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The Center for Immunology is an interdisciplinary research program at the University of Minnesota devoted to advancing the field of immunology and educating future immunologists.

Autoimmunity Cancer Vaccines Cures

 

Latest News
 

RED Seminar Series Returns!!

                           red Series 2020

 

Join REJUS and EWIS for our monthly discussions on race and gender inequality!!

Marc Jenkins recently announced the formation of Restorative Justice for the Underrepresented in Science (ReJUS) at the CFI. ReJUS was born in the wake of the murder of George Floyd, nationwide protests on racial discrimination and discriminatory policing practices including the use of deadly force against black persons. These events have shaken our world, and have been a very painful reminder of our collective silence and complicity in maintaining the status quo and allowing racial injustice to go unchallenged. While centuries of institutionalized racism is daunting to correct as individuals, as a collective of scientists, we can reassess our individual and institutional beliefs, practices, norms, and culture and set them on a more just and equitable course.

If you'd like to engage in further discussions on discrimination and racism in science or support the advancement of underrepresented minorities at the CFI, please consider participating in ReJUS. Natalie David and Jenna Johnson will be leading our December CFI discussion on racial and gender inequality. Natalie and Jenna have chosen to discuss topics surrounding how scientific racism has evolved and persisted, despite strong evidence that race is a social construct with no scientific basis.  They will be using the following materials: Superior: The Return of Race ScienceNPR Code Switch: Is 'Race Science' Making a Comeback?The Disturbing Resilience of Scientific Racism and How Can We Curb the Spread of Scientific Racism?

Meeting details:
Date: TBA
Duration: 1 hour and people are welcome to stay longer for further discussion
Join Zoom Meeting: here

23 UMN Faculty Named on 2020 Highly Cited Researchers List

CFI would like to congratulate the twenty-three current UMN researchers which are named in the 2020 Highly Cited Researchers list, published on 11/18/20 by insight and analytics firm Clarivate Analytics (@webofscience #HighlyCited2020). The international list recognizes researchers who published multiple highly cited papers during the last decade, and whose citation records place them in the top 1 percent of citation counts for field and publication year according to Clarivate’s Web of Science citation index. Of the 23 researchers, 6 are current CFI faculty. To read the full article here

 

Bryce Binstadt, MD is named director of Pediatric Rheumatology in the Department of Pediatrics

Bryce BinstadtCongratulations to Dr. Bryce Binstadt, he was recently named the director of the Pediatric Rheumatology division in the Department of Pediatrics. Pediatric Rheumatology is the specialty focused on the evaluation and care of children with arthritis and related diseases. Dr. Binstadt is a phsician-scientist who cares for children with arthritis, systemic lupus erythematosus, dermatomyositis, and related rheumatologic disorders and heads a laboratory in the Center for Immunology, focusing on understanding the pathogenesis of autoimmune diseases with particular emphasis on immune-mediated cardiovascular disease. Dr. Binstadt is also the Director of the Pediatric Rheumatology Fellowship Training Program, an Associate Director of the Medical Scientist Training Program (MD/PhD), and Director of the Pediatric Physician Scientist Training Program. He is routinely recognized as a Minnesota "Top Doctor" and a he is a distinguished University teaching professor in the University of Minnesota Medical School’s Department of Pediatrics. 

 

Dr. Yoji Shimizu has helped launch Faculty Fighting Racism, an initiative created as a first step to provide resources for understanding anti-racism and empowering faculty to take action. 

More center news.                         Meet our Faculty                              Join our Mail/Email lists

Marc NAS photo

CFI is honored to announce that our Director Marc Jenkins, PhD has been elected to the National Academy of Sciences. Marc's achievement is especially notable in that it has been over 50 years since a UMN Medical School faculty member has been added to this impressive organization of the country’s leading researchers. The National Academy of Sciences elects new members in recognition of their distinguished and continuing achievements in original research. Membership is a widely accepted mark of excellence in science and is considered one of the highest honors that a scientist can receive. Current NAS membership totals approximately 2,400 members and 500 foreign associates, of which approximately 190 have received Nobel prizes. Dr. Marc Jenkins has led a distinguished career whose scientific endeavors have answered critical questions in the field of immunology…. Marc is an exemplary scientist, educator, mentor, and advisor. To read more about Marc's accomplishments please click here. We are planning a virtual celebration to honor Dr. Jenkins. Please watch for more details on how to join our celebration, dates and time of the celebration will be listed here and on our Twitter account, @CFI_UMN.

  • Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression

    A study published in Nature Immunology which was led by Jesse Williams has formed new answers regarding atherosclerosis, the build-up of fats, cholesterol and other substances in and on the artery walls. Read here.

  • Naive B Cells with High-Avidity Germline-EncodedAntigen Receptors Produce Persistent IgM+andTransient IgG+Memory B Cells

    Immune memory often lasts for life, this is not the case for certain vaccines in some individuals. By studying B cell responses to phycoerythrin, in the June 2018 issue of Immunity, Pape et al. find that memory B cell responses can be shortlived when generated from precursors that experience unusually strong early signals of avid antigen binding via germline-encoded VH elements. Read more

  • Beura, Et Al, Nature Immunology paper 19,173-182 (2018)

    Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory

    Using two-photon intravital microscopy to visualize the responses of CD8resident memory T cells (Trm cells), Post Doctoral fellows in Masopust, Vezys, and Fife labs found that the Trm cells were highly motile but would pause and undergo in situ division after antigen challenge. Read more

  • Co-housing with pet store mice changes the immune system of laboratory mice

     Nature  highlights the work of Lalit Beura, Sara Hamilton, Marc Jenkins, Vaiva Vezys, Steve Jameson, Dave Masopust, et.al. and their evidence of how laboratory rodents can skew immunology research but that "dirty mice" can clean up the results. Read more

  • Thymic regulatory T cells arise via two distinct developmental programs

    The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self-antigens and non-self antigens remain unclear. Here the Farrar lab et al. found that mature Treg cells were generated through two distinct developmental programs involving CD25+ Treg cell progenitors and Foxp3lo Treg cell progenitors (Foxp3lo TregP cells). Read more 

  • Dual TCR T Cells: Identity Crisis or Multitaskers?

    In this study, Drs. Binstadt and Schuldt aim to provide a brief but comprehensive history of dual TCR T cell research, re-evaluate past observations in the context of current knowledge of the immune system, and identify key issues for future study. Read More

Research ethics at the University of Minnesota

We are committed to protecting research participants, upholding ethical standards, and improving our practice at every step of our work.

Learn more about our commitment to research ethics 

Announcements

Holiday-No Seminar

Holiday-No Seminar

Looking for a place to write?

If you are writing and need a quiet place to gather your thoughts, we have a spot for you.

See Annette Bethke, 2-142 WMBB to check out the office key.