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The Center for Immunology is an interdisciplinary research program at the University of Minnesota devoted to advancing the field of immunology and educating future immunologists.

Autoimmunity Cancer Vaccines Cures

 

Latest News   

Milcah Scott is awarded a Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship

Milcah ScottCFI would like to congratulate Milcah Scott, a predoctoral student in the Masopust Lab. Milcah was awarded the Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship for her work on a suite of contemporary and complementary whole animal, cellular and molecular approaches to better define the transcriptional programs and phenotypes of stringently-identified, bona fide tissue resident memory CD8 T cells (TRM). Refined analyses of TRM will broaden our understanding of how TRM are generated and maintained in tissues and are key to addressing deficiencies in our understanding of how (TRM) effect pathogen protection, tumor control, and autoimmune pathogenesis. The purpose of the Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship award is to enable promising predoctoral students to obtain individualized, mentored research training from outstanding faculty sponsors while conducting dissertation research in scientific health-related fields to enhance the individual’s potential to develop into a productive, independent research scientist.

The Binstadt Lab in the University of Minnesota’s Center for Immunology seeks a new post-doctoral
fellow. This individual will work together with our team to explore mechanisms of cardiovascular
inflammation in the setting of systemic autoimmunity.

Applicants must hold a Ph.D. degree in biological science and have a recent track record of publication
of first-author peer-reviewed manuscripts.

● Preference will be given to applicants with Ph.D. degrees in Immunology (particularly
Autoimmunity) and/or expertise in Vascular Biology, particularly the role of inflammation in the
cardiovascular system.
● Experience working with small animal models, flow cytometry, immunofluorescent microscopy,
and analysis of transcriptomic data (e.g. scRNASeq) or similar large datasets is preferred.
● Preference will be given to applicants with demonstrated expertise in developing scientific
protocols, scientific writing, and outstanding letters of reference.

Please apply online using job code 340404. Also, email a curriculum vitae and a cover letter to Bryce
Binstadt, MD, Ph.D. Full job description here. 

 

Congrats JTJ.T. Greene, Ph.D. from the Freedman lab was awarded a postdoctoral fellowship from the American Cancer Society to support his ongoing research and training.  The Cancer Society awards researchers who are within 3 years of receiving a doctoral degree initial funding to start training for an independent career in cancer research. J.T. was also awarded The Ben G. Zimmerman Travel Award from the Department of Pharmacology, this award supports the participation (poster or oral presentation) of graduate students and postdoctoral trainees at scientific conferences.  

 

Mike Farrar and Brian Fife are funded to study antigen-specific T cells in diabetes

CFI professors' Michael Farrar, professor, and Virginia and David C. Utz Land Grant Chair in Fundamental Immunobiology, LMP and Brian Fife, associate professor of Medicine, recently received a five-year $590,000 grant from the National Institute of Allergy and Infectious Diseases (NIAID) for “Identifying and preventing antigen-specific T cells in diabetes.”

Marc Jenkins elected to the National Academy of Sciences and AAI awards him their highest honor: The Lifetime Achievement Award!

Marc NAS photo

CFI is honored to announce that our Director Marc Jenkins, PhD has been elected to the National Academy of Sciences. Marc's achievement is especially notable in that it has been over 50 years since a UMN Medical School faculty member has been added to this impressive organization of the country’s leading researchers. The National Academy of Sciences elects new members in recognition of their distinguished and continuing achievements in original research. Membership is a widely accepted mark of excellence in science and is considered one of the highest honors that a scientist can receive. Current NAS membership totals approximately 2,400 members and 500 foreign associates, of which approximately 190 have received Nobel prizes. Dr. Marc Jenkins has led a distinguished career whose scientific endeavors have answered critical questions in the field of immunology…. Marc is an exemplary scientist, educator, mentor, and advisor. To read more about Marc's accomplishments please click here.

AAI bestows their highest honor the Lifetime Achievement Award to Dr. Marc Jenkins

The American Association of Immunologists (AAI) has bestowed their highest honor on Dr. Marc Jenkins.  The 2020-21 Lifetime Achievement Award recognizes a deserving AAI member for a career of scientific achievement and for contributions to AAI and fellow immunologists and to the field of immunology.   For more information on all of Dr. Jenkins's achievements go here.  CFI would like to extend our congratulations and thank Dr. Jenkins for his guidance and leadership as well as the inspiration he inspires as a teacher, mentor, and scientist to those not only at our University but worldwide. The Virtual IMMUNOLOGY2021™ was held May 10–15, if you missed the awards presentation, click here

  • CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model

    The Stromnes lab was recently awarded an RO1 based on the work led by Dr. Adam Burrack. His recent first author  J. Immunol and Cell Report papers have identified a mechanistic basis for T cell exhaustion in pancreatic cancer and a feasible clinical strategy to overcome it.

  • Expansible residence decentralizes immune homeostasis

    While working on his doctoral thesis in the Masopust lab, Sathi Wijeyesinghe found that expansibility and tissue residency are generalizable qualities that underlie immune homeostasis, building on our initial exploration of resident memory T cell durability and maintenance, his "story" can be read in the March 2021 edition of Nature.

  • MHC class II tetramers engineered for enhanced binding to CD4 improve detection of antigen-specific T cells.

    In the May 2021 issue of Nature Biotechnology, a study led by Dr. T. Dileepan from the Jenkins group examined the effect of MHC class II tetramers engineered for enhanced binding, to improve the detection of low-affinity CD4 antigen-specific T cells go.nature.com/337Y6nY

  • T cell memory: Understanding COVID-19

    As the SARS-CoV-2 pandemic has progressed, increasing attention has focused on establishing natural and vaccine-induced immunity against this coronavirus and the disease, COVID-19, that it causes. In the 2021 preprint issue of Immunity, Jarjour, Masopust and Jameson explain the fundamental features of T cell memory and their potential relevance for effective immunity to SARS-CoV-2. Read here
  • Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression

    A study published in Nature Immunology which was led by Jesse Williams has formed new answers regarding atherosclerosis, the build-up of fats, cholesterol and other substances in and on the artery walls. Read here.

  • Thymic regulatory T cells arise via two distinct developmental programs

    The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self-antigens and non-self antigens remain unclear. Here the Farrar lab et al. found that mature Treg cells were generated through two distinct developmental programs involving CD25+ Treg cell progenitors and Foxp3lo Treg cell progenitors (Foxp3lo TregP cells). Read more 

Research ethics at the University of Minnesota

We are committed to protecting research participants, upholding ethical standards, and improving our practice at every step of our work.

Learn more about our commitment to research ethics 

Announcements


Tea and Talk!!

**In person returns: 1-101 MRF
9:00-10:00am|Zoom:here
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MICaB-Immunology Invited Speaker Seminar

Returns Fall 2021
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CFI Tea and Talk Time
Returns to In-Person 
2:00-2:30pm|Rooftop Terrace WMBB

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BGREAT and OPD Seminars:
Check calendar for all events

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Tues. Seminars: Aug. 3

9:00-10:00 a.m.|Zoom:here
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BGREAT and OPD Seminars:
Check calendar for all events
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Wed. Seminars: Aug. 4

All-Medical School COVID-19 Forum
Post forum questions can be submitted here|Register
Next Meeting: check here
9:15-10:00 a.m.| Zoom:here
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BGREAT and OPD Seminars:
Check calendar for all events

Global Gophers: Health and Wellness Webinar
8-9am|Register here
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Immunology Supergroup
Open

**In person returns: 1-125 CCRB
1:30-2:30 p.m.|Zoom:
here
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Thurs. Seminars: Aug. 5

MICaB Student Seminar Series
Check calendar for ZOOM info
Returns Fall 2021
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IBP/MD Center Seminar Series
Returns Fall 2021
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CFI Tea and Talk Time
2:00-2:30pm|Rooftop Terrace WMBB
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BGREAT and OPD Seminars 
Check calendar for all events

LSSURP Poster Symposium
9:30am – 11:30am|McNamara Alumni Center

Federal Resume Writing
1
pm – 2pm|Register here
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Friday Seminars: Aug. 6

BGREAT and OPD Seminars
Check calendar for events
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Save the date:

August 24, 2021

CFI/ReJUS Invited Postdoctoral Fellow seminar series

Mirna Perusina Lanfranca
Carter Immunology Center, University of Virginia

1:30-2:30pm|More info to follow
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Looking for a place to write?

If you are writing and need a quiet place to gather your thoughts, we have a spot for you.

See Annette Bethke, 2-142 WMBB to check out the office key.