Publications

The Center for Immunology produces an immense amount of research each year.  The data produced is comprehensive and timely to research across the globe.  Our research is supported by Government, Commercial and Industrial grants and private funds and is produced in our state of the art research facilities.  The research is carried out by faculty members, visiting scholars, post-doctoral fellows, graduate, and undergraduate students and technicians. The Center for Immunology also has a strong collaboration history with colleagues at other Universities and research companies worldwide.

                                              

 To honor the Center for Immunology faculty with 200 or more citations on one paper we have created our wall of honor. 

 

View the Wall of Honor

 

2022 Publications

Functional virus-specific memory T cells survey glioblastoma. 
Ning J, Gavil NV, Wu S, Wijeyesinghe S, Weyu E, Ma J, Li M, Grigore FN, Dhawan S, Skorput AGJ, Musial SC, Chen CC, Masopust D, Rosato PC. 
Cancer Immunol Immunother. 2022 Aug;71(8):1863-1875. doi: 10.1007/s00262-021-03125-w. Epub 2022 Jan 10.
PMID: 35001153

Natural Killer Cell Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity Against Plasmodium falciparum-Infected Red Blood Cells.
Dick JK, Hart GT.
Methods Mol Biol. 2022;2470:641-657. doi: 10.1007/978-1-0716-2189-9_48.
PMID: 35881380

Type 2 cytokines in the thymus activate Sirpα+ dendritic cells to promote clonal deletion.
Breed ER, Vobořil M, Ashby KM, Martinez RJ, Qian L, Wang H, Salgado OC, O'Connor CH, Hogquist KA.
Nat Immunol. 2022 Jul;23(7):1042-1051. doi: 10.1038/s41590-022-01218-x. Epub 2022 May 30.
PMID: 35637352

Targeted sequencing of candidate gene regions for myelofibrosis in dogs.
Campbell AG, Seelig DM, Beckman JD, Minor KM, Heinrich DA, Friedenberg SG, Modiano JF, Furrow E.
J Vet Intern Med. 2022 Jul;36(4):1237-1247. doi: 10.1111/jvim.16476. Epub 2022 Jul 11.
PMID: 35815881

Immune tolerance of food is mediated by layers of CD4+ T cell dysfunction.
Hong SW, Krueger PD, Osum KC, Dileepan T, Herman A, Mueller DL, Jenkins MK.
Nature. 2022 Jul;607(7920):762-768. doi: 10.1038/s41586-022-04916-6. Epub 2022 Jul 6.
PMID: 35794484

Retinoic acid signaling acts as a rheostat to balance Treg function.
Thangavelu G, Andrejeva G, Bolivar-Wagers S, Jin S, Zaiken MC, Loschi M, Aguilar EG, Furlan SN, Brown CC, Lee YC, Hyman CM, Feser CJ, Panoskaltsis-Mortari A, Hippen KL, MacDonald KP, Murphy WJ, Maillard I, Hill GR, Munn DH, Zeiser R, Kean LS, Rathmell JC, Chi H, Noelle RJ, Blazar BR.
Cell Mol Immunol. 2022 Jul;19(7):820-833. doi: 10.1038/s41423-022-00869-y. Epub 2022 May 17.
PMID: 35581350

Combining nilotinib and PD-L1 blockade reverses CD4+ T-cell dysfunction and prevents relapse in acute B-cell leukemia.
Tracy SI, Venkatesh H, Hekim C, Heltemes-Harris LM, Knutson TP, Bachanova V, Farrar MA.
Blood. 2022 Jul 28;140(4):335-348. doi: 10.1182/blood.2021015341.
PMID: 35275990

An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism.
Zhang Z, Salgado OC, Liu B, Moazzami Z, Hogquist KA, Farrar MA, Ruan HB.
Front Immunol. 2022 Jul 8;13:874863. doi: 10.3389/fimmu.2022.874863. eCollection 2022.
PMID: 35874700 

P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy.
Wanhainen KM, Peng C, Zhou MH, Macedo BG, O'Flanagan S, Yang T, Kelekar A, Burbach BJ, Borges da Silva H, Jameson SC.
Cancer Immunol Res. 2022 Jul 1;10(7):871-884. doi: 10.1158/2326-6066.CIR-21-0691.
PMID: 35588154

Boosting corrects a memory B cell defect in SARS-CoV-2 mRNA-vaccinated patients with inflammatory bowel disease.
Pape KA, Dileepan T, Matchett WE, Ellwood C, Stresemann S, Kabage AJ, Kozysa D, Evert C, Matson M, Lopez S, Krueger PD, Graiziger CT, Vaughn BP, Shmidt E, Rhein J, Schacker TW, Bold TD, Langlois RA, Khoruts A, Jenkins MK.
JCI Insight. 2022 Jun 22;7(12):e159618. doi: 10.1172/jci.insight.159618.
PMID: 35730567

Single-cell characterization of step-wise acquisition of carboplatin resistance in ovarian cancer.
Wenzel AT, Champa D, Venkatesh H, Sun S, Tsai CY, Mesirov JP, Bui JD, Howell SB, Harismendy O.
NPJ Syst Biol Appl. 2022 Jun 17;8(1):20. doi: 10.1038/s41540-022-00230-z.
PMID: 35715421

CD47 Promotes Autoimmune Valvular Carditis by Impairing Macrophage Efferocytosis and Enhancing Cytokine Production.
Meier LA, Faragher JL, Osinski V, Auger JL, Voeller R, Marath A, Binstadt BA.
J Immunol. 2022 Jun 15;208(12):2643-2651. doi: 10.4049/jimmunol.2100903. Epub 2022 Jun 3.
PMID: 35867674

Unravelling the sex-specific diversity and functions of adrenal gland macrophages.
Dolfi B, Gallerand A, Firulyova MM, Xu Y, Merlin J, Dumont A, Castiglione A, Vaillant N, Quemener S, Gerke H, Stunault MI, Schrank PR, Kim SH, Zhu A, Ding J, Gilleron J, Magnone V, Barbry P, Dombrowicz D, Duranton C, Wakkach A, Blin-Wakkach C, Becher B, Pagnotta S, Argüello RJ, Rantakari P, Chakarov S, Ginhoux F, Zaitsev K, Kim KW, Yvan-Charvet L, Guinamard RR, Williams JW, Ivanov S.
Cell Rep. 2022 Jun 14;39(11):110949. doi: 10.1016/j.celrep.2022.110949.
PMID: 35705045

Macrophage Fate Mapping.
Xu Y, Schrank PR, Williams JW.
Curr Protoc. 2022 Jun;2(6):e456. doi: 10.1002/cpz1.456.
PMID: 35687806

Differential hydrogen sulfide production by a human cohort in response to animal- and plant-based diet interventions.
Teigen L, Mathai PP, Lopez S, Matson M, Elkin B, Kozysa D, Kabage AJ, Hamilton M, Vaughn BP, Sadowsky MJ, Khoruts A.
Clin Nutr. 2022 Jun;41(6):1153-1162. doi: 10.1016/j.clnu.2022.03.028. Epub 2022 Apr 5.
PMID: 35500315

Embracing the heterogeneity of natural viruses in mouse studies.
Fiege JK, Langlois RA.
J Gen Virol. 2022 Jun;103(6). doi: 10.1099/jgv.0.001758.PMID: 35737518

Parabiosis in Mice to Study Tissue Residency of Immune Cells.
Wang H, Gavil NV, Koewler N, Masopust D, Jameson SC.
Curr Protoc. 2022 May;2(5):e446. doi: 10.1002/cpz1.446.
PMID: 35612420

Respiratory Influenza Virus Infection Causes Dynamic Tuft Cell and Innate Lymphoid Cell Changes in the Small Intestine. 
Roach SN, Fiege JK, Shepherd FK, Wiggen TD, Hunter RC, Langlois RA.
J Virol. 2022 May 11;96(9):e0035222. doi: 10.1128/jvi.00352-22. Epub 2022 Apr 21
PMID: 35446142

Preclinical Efficacy and Selectivity of Vaccines Targeting Fentanyl, Alfentanil, Sufentanil, and Acetylfentanyl in Rats.
Baehr C, Robinson C, Kassick A, Jahan R, Gradinati V, Averick SE, Runyon SP, Pravetoni M.
ACS Omega. 2022 May 4;7(19):16584-16592. doi: 10.1021/acsomega.2c00820. eCollection 2022 May 17.
PMID: 35601290

Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma.
Mills LJ, Scott MC, Shah P, Cunanan AR, Deshpande A, Auch B, Curtin B, Beckman KB, Spector LG, Sarver AL, Subramanian S, Richmond TA, Modiano JF.
Bone. 2022 May;158:115716. doi: 10.1016/j.bone.2020.115716. Epub 2020 Oct 27.
PMID: 33127576

γδ Thymocyte Maturation and Emigration in Adult Mice.
Joannou K, Golec DP, Wang H, Henao-Caviedes LM, May JF, Kelly RG, Chan R, Jameson SC, Baldwin TA.
J Immunol. 2022 May 1;208(9):2131-2140. doi: 10.4049/jimmunol.2100360. Epub 2022 Apr 8.
PMID: 35396221

Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome.
Edwinson AL, Yang L, Peters S, Hanning N, Jeraldo P, Jagtap P, Simpson JB, Yang TY, Kumar P, Mehta S, Nair A, Breen-Lyles M, Chikkamenahalli L, Graham RP, De Winter B, Patel R, Dasari S, Kashyap P, Griffin T, Chen J, Farrugia G, Redinbo MR, Grover M.
Nat Microbiol. 2022 May;7(5):680-694. doi: 10.1038/s41564-022-01103-1. Epub 2022 Apr 28.
PMID: 35484230

Respiratory Influenza Virus Infection Causes Dynamic Tuft Cell and Innate Lymphoid Cell Changes in the Small Intestine.
Roach SN, Fiege JK, Shepherd FK, Wiggen TD, Hunter RC, Langlois RA.
J Virol. 2022 May 11;96(9):e0035222. doi: 10.1128/jvi.00352-22. Epub 2022 Apr 21.
PMID: 35446142

Pharmacological Profiling of Antifentanyl Monoclonal Antibodies in Combination with Naloxone in Pre- and Postexposure Models of Fentanyl Toxicity.
Baehr CA, Wu MM, Pandit SG, Arias-Umana J, AuCoin D, Pravetoni M.
J Pharmacol Exp Ther. 2022 May;381(2):129-136. doi: 10.1124/jpet.121.001048. Epub 2022 Feb 13.
PMID: 35153198

A dominant function of LynB kinase in preventing autoimmunity. 
Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. 
Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. 
PMID: 35452291

Efficacy and Selectivity of Monovalent and Bivalent Vaccination Strategies to Protect against Exposure to Carfentanil, Fentanyl, and Their Mixtures in Rats.
Crouse B, Wu MM, Gradinati V, Kassick AJ, Song D, Jahan R, Averick S, Runyon S, Comer SD, Pravetoni M.
ACS Pharmacol Transl Sci. 2022 Apr 20;5(5):331-343. doi: 10.1021/acsptsci.1c00260. eCollection 2022 May 13.
PMID: 35592436

Brown adipose tissue involution associated with progressive restriction in progenitor competence.
Huang Z, Zhang Z, Moazzami Z, Heck R, Hu P, Nanda H, Ren K, Sun Z, Bartolomucci A, Gao Y, Chung D, Zhu W, Shen S, Ruan HB.
Cell Rep. 2022 Apr 12;39(2):110575. doi: 10.1016/j.celrep.2022.110575.
PMID: 35417710

The Conundrum of Lung Disease and Drug Hypersensitivity-like Reactions in Systemic Juvenile Idiopathic Arthritis.
Binstadt BA, Nigrovic PA.
Arthritis Rheumatol. 2022 Apr 12. doi: 10.1002/art.42137. Online ahead of print.
PMID: 35413159

Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C.
Zhao M, Ren K, Xiong X, Xin Y, Zou Y, Maynard JC, Kim A, Battist AP, Koneripalli N, Wang Y, Chen Q, Xin R, Yang C, Huang R, Yu J, Huang Z, Zhang Z, Wang H, Wang D, Xiao Y, Salgado OC, Jarjour NN, Hogquist KA, Revelo XS, Burlingame AL, Gao X, von Moltke J, Lin Z, Ruan HB.
Immunity. 2022 Apr 12;55(4):623-638.e5. doi: 10.1016/j.immuni.2022.03.009. Epub 2022 Apr 5.PMID: 35385697

Distinct myeloid antigen-presenting cells dictate differential fates of tumor-specific CD8+ T cells in pancreatic cancer.
Burrack AL, Schmiechen ZC, Patterson MT, Miller EA, Spartz EJ, Rollins MR, Raynor JF, Mitchell JS, Kaisho T, Fife BT, Stromnes IM. 
JCI Insight. 2022 Apr 8;7(7):e151593. doi: 10.1172/jci.insight.151593. 
PMID: 35393950

SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding.
Brian BF 4th, Sjaastad FV, Freedman TS.
Sci Rep. 2022 Apr 7;12(1):5875. doi: 10.1038/s41598-022-09589-9. 
PMID: 35393453

Differential hydrogen sulfide production by a human cohort in response to animal- and plant-based diet interventions.
Teigen L, Mathai PP, Lopez S, Matson M, Elkin B, Kozysa D, Kabage AJ, Hamilton M, Vaughn BP, Sadowsky MJ, Khoruts A.
Clin Nutr. 2022 Apr 5;41(6):1153-1162. doi: 10.1016/j.clnu.2022.03.028. Online ahead of print.
PMID: 35500315

The Extracellular ATP Receptor P2RX7 Imprints a Promemory Transcriptional Signature in Effector CD8⁺ T Cells. 
Vardam-Kaur T, van Dijk S, Peng C, Wanhainen KM, Jameson SC, Borges da Silva H.
J Immunol. 2022 Apr 1;208(7):1686-1699. doi: 10.4049/jimmunol.2100555. Epub 2022 Mar 9.
PMID: 35264459

The B-side of B cells in NAFLD.
Barrow F, Revelo XS.
Hepatology. 2022 Mar 27. doi: 10.1002/hep.32481. Online ahead of print.
PMID: 35340064

Glucosamine facilitates cardiac ischemic recovery via recruiting Ly6C^low monocytes in a STAT1 and O-GlcNAcylation-dependent fashion.
Zhou W, Jiang X, Tang Q, Ding L, Xiao W, Li J, Wu Y, Ruan HB, Shen Z, Chen W.
Clin Transl Med. 2022 Mar;12(3):e762. doi: 10.1002/ctm2.762.
PMID: 35343077

Toll-like Receptor 7 and 8 Imidazoquinoline-Based Agonist/Antagonist Pairs.
Yang M, Larson PG, Brown L, Schultz JR, Kucaba TA, Griffith TS, Ferguson DM.
Bioorg Med Chem Lett. 2022 Mar 1;59:128548. doi: 10.1016/j.bmcl.2022.128548. Epub 2022 Jan 18.
PMID: 35051578

Examination of IgG Fc Receptor CD16A and CD64 Expression by Canine Leukocytes and Their ADCC Activity in Engineered NK Cells.
Hullsiek R, Li Y, Snyder KM, Wang S, Di D, Borgatti A, Lee C, Moore PF, Zhu C, Fattori C, Modiano JF, Wu J, Walcheck B.
Front Immunol. 2022 Feb 24;13:841859. doi: 10.3389/fimmu.2022.841859. eCollection 2022.
PMID: 35281028

Correction to: Functional virus‑specific memory T cells survey glioblastoma.
Ning J, Gavil NV, Wu S, Wijeyesinghe S, Weyu E, Ma J, Li M, Grigore FN, Dhawan S, Skorput AGJ, Musial SC, Chen CC, Masopust D, Rosato PC.
Cancer Immunol Immunother. 2022 Feb 18. doi: 10.1007/s00262-022-03168-7. Online ahead of print.
PMID: 35179625

Redox regulation of age-associated defects in generation and maintenance of T cell self-tolerance and immunity to foreign antigens.
Hester AK, Semwal MK, Cepeda S, Xiao Y, Rueda M, Wimberly K, Venables T, Dileepan T, Kraig E, Griffith AV.
Cell Rep. 2022 Feb 15;38(7):110363. doi: 10.1016/j.celrep.2022.110363.
PMID: 35172147

Insufficiency of compound immune checkpoint blockade to overcome engineered T cell exhaustion in pancreatic cancer.
Stromnes IM, Hulbert A, Rollins MR, Basom RS, Delrow J, Bonson P, Burrack AL, Hingorani SR, Greenberg PD. 
J Immunother Cancer. 2022 Feb;10(2):e003525. doi: 10.1136/jitc-2021-003525.
PMID: 35210305

Characterization of influenza A virus induced transposons reveals a subgroup of transposons likely possessing the regulatory role as eRNAs.
Shen SS, Nanda H, Aliferis C, Langlois RA.
Sci Rep. 2022 Feb 9;12(1):2188. doi: 10.1038/s41598-022-06196-6.
PMID: 35140280

Natural rodent model of viral transmission reveals biological features of virus population dynamics.
Fay EJ, Balla KM, Roach SN, Shepherd FK, Putri DS, Wiggen TD, Goldstein SA, Pierson MJ, Ferris MT, Thefaine CE, Tucker A, Salnikov M, Cortez V, Compton SR, Kotenko SV, Hunter RC, Masopust D, Elde NC, Langlois RA.
J Exp Med. 2022 Feb 7;219(2):e20211220. doi: 10.1084/jem.20211220. Epub 2021 Dec 27. 
PMID: 34958350

Lung-resident memory B cells established after pulmonary influenza infection display distinct transcriptional and phenotypic profiles.
Tan HX, Juno JA, Esterbauer R, Kelly HG, Wragg KM, Konstandopoulos P, Alcantara S, Alvarado C, Jones R, Starkey G, Wang BZ, Yoshino O, Tiang T, Grayson ML, Opdam H, D'Costa R, Vago A; Austin Liver Transplant Perfusionist Group, Mackay LK, Gordon CL, Masopust D, Groom JR, Kent SJ, Wheatley AK.
Sci Immunol. 2022 Jan 28;7(67):eabf5314. doi: 10.1126/sciimmunol.abf5314. Epub 2022 Jan 28.
PMID: 35089815

Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8⁺ tissue-resident memory T cells.
Peng C, Huggins MA, Wanhainen KM, Knutson TP, Lu H, Georgiev H, Mittelsteadt KL, Jarjour NN, Wang H, Hogquist KA, Campbell DJ, Borges da Silva H, Jameson SC.
Immunity. 2022 Jan 11;55(1):98-114.e5. doi: 10.1016/j.immuni.2021.11.017. Epub 2021 Dec 20.
PMID: 34932944

Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes.
Evrard M, Wynne-Jones E, Peng C, Kato Y, Christo SN, Fonseca R, Park SL, Burn TN, Osman M, Devi S, Chun J, Mueller SN, Kannourakis G, Berzins SP, Pellicci DG, Heath WR, Jameson SC, Mackay LK.
J Exp Med. 2022 Jan 3;219(1):e20210116. doi: 10.1084/jem.20210116. Epub 2021 Oct 22.
PMID: 34677611

 

2021 publications

2020 publications

2019 publications

2018 publications

2017 publications