
 

"Investigating cellular evolution and microenvironment in IDH mutant glioma using single cell RNA sequencing"

9:00-10:00 a.m. | 1-125 CCRB
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Looking for a place to write?

If you are writing and need a quiet place to gather your thoughts, we have a spot for you.

See Annette Bethke, 2-142 WMBB to check out the office key.