Publications
The Center for Immunology produces an immense amount of research each year. The data produced is comprehensive and timely to research across the globe. Our research is supported by Government, Commercial and Industrial grants and private funds and is produced in our state of the art research facilities. The research is carried out by faculty members, visiting scholars, post-doctoral fellows, graduate, and undergraduate students and technicians. The Center for Immunology also has a strong collaboration history with colleagues at other Universities and research companies worldwide.
To honor Center for Immunology faculty with 200 or more citations on one paper we have created our wall of honor.
2018 publications
US Immigration Westernizes the Human Gut Microbiome.
Vangay P, Johnson AJ, Ward TL, Al-Ghalith GA, Shields-Cutler RR, Hillmann BM, Lucas SK, Beura LK, Thompson EA, Till LM, Batres R, Paw B, Pergament SL, Saenyakul P, Xiong M, Kim AD, Kim G, Masopust D, Martens EC, Angkurawaranon C, McGready R, Kashyap PC, Culhane-Pera KA, Knights D.
Cell. 2018 Nov 1;175(4):962-972.e10. doi: 10.1016/j.cell.2018.10.029.
PMID: 30388453
Targeting the microbiome: from probiotics to fecal microbiota transplantation.
Khoruts A.
Genome Med. 2018 Oct 30;10(1):80. doi: 10.1186/s13073-018-0592-8.
PMID: 30376869
Enrichment and Quantification of Epitope-specific CD4+ T Lymphocytes using Ferromagnetic Iron-gold and Nickel Nanowires.
Shore DE, Dileepan T, Modiano JF, Jenkins MK, Stadler BJH.
Sci Rep. 2018 Oct 24;8(1):15696. doi: 10.1038/s41598-018-33910-0.
PMID: 30356071
Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma.
Rahrmann EP, Wolf NK, Otto GM, Heltemes Harris L, Ramsey LB, Shu J, LaRue RS, Linden MA, Rathe SK, Starr TK, Farrar MA, Moriarity BS, Largaespada DA.
Mol Cancer Res. 2018 Oct 24. pii: molcanres.0582.2018. doi: 10.1158/1541-7786.MCR-18-0582. [Epub ahead of print]
PMID: 30355676
The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease.
McDonald-Hyman C, Muller JT, Loschi M, Thangavelu G, Saha A, Kumari S, Reichenbach DK, Smith MJ, Zhang G, Koehn BH, Lin J, Mitchell JS, Fife BT, Panoskaltsis-Mortari A, Feser CJ, Kirchmeier AK, Osborn MJ, Hippen KL, Kelekar A, Serody JS, Turka LA, Munn DH, Chi H, Neubert TA, Dustin ML, Blazar BR.
J Clin Invest. 2018 Oct 1;128(10):4604-4621. doi: 10.1172/JCI95713. Epub 2018 Aug 14.
PMID: 30106752
Embracing microbial exposure in mouse research.
Huggins MA, Jameson SC, Hamilton SE.
J Leukoc Biol. 2018 Sep 27. doi: 10.1002/JLB.4RI0718-273R. [Epub ahead of print] Review.
PMID:30260516
1,25-Dihydroxyvitamin D3 increases the methionine cycle, CD4+ T cell DNA methylation and Helios+Foxp3+ T regulatory cells to reverse autoimmune neurodegenerative disease.
Moore JR, Hubler SL, Nelson CD, Nashold FE, Spanier JA, Hayes CE.
J Neuroimmunol. 2018 Sep 21;324:100-114. doi: 10.1016/j.jneuroim.2018.09.008. [Epub ahead of print]
PMID:30267995
Is a Human CD8 T-Cell Vaccine Possible, and if So, What Would It Take? CD8 T-Cell Vaccines: To B or Not to B?
Beura LK, Jameson SC, Masopust D.
Cold Spring Harb Perspect Biol. 2018 Sep 4;10(9). pii: a028910. doi: 10.1101/cshperspect.a028910. Review.
PMID: 29254982
Human plasma cell derived monoclonal antibodies to post-translationally modified proteins recognize amino acid motifs rather than specific proteins.
Steen J, Forsström B, Sahlström P, Odowd V, Israelsson L, Krishnamurthy A, Badreh S, Mathsson Alm L, Compson J, Ramsköld D, Ndlovu W, Rapecki S, Hansson M, Titcombe PJ, Bang H, Mueller DL, Catrina AI, Grönwall C, Skriner K, Nilsson P, Lightwood D, Klareskog L, Malmström V.
Arthritis Rheumatol. 2018 Aug 27. doi: 10.1002/art.40699. [Epub ahead of print]
PMID: 30152202
CCR7 defines a precursor for murine iNKT cells in thymus and periphery.
Wang H, Hogquist KA.
Elife. 2018 Aug 13;7. pii: e34793. doi: 10.7554/eLife.34793.
PMID: 30102153
Fecal Microbiota Transplantation: Current Status in Treatment of GI and Liver Disease.
Vaughn BP, Rank KM, Khoruts A.
Clin Gastroenterol Hepatol. 2018 Jul 25. pii: S1542-3565(18)30751-1. doi: 10.1016/j.cgh.2018.07.026. [Epub ahead of print] Review.
PMID:30055267
A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance.
Dutta R, Lunzer MM, Auger JL, Akgün E, Portoghese PS, Binstadt BA.
Arthritis Res Ther. 2018 Jul 27;20(1):154. doi: 10.1186/s13075-018-1661-5.
PMID:30053832
Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.
Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS.
Nature. 2018 Jul 18. doi: 10.1038/s41586-018-0345-2. [Epub ahead of print]
PMID: 30022164
Cutting Edge: Evidence for Nonvascular Route of Visceral Organ Immunosurveillance by T Cells.
Steinert EM, Thompson EA, Beura LK, Adam OA, Mitchell JS, Guo M, Breed ER, Sjaastad FV, Vezys V, Masopust D.
J Immunol. 2018 Jul 15;201(2):337-342. doi: 10.4049/jimmunol.1800279. Epub 2018 Jun 6.
PMID: 29875151
The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells.
Borges da Silva H, Beura LK, Wang H, Hanse EA, Gore R, Scott MC, Walsh DA, Block KE, Fonseca R, Yan Y, Hippen KL, Blazar BR, Masopust D, Kelekar A, Vulchanova L, Hogquist KA, Jameson SC.
Nature. 2018 Jul 4. doi: 10.1038/s41586-018-0282-0. [Epub ahead of print]
PMID: 29973721
For T Cells, the Child Is Father of the Man.
Hogquist KA, Hamilton SE.
Cell. 2018 Jun 28;174(1):16-18. doi: 10.1016/j.cell.2018.06.015.
PMID: 29958105
How Lipid-Specific T Cells Become Effectors: The Differentiation of iNKT Subsets.
Wang H, Hogquist KA.
Front Immunol. 2018 Jun 26;9:1450. doi: 10.3389/fimmu.2018.01450. eCollection 2018. Review.
PMID: 29997620
The virtuous self-tolerance of virtual memory T cells.
Truckenbrod EN, Jameson SC.
EMBO J. 2018 Jun 26. pii: e99883. doi: 10.15252/embj.201899883. [Epub ahead of print] No abstract available.
PMID:29946017
Pathogenic citrulline-multispecific B cell receptor clades in rheumatoid arthritis.
Titcombe PJ, Wigerblade G, Sippl N, Zhang N, Shmagel AK, Sahlström P, Zhang Y, Barsness LO, Ghodke-Puranik Y, Baharpoor A, Hansson M, Israelsson L, Skriner K, Niewold TB, Klareskog L, Svensson CI, Amara K, Malmström V, Mueller DL.
Arthritis Rheumatol. 2018 Jun 21. doi: 10.1002/art.40590. [Epub ahead of print]
PMID:29927106
Colorectal cancer mutational profiles correlate with defined microbial communities in the tumor microenvironment.
Burns MB, Montassier E, Abrahante J, Priya S, Niccum DE, Khoruts A, Starr TK, Knights D, Blekhman R.
PLoS Genet. 2018 Jun 20;14(6):e1007376. doi: 10.1371/journal.pgen.1007376. [Epub ahead of print]
PMID:29924794
CD301b/MGL2+ Mononuclear Phagocytes Orchestrate Autoimmune Cardiac Valve Inflammation and Fibrosis.
Meier LA, Auger JL, Engelson BJ, Cowan HM, Breed ER, Gonzalez-Torres MI, Boyer JD, Verma M, Marath A, Binstadt BA.
Circulation. 2018 Jun 5;137(23):2478-2493. doi: 10.1161/CIRCULATIONAHA.117.033144. Epub 2018 Jan 31.
PMID:29386201
Naive B Cells with High-Avidity Germline-Encoded Antigen Receptors Produce Persistent IgM+ and Transient IgG+ Memory B Cells.
Pape KA, Maul RW, Dileepan T, Paustian AS, Gearhart PJ, Jenkins MK.
Immunity. 2018 Jun 19;48(6):1135-1143.e4. doi: 10.1016/j.immuni.2018.04.019. Epub 2018 Jun 5.
PMID:29884459
Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue.
Buggert M, Nguyen S, Salgado-Montes de Oca G, Bengsch B, Darko S, Ransier A, Roberts ER, Del Alcazar D, Brody IB, Vella LA, Beura L, Wijeyesinghe S, Herati RS, Del Rio Estrada PM, Ablanedo-Terrazas Y, Kuri-Cervantes L, Sada Japp A, Manne S, Vartanian S, Huffman A, Sandberg JK, Gostick E, Nadolski G, Silvestri G, Canaday DH, Price DA, Petrovas C, Su LF, Vahedi G, Dori Y, Frank I, Itkin MG, Wherry EJ, Deeks SG, Naji A, Reyes-Terán G, Masopust D, Douek DC, Betts MR.
Sci Immunol. 2018 Jun 1;3(24). pii: eaar4526. doi: 10.1126/sciimmunol.aar4526.
PMID:29858286
Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes.
Osum KC, Burrack AL, Martinov T, Sahli NL, Mitchell JS, Tucker CG, Pauken KE, Papas K, Appakalai B, Spanier JA, Fife BT.
Sci Rep. 2018 May 29;8(1):8295. doi: 10.1038/s41598-018-26471-9.
PMID:29844327
Induction of vaginal-resident HIV-specific CD8 T cells with mucosal prime-boost immunization.
Tan HX, Wheatley AK, Esterbauer R, Jegaskanda S, Glass JJ, Masopust D, De Rose R, Kent SJ.
Mucosal Immunol. 2018 May;11(3):994-1007. doi: 10.1038/mi.2017.89. Epub 2017 Oct 25.
PMID:29067995
Identification of Cellular Sources of IL-2 Needed for Regulatory T Cell Development and Homeostasis.
Owen DL, Mahmud SA, Vang KB, Kelly RM, Blazar BR, Smith KA, Farrar MA.
J Immunol. 2018 May 4. pii: ji1800097. doi: 10.4049/jimmunol.1800097. [Epub ahead of print]
PMID:29728511
Duration of high-dose aspirin therapy does not affect long-term coronary artery outcomes in Kawasaki disease.
Migally K, Braunlin EA, Zhang L, Binstadt BA.
Pediatr Res. 2018 May 2. doi: 10.1038/pr.2018.44. [Epub ahead of print]
PMID:29554081
Is fecal microbiota transplantation a temporary patch for treatment of Clostridium difficile infection or a new frontier of therapeutics?
Khoruts A.
Expert Rev Gastroenterol Hepatol. 2018 May;12(5):435-438. doi: 10.1080/17474124.2018.1465818. Epub 2018 Apr 20.No abstract available.
PMID:29667436
Opioid Dose- and Route-Dependent Efficacy of Oxycodone and Heroin Vaccines in Rats.
Raleigh MD, Laudenbach M, Baruffaldi F, Peterson SJ, Roslawski MJ, Birnbaum AK, Carroll FI, Runyon SP, Winston S, Pentel PR, Pravetoni M.
J Pharmacol Exp Ther. 2018 May;365(2):346-353. doi: 10.1124/jpet.117.247049. Epub 2018 Mar 13.
PMID:29535156
The Contribution of Autoantibodies to Inflammatory Cardiovascular Pathology.
Meier LA, Binstadt BA.
Front Immunol. 2018 Apr 27;9:911. doi: 10.3389/fimmu.2018.00911. eCollection 2018. Review.
PMID: 29755478
Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset.
Hülsdünker J, Ottmüller KJ, Neeff HP, Koyama M, Gao Z, Thomas OS, Follo M, Al-Ahmad A, Prinz G, Duquesne S, Dierbach H, Kirschnek S, Lämmermann T, Blaser MJ, Fife BT, Blazar BR, Beilhack A, Hill GR, Häcker G, Zeiser R.
Blood. 2018 Apr 19;131(16):1858-1869. doi: 10.1182/blood-2017-10-812891. Epub 2018 Feb 20.
PMID:29463561
Blocking interleukin-4 enhances efficacy of vaccines for treatment of opioid abuse and prevention of opioid overdose.
Laudenbach M, Baruffaldi F, Robinson C, Carter P, Seelig D, Baehr C, Pravetoni M.
Sci Rep. 2018 Apr 3;8(1):5508. doi: 10.1038/s41598-018-23777-6.
PMID:29615715
What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans? Reevaluating the Potential of Mouse Models for the Human Immune System.
Jameson SC, Masopust D.
Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4). pii: a029132. doi: 10.1101/cshperspect.a029132. Review.
PMID:28348039
Regulatory CD4+ T Cells Recognize MHC-II-Restricted Peptide Epitopes of Apolipoprotein B.
Kimura T, Kobiyama K, Winkels H, Tse K, Miller J, Vassallo M, Wolf D, Ryden C, Orecchioni M, Dileepan T, Jenkins MK, James EA, Kwok WW, Hanna DB, Kaplan RC, Strickler HD, Durkin HG, Kassaye SG, Karim R, Tien PC, Landay AL, Gange SJ, Sidney J, Sette A, Ley K.
Circulation. 2018 Mar 27. pii: CIRCULATIONAHA.117.031420. doi: 10.1161/CIRCULATIONAHA.117.031420. [Epub ahead of print]
PMID:29588316
Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells.
Burrack KS, Huggins MA, Taras E, Dougherty P, Henzler CM, Yang R, Alter S, Jeng EK, Wong HC, Felices M, Cichocki F, Miller JS, Hart GT, Johnson AJ, Jameson SC, Hamilton SE.
Immunity. 2018 Mar 20. pii: S1074-7613(18)30088-8. doi: 10.1016/j.immuni.2018.03.012. [Epub ahead of print]
PMID:29625893
Many Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential.
Kotov DI, Kotov JA, Goldberg MF, Jenkins MK.
J Immunol. 2018 Mar 15;200(6):2004-2012. doi: 10.4049/jimmunol.1700420. Epub 2018 Feb 7.
PMID:29436413
Inflammatory arthritis in pediatric patients with morphea.
Kashem SW, Correll CK, Vehe RK, Hobday PM, Binstadt BA, Maguiness SM.
J Am Acad Dermatol. 2018 Mar 10. pii: S0190-9622(18)30365-7. doi: 10.1016/j.jaad.2018.03.005. [Epub ahead of print]
PMID:29535035
Antibiotic-induced Disruption of Intestinal Microbiota Contributes to Failure of Vertical Sleeve Gastrectomy.
Jahansouz C, Staley C, Kizy S, Xu H, Hertzel AV, Coryell J, Singroy S, Hamilton M, DuRand M, Bernlohr DA, Sadowsky MJ, Khoruts A, Ikramuddin S.
Ann Surg. 2018 Mar 8. doi: 10.1097/SLA.0000000000002729. [Epub ahead of print]
PMID:29521742
Variable domain N-linked glycosylation and negative surface charge are key features of monoclonal ACPA: implications for B-cell selection.
Lloyd KA, Steen J, Amara K, Titcombe PJ, Israelsson L, Lundström SL, Zhou D, Zubarev RA, Reed E, Piccoli L, Gabay C, Lanzavecchia A, Baeten D, Lundberg K, Mueller DL, Klareskog L, Malmström V, Grönwall C.
Eur J Immunol. 2018 Mar 7. doi: 10.1002/eji.201747446. [Epub ahead of print]
PMID: 29512823
Intravenous Labeling and Analysis of the Content of Thymic Perivascular Spaces.
Ruscher R, Hogquist KA.
Bio Protoc. 2018 Mar 5;8(5). pii: e2757. doi: 10.21769/bioprotoc.2757.
PMID: 29644257
RelB-Deficient Dendritic Cells Promote the Development of Spontaneous Allergic Airway Inflammation.
Nair PM, Starkey MR, Haw TJ, Ruscher R, Liu G, Maradana MR, Thomas R, O'Sullivan BJ, Hansbro PM.
Am J Respir Cell Mol Biol. 2018 Mar;58(3):352-365. doi: 10.1165/rcmb.2017-0242OC.
PMID:28960101
A Howling Cause of Pancytopenia.
Casciato A, Lind C, Olson APJ, Binstadt BA, Davis AM.
J Hosp Med. 2018 Mar 1;13(3):205-209. doi: 10.12788/jhm.2855. Epub 2017 Oct 4. No abstract available.
PMID: 29069118
T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells.
Beura LK, Wijeyesinghe S, Thompson EA, Macchietto MG, Rosato PC, Pierson MJ, Schenkel JM, Mitchell JS, Vezys V, Fife BT, Shen S, Masopust D.
Immunity. 2018 Feb 20;48(2):327-338.e5. doi: 10.1016/j.immuni.2018.01.015.
PMID: 29466758
Understanding Subset Diversity in T Cell Memory.
Jameson SC, Masopust D.
Immunity. 2018 Feb 20;48(2):214-226. doi: 10.1016/j.immuni.2018.02.010. Review.
PMID: 29466754
Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory.
Beura LK, Mitchell JS, Thompson EA, Schenkel JM, Mohammed J, Wijeyesinghe S, Fonseca R, Burbach BJ, Hickman HD, Vezys V, Fife BT, Masopust D.
Nat Immunol. 2018 Feb;19(2):173-182. doi: 10.1038/s41590-017-0029-3. Epub 2018 Jan 8.
PMID: 29311694
Strain Tracking Reveals the Determinants of Bacterial Engraftment in the Human Gut Following Fecal Microbiota Transplantation.
Smillie CS, Sauk J, Gevers D, Friedman J, Sung J, Youngster I, Hohmann EL, Staley C, Khoruts A, Sadowsky MJ, Allegretti JR, Smith MB, Xavier RJ, Alm EJ.
Cell Host Microbe. 2018 Feb 14;23(2):229-240.e5. doi: 10.1016/j.chom.2018.01.003.
PMID:29447696
Role of afferent and efferent renal nerves in the development of AngII-salt hypertension in rats.
Foss JD, Fiege J, Shimizu Y, Collister JP, Mayerhofer T, Wood L, Osborn JW.
Physiol Rep. 2018 Feb;6(3). doi: 10.14814/phy2.13602.
PMID:29405658
Cystic Fibrosis Colorectal Cancer Screening Consensus Recommendations.
Hadjiliadis D, Khoruts A, Zauber AG, Hempstead SE, Maisonneuve P, Lowenfels AB; Cystic Fibrosis Colorectal Cancer Screening Task Force.
Gastroenterology. 2018 Feb;154(3):736-745.e14. doi: 10.1053/j.gastro.2017.12.012. Epub 2017 Dec 29.
PMID:29289528
Cutting Edge: Allograft Rejection Is Associated with Weak T Cell Responses to Many Different Graft Leukocyte-Derived Peptides.
Burrack AL, Malhotra D, Dileepan T, Osum KC, Swanson LA, Fife BT, Jenkins MK.
J Immunol. 2018 Jan 15;200(2):477-482. doi: 10.4049/jimmunol.1701434. Epub 2017 Dec 18.
PMID: 29255075
Cutting Edge: Allograft Rejection Is Associated with Weak T Cell Responses to Many Different Graft Leukocyte-Derived Peptides.
Burrack AL, Malhotra D, Dileepan T, Osum KC, Swanson LA, Fife BT, Jenkins MK.
J Immunol. 2018 Jan 15;200(2):477-482. doi: 10.4049/jimmunol.1701434. Epub 2017 Dec 18.
PMID:29255075
Do Memory B Cells Form Secondary Germinal Centers? It Depends.
Pape KA, Jenkins MK.
Cold Spring Harb Perspect Biol. 2018 Jan 2;10(1). pii: a029116. doi: 10.1101/cshperspect.a029116. Review.
PMID: 28320756
Functional Genomics of Host-Microbiome Interactions in Humans.
Luca F, Kupfer SS, Knights D, Khoruts A, Blekhman R.
Trends Genet. 2018 Jan;34(1):30-40. doi: 10.1016/j.tig.2017.10.001. Epub 2017 Oct 26. Review.
PMID: 29107345