The Center for Immunology is an interdisciplinary research program at the University of Minnesota devoted to advancing the field of immunology and educating future immunologists.
Autoimmunity • Cancer • Vaccines • Cures
Kris Hogquist is elected to the National Academy of Sciences
AIRE to host Postdoctoral Fellow Seminar Series
AIRE is excited to announce the next installment of the invited postdoctoral fellow seminar series. The seminar series is an effort to pique the interest of outstanding postdoctoral fellows from underrepresented minority backgrounds as they begin their faculty searches in CFI and to provide an opportunity to network with the CFI community. The invited postdoctoral fellows have the opportunity to present their research at a seminar via Zoom and to meet with up to three CFI faculty members. AIRE and CFI believe that having a diverse group of scientists and trainees in an inclusive environment is essential for scientific excellence. Any questions can be directed to email@example.com
CFI and AIRE are excited to welcome Juan Camilo Sanchez-Arcila, as our next speaker for the Postdoctoral Seminar Series,
Please join us on June 14, 2022, from 1:30-2:30 p.m., join us over zoom using the following link here.
Dr. Sanchez-Arcila is currently a postdoctoral fellow in the lab of Dr. Kirk Jensen at the University of California Merced. His research is focused on studying the genetic basis of murine immune responses to Toxoplasma gondii, the etiologic agent of toxoplasmosis. He is utilizing forward genetic screens to determine key genes involved in regulating protective immunity against T. gondii with a focus on adaptive immune responses involving memory CD8+ T cells.
Congratulations to Dr. Harry Orr, 2022 recipient of the Kavli Prize in Neuroscience
The Kavli Foundation and the Norwegian Ministry of Education and Research announced June 1, 2022 that LMP professor Harry Orr is one of four winners of the 2022 Kavli Prize in Neuroscience. Named after Fred Kavli, a Norwegian-American physicist, entrepreneur and philanthropist, the biennial Kavli Prize “honors scientists for breakthroughs in astrophysics, nanoscience and neuroscience – transforming our understanding of the big, the small and the complex.” Orr was honored for his pioneering genetic research on the neurodegenerative disease spinocerebellar ataxia type 1 (SCA1), a collaborative effort with Baylor College of Medicine’s Huda Zogbhi, also a 2022 Kavli Prize winner. He will travel to Norway to receive the prize from Haakon, Crown Prince of Norway, in September. Each Kavli Prize consists of a gold medal, a scroll, and a cash award of $1 million, which is shared among the winners in each category. Congratulations Harry! Read more here.
Spring has been a busy time for CFI members:
Dr. Jesse Williams was awarded an NIH R01 grant "Sex and stress hormones control adrenal gland macrophage development and function" and a MN Department of Health grant to study monocyte trafficking following traumatic brain injury.
Dr. Matouš Vobořil, a postdoctoral fellow in the Hogquist lab, has been awarded a CRI Irvington Postdoctoral Fellowship.
Natalie David, MSTP/MICaB graduate student in the Farrar Lab was awarded the 2022 President’s Student Leadership & Service Award (PSLSA), this award recognizes the accomplishments and contributions of outstanding student leaders for their service to the University of Minnesota Twin Cities and the surrounding community.
Monica Sauer, BMBB graduate student in the Freedman Lab has been awarded the 2022 Armstrong-Pothapragada Graduate Fellowship by the Department and Graduate Program in Biochemistry, Molecular Biology & Biophysics. "This fellowship is given to a talented student who is in good standing and shows potential in their chosen field."
Dr. Ingunn Stromnes, received an R01 from National Cancer Institute entitled, "Enhancing engineered T cell therapeutic efficacy for the treatment of pancreatic ductal adenocarcinoma". (Co-Investigators are Drs. Stephen Shen, Xavier Revelo, Beau Webber). She also received one of the first Idea Awards from the Department of Defense for pancreatic cancer research entitled : “Manipulating Myeloid Cells to Promote Immunotherapy Efficacy of Pancreatic Ductal Adenocarcinoma" (Co-Investigators are Drs. Jesse Williams and Kaylee Schwertfeger)
Dr. Nicholas Maurice, a postdoc inStephen Jameson’s lab, was awarded a one-year grant from the National Cancer Institute (NCI) to study his proposal “Profiling and leveraging bystander T cells within the tumor microenvironment.”
Congratulations to everyone!!
CFI debuts new “CFI Legends Wall”
Recently a new wall of recognition was added to the Center for Immunology. To commemorate over 25 years of outstanding research, CFI is honoring two of the founding members of the Center for Immunology, Drs. Tucker LeBien and Matthew Mescher. Dr. LeBien was instrumental in revitalizing immunology as a discipline at the University of Minnesota. After the hiring of a prominent immunologist, Dr. Matthew Mescher in 1993, both LeBien and Mescher worked together to organize all of the UMN immunologists from several departments throughout the medical school. Once organized the group of 11 other faculty members formed a new graduate program to enhance the visibility of training opportunities in immunology. Mescher then applied for grants to establish contiguous research space and in 1995 the official Center for Immunology was launched. Mescher was named the first CFI director and continued to lead the center until 2013 when he stepped down. LeBien continued to support the CFI at an administrative level as the Vice Dean for Research in the Medical School and Associate Vice President for Research in the Academic Health Center until his retirement in January 2022. CFI is thrilled to begin the wall with two strong leaders. Stop by the 2nd floor WMBB to see the beautiful tributes to each of the legends.
CFI welcomes our newest faculty member, Monica Campo Patiño, MD, MPH
The Center for Immunology is thrilled to welcome Monica Campo Patiño, MD, MPH to the University of Minnesota and to our group housed in WMBB. Dr. Campo Patiño completed medical school at Universidad El Bosque in Bogotá, Colombia and a Master’s in Public Health at the Harvard T.H. Chan School of Public Health, and subsequently completed an internal medicine residency at Tufts Medical Center in Boston. Dr. Campo Patiño has completed a research fellowship with Dr. Patricia Finn on the interaction of innate and adaptive immune response in asthma. She then moved to Seattle and did a fellowship in pulmonary and critical care medicine at the University of Washington and her postdoctoral training was completed with Dr. Thomas Hawn, University of Washington studying genetic susceptibility and innate immunity to tuberculosis.
At the University of Minnesota, Dr. Campo Patiño will focus on examining regulatory innate immunity pathways of the early stages of tuberculosis, which can lead to the discovery of new therapies. She is currently looking for new hires, new collaborations, and comradery! Pass by her office at WMBB 2-112 to say Hi! For more info, click here.
CFI wishes Dr. Tucker LeBien a happy retirement
After more than 40 years at the University of Minnesota (UMN), Dr. Tucker LeBien is retiring. Dr. LeBien devoted his 30-year research career to the study of B cells and leukemia. During this time, he played a pivotal role in the formation of the Center for Immunology (CFI), and the Microbiology, Immunology, and Cancer Biology (MICaB) graduate program. For the last 10 years, he was the Vice Dean for Research in the Medical School and Associate Vice President for Research in the Academic Health Center, where The UMN Cancer Center and Medical Scientist Training program benefited from his service as a leader and director. Most recently, LeBien was the Senior Advisor for Research Operations in the Office of Academic Clinical Affairs and Director of the Office of Discovery and Translation (ODAT) in the University's Clinical and Translational Science Institute (CTSI). Dr. LeBien recently sat down with LMP's Bill Hoffman to reflect on his time at UMN, read the interview here. For a more indepth interview, revisit his 2019 “Legends in Pathology” video interview here. We would like to wish Dr. LeBien a relaxing and wonderful retirement but most importantly we will remember Dr. LeBien as a leader, mentor, and a friend to many of his colleagues who will continue his legacy
Join AIRE and EWIS for our monthly discussions on race and gender inequality!!
Securing your Zoom meeting
Marc Jenkins inducted into the National Academy of Sciences
On Friday, April 29, 2022, members elected from 2019 to 2021 were inducted into the National Academy of Sciences. Follow for coverage of the NAS members’ distinguished and continuing achievements in original research. You can also watch the presentations here: http://ow.ly/Qia550ITL2F
Director Marc Jenkins, PhD was elected to the National Academy of Sciences in 2020
CFI was also honored to partner with the Department of Microbiology & Immunology and the UMN Medical School to celebrate Marc's achievements on April 21, 2022. In addition to his election into the National Academy of Sciences, Marc was also awarded the American Association of Immunologists Lifetime Achievement Award. The AAI Lifetime Achievement Award is the highest honor bestowed by the AAI Council upon an AAI member. This award recognizes a deserving member for a career of scientific achievement and for contributions to AAI and fellow immunologists. A reception was held to honor Marc and his accomplishments, Drs. Jakub Tolar, Ashley Haase, and Kristin Hogquist all spoke on Marc's behalf and then the audience was entertained by music and vocals from 2 of Marc's peers, Drs. Gary Dunny and Daniel Mueller.
Enhanced CD4+ and CD8+ T cell infiltrate within convex hull defined pancreatic islet borders as autoimmune diabetes progresses
Nature's Scientific Reports, August 25, 2021 issue has an article by Alex Dwyer in the Fife lab on a new process to identify islet damage where he introduces an automated convex hull-based analytical procedure using a macro written in FIJI for inflammation. This new tool could elevate inflammation for diabetes assessment and inflammation in general. Read more here: https://z.umn.edu/72ty
CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model
The Stromnes lab was recently awarded an RO1 based on the work led by Dr. Adam Burrack. His recent first author J. Immunol and Cell Report papers have identified a mechanistic basis for T cell exhaustion in pancreatic cancer and a feasible clinical strategy to overcome it.
Expansible residence decentralizes immune homeostasis
While working on his doctoral thesis in the Masopust lab, Sathi Wijeyesinghe found that expansibility and tissue residency are generalizable qualities that underlie immune homeostasis, building on our initial exploration of resident memory T cell durability and maintenance, his "story" can be read in the March 2021 edition of Nature.
MHC class II tetramers engineered for enhanced binding to CD4 improve detection of antigen-specific T cells.
T cell memory: Understanding COVID-19As the SARS-CoV-2 pandemic has progressed, increasing attention has focused on establishing natural and vaccine-induced immunity against this coronavirus and the disease, COVID-19, that it causes. In the 2021 preprint issue of Immunity, Jarjour, Masopust and Jameson explain the fundamental features of T cell memory and their potential relevance for effective immunity to SARS-CoV-2. Read here
Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression
A study published in Nature Immunology which was led by Jesse Williams has formed new answers regarding atherosclerosis, the build-up of fats, cholesterol and other substances in and on the artery walls. Read here.
Research ethics at the University of Minnesota
Mondays and Thursdays
2:00-2:30pm| 2-163 WMBB
COVID-19 Scientific Daily Update________________________
Mon. Seminars: June 27
12pm – 1pm|
Lillehei Heart Institute Lecture Series
This lecture is webcast via Zoom-no live meeting.
Returns Fall 2022
Thurs. Seminars: June 30
Creating and Presenting Virtual Posters
Fri. Seminars: July 1
AAMC Early Career Seminar for Women Faculty (Jul. 19-22, Mpls)
This seminar is designed for women physicians and scientists with a minimum of two years of experience as an assistant professor and provides foundational leadership knowledge and skills to achieve career goals and thrive as a successful leader in academic medicine and science. OFA provides limited funding to cover registration fees for 2 attendees. Faculty should email firstname.lastname@example.org submitting their application to confirm the availability of funding.
Check out the Path to Publication workshop
June 15, 2022. More information and registration are here.