The Center for Immunology is an interdisciplinary research program at the University of Minnesota devoted to advancing the field of immunology and educating future immunologists.
Autoimmunity • Cancer • Vaccines • Cures
Naive B Cells with High-Avidity Germline-EncodedAntigen Receptors Produce Persistent IgM+andTransient IgG+Memory B Cells
Immune memory often lasts for life, this is not the case for certain vaccines in some individuals. By studying B cell responses to phycoerythrin, in the June 2018 issue of Immunity, Pape et al. find that memory B cell responses can be shortlived when generated from precursors that experience unusually strong early signals of avid antigen binding via germline-encoded VH elements.
Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory
Using two-photon intravital microscopy to visualize the responses of CD8+ resident memory T cells (Trm cells), Post Doctoral fellows in Masopust, Vezys, and Fife labs found that the Trm cells were highly motile but would pause and undergo in situ division after antigen challenge. Read more
Co-housing with pet store mice changes the immune system of laboratory mice
Nature highlights the work of Lalit Beura, Sara Hamilton, Marc Jenkins, Vaiva Vezys, Steve Jameson, Dave Masopust, et.al. and their evidence of how laboratory rodents can skew immunology research but that "dirty mice" can clean up the results Read more
Thymic regulatory T cells arise via two distinct developmental programs
The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self-antigens and non-self antigens remain unclear. Here the Farrar lab et al. found that mature Treg cells were generated through two distinct developmental programs involving CD25+ Treg cell progenitors and Foxp3lo Treg cell progenitors (Foxp3lo TregP cells). Read more
Chrysalis: A New Method for High-Throughput Histo-Cytometry Analysis of Images and Movies
Advances in imaging have led to the development of powerful multispectral, quantitative imaging techniques, like histo-cytometry. The utility of this approach is limited, however, by the need for time-consuming manual image analysis. In an effort to address the time issue, Kotov and Pengo et al. created the software Chrysalis along with a suite of Imaris Xtensions to batch image processing and analysis to automate the processing workflow for confocal, epi-fluorescence, and two-photon microscopy images.
Dual TCR T Cells: Identity Crisis or Multitaskers?
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Save the Date!! and RSVP: The 2019 Dean's Distinguished Research Lectureship Honors Dr. David Masopust on Nov. 13, 2019
Fox 9 News highlights the work in the Masopust lab to develop a potential HIV vaccine
Dr. Borges da Silva awarded an NIH Pathway to Independence Award
CFI would like to congratulate Dr. Henrique Borges da Silva from the Jameson lab, he has been awarded a NIAID research grant to support his work. This fellowship aims to harness a strong cohort of new NIH-supported independent investigators. K99/R00 awardees receive support for independent projects and facilitate their transition to tenure-track or equivalent faculty positions. Henrique will work on the project: "Defining the function of extracellular ATP sensing for memory CD8+ T cell generation and longevity", and will seek to better understand how the "danger signal" eATP controls the long-term establishment of CD8 T cell memory.
Former UMN researcher Max D. Cooper, M.D. along with his colleague Jacques Miller, Ph.D. win the 2019 Albert Lasker Basic Medical Research Award
On September 10, 2019, Drs.Max Cooper Jacques MillerAlbert Lasker Basic Medical Research AwardLasker Awards 1963-1967fundamental discovery with Drs. Robert Good and Raymond PetersonNew England Journal of Medicine
CFI's Alex Khoruts is quoted by NBC News
On August 25, 2019, NBC news quoted Dr. Alex Khoruts in regards to the lack of guidelines for fecal microbiota transplants (FMTs). As the number of transplants increased so did the methods of delivery. Today the debate is whether or not to designate the FMT as an investigational drug or to continue with the FMTs as organ transplants. Here is the full NBC article, to read more about Dr. Khorut's own work with FMTs done by Steve LeBeau for the magazine Global Advances in Health and Medicine.
Drs. Vezys and Bhela awarded the 2019 Careers in Immunology Fellowship
Drs. Vaiva Vezys and Siddheshvar Bhela have been awarded an AAI Careers in Immunology Fellowship Program elopment of young scientists by providing eligible PIs with one year of salary support for a trainee in their lab. Postdoctoral trainee, Dr. Sid Bhela will receive salary support for his work on the regulatory function of tolerant CD8+ T cells. Congratulations to both Drs. Vezys and Bhela.
Dr. Ingunn Stromnes awarded the 2019 Julia Stagliano Pancreatic Cancer Action Network Catalyst Grant
Congratulations to Dr. Ingunn Stromnes. Dr. Stromnes was awarded the 2019 Julia Stagliano Pancreatic Cancer Action Network Catalyst Grant for her research project "Overcoming Immunotherapy Resistance in Pancreas Cancer". "I am incredibly honored to receive support from the Pancreatic Cancer Action Network for funding our research to develop safe and effective immunotherapies for pancreas cancer," said Stromnes. "My team is also enormously grateful for the generosity of Nancy Stagliano, who in memory of Julia Stagliano, supports pancreas cancer immunotherapy research." The Pancreatic Cancer Action Network (PanCAN)2019 research grants.
The Center for Immunology proudly hosted its first-ever Alumni Celebration
Research ethics at the University of Minnesota
U of MN Faculty
Become a Member
every Monday and Thursday
2:30 p.m. | 2-163 WMBB
Immunology Journal Club
Emily Truckenbrod-Jameson lab
9:00-10:00 a.m.| 2-115 CCRB
MICaB-Immunology Invited Speaker Seminar
Amit Sharma, Ph.D.
Department of Veterinary Biosciences, The Ohio State University, College of Medicine, Columbus, OH
“Viral and Host Determinants of SHIV Replication in Macaque Lymphocytes”
Cancer Center Seminar Series
Ingunn Stromnes, PhD
Assistant Professor of Microbiology and Immunology, University of Minnesota
"Overcoming immunotherapy resistance in pancreatic cancer."
9:00-10:00 a.m. | 1-125 CCRB
Infection and Immunity Research Conference
Next conference: Sept 26, 2019 **Note the date change
8:00-9:00 a.m.| A-420 Mayo
Robin Lee-Farrar Lab
“Nuclear corepressors NCOR1 and NCOR2 dynamically regulate proliferation and differentiation of developing and leukemic B cells”
12:00-1:00 p.m.| 1-110 LRB/MTRF
9:00-10:00 a.m.| 2-115 CCRB
MICaB-Immunology Invited Speaker Seminar
Stephen McSorley, Ph.D. *MICaB Alumni Invited Speaker*
Center for Comparative Medicine: Anatomy, Physiology and Cell Biology, University of California, Davis, CA
"CD4 T cell responses to bacterial infection"
Catherine Wu, MD, Professor, Medicine, Dana-Farber Cancer Institute, Harvard Medical School
"Driving T cells into tumors: a role for personal cancer vaccines"
9:00-10:00 a.m. | 1-125
Save the Date-November 13, 2019
Looking for a place to write?
If you are writing and need a quiet place to gather your thoughts, we have a spot for you.
See Annette Bethke, 2-142 WMBB to check out the office key.