Publications
The Center for Immunology produces an immense amount of research each year. The data produced is comprehensive and timely to research across the globe. Our research is supported by Government, Commercial and Industrial grants and private funds and is produced in our state of the art research facilities. The research is carried out by faculty members, visiting scholars, post-doctoral fellows, graduate, and undergraduate students and technicians. The Center for Immunology also has a strong collaboration history with colleagues at other Universities and research companies worldwide.
To honor Center for Immunology faculty with 200 or more citations on one paper we have created our wall of honor.
2019 publications
Early childhood education is critical for Treg cells.
Salgado OC, Hogquist KA.
Nat Immunol. 2019 Jul 15. doi: 10.1038/s41590-019-0440-z. [Epub ahead of print] No abstract available.
PMID:31308543
Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells.
Brian BF, Jolicoeur AS, Guerrero CR, Nunez MG, Sychev ZE, Hegre SA, Sætrom P, Habib N, Drake JM, Schwertfeger KL, Freedman TS.
Elife. 2019 Jul 8;8. pii: e46043. doi: 10.7554/eLife.46043. [Epub ahead of print]
PMID:31282857
7-Methylation of Chenodeoxycholic Acid Derivatives Yields a Substantial Increase in TGR5 Receptor Potency.
Nakhi A, McDermott CM, Stoltz KL, John K, Hawkinson JE, Ambrose EA, Khoruts A, Sadowsky MJ, Dosa PI.
J Med Chem. 2019 Jul 3. doi: 10.1021/acs.jmedchem.9b00770. [Epub ahead of print]
PMID: 31268316
The Functional Requirement for CD69 in Establishment of Resident Memory CD8+ T Cells Varies with Tissue Location.
Walsh DA, Borges da Silva H, Beura LK, Peng C, Hamilton SE, Masopust D, Jameson SC.
J Immunol. 2019 Jun 26. pii: ji1900052. doi: 10.4049/jimmunol.1900052. [Epub ahead of print]
PMID:31243092
The Impact of TCR Signal Strength on Resident Memory T Cell Formation during Influenza Virus Infection.
Fiege JK, Stone IA, Fay EJ, Markman MW, Wijeyesinghe S, Macchietto MG, Shen S, Masopust D, Langlois RA.
J Immunol. 2019 Jun 24. pii: ji1900093. doi: 10.4049/jimmunol.1900093. [Epub ahead of print]
PMID:31235552
Evolutionarily conserved resistance to phagocytosis observed in melanoma cells is insensitive to upregulation of pro-phagocytic signals and to CD47 blockade.
Anderson KL, Snyder KM, Ito D, Lins DC, Mills LJ, Weiskopf K, Ring NG, Ring AM, Shimizu Y, Mescher MF, Weissman IL, Modiano JF.
Melanoma Res. 2019 Jun 12. doi: 10.1097/CMR.0000000000000629. [Epub ahead of print]
PMID: 31205227
Fecal Microbiota Transplant: A Rose by Any Other Name.
Khoruts A, Brandt LJ.
Am J Gastroenterol. 2019 Jun 14. doi: 10.14309/ajg.0000000000000286. [Epub ahead of print] No abstract available.
PMID: 31205129
Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria.
Hart GT, Tran TM, Theorell J, Schlums H, Arora G, Rajagopalan S, Sangala ADJ, Welsh KJ, Traore B, Pierce SK, Crompton PD, Bryceson YT, Long EO.
J Exp Med. 2019 Jun 3;216(6):1280-1290. doi: 10.1084/jem.20181681. Epub 2019 Apr 12.
PMID:30979790
BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors.
Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK.
J Exp Med. 2019 Jun 3;216(6):1450-1464. doi: 10.1084/jem.20182376. Epub 2019 May 3.
PMID: 31053612
JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors.
Irey EA, Lassiter CM, Brady NJ, Chuntova P, Wang Y, Knutson TP, Henzler C, Chaffee TS, Vogel RI, Nelson AC, Farrar MA, Schwertfeger KL.
Proc Natl Acad Sci U S A. 2019 May 30. pii: 201816410. doi: 10.1073/pnas.1816410116. [Epub ahead of print]
PMID:31147469
Cytomegalovirus evades TRAIL-mediated innate lymphoid cell 1 defenses.
Picarda G, Ghosh R, McDonald B, Verma S, Thiault N, El Morabiti R, Griffith TS, Benedict CA.
J Virol. 2019 May 29. pii: JVI.00617-19. doi: 10.1128/JVI.00617-19. [Epub ahead of print]
PMID:31142671
Development, ontogeny, and maintenance of TCRαβ+ CD8αα IEL.
Ruscher R, Hogquist KA.
Curr Opin Immunol. 2019 May 27;58:83-88. doi: 10.1016/j.coi.2019.04.010. [Epub ahead of print] Review.
PMID:31146182
Risk Factors for Development of Canine and Human Osteosarcoma: A Comparative Review.
Makielski KM, Mills LJ, Sarver AL, Henson MS, Spector LG, Naik S, Modiano JF.
Vet Sci. 2019 May 25;6(2). pii: E48. doi: 10.3390/vetsci6020048. Review.
PMID:31130627
Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8+ T Cells.
Hirai T, Zenke Y, Yang Y, Bartholin L, Beura LK, Masopust D, Kaplan DH.
Immunity. 2019 May 21;50(5):1249-1261.e5. doi: 10.1016/j.immuni.2019.03.002. Epub 2019 Apr 2.
PMID:30952606
Editorial: Fresh Ideas, Foundational Experiments: Immunology and Diabetes.
Spanier JA, Tse HM, Horwitz MS, Fife BT.
Front Endocrinol (Lausanne). 2019 May 16;10:315. doi: 10.3389/fendo.2019.00315. eCollection 2019. No abstract available.
PMID:31156560
CD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responses.
Beura LK, Fares-Frederickson NJ, Steinert EM, Scott MC, Thompson EA, Fraser KA, Schenkel JM, Vezys V, Masopust D.
J Exp Med. 2019 May 6;216(5):1214-1229. doi: 10.1084/jem.20181365. Epub 2019 Mar 28
PMID:30923043
Tetrahydrocannabinol Reduces Hapten-Driven Mast Cell Accumulation and Persistent Tactile Sensitivity in Mouse Model of Allergen-Provoked Localized Vulvodynia.
Boo B, Kamath R, Arriaga-Gomez E, Landry J, Emanuel E, Joo S, Saldías Montivero M, Martinov T, Fife BT, Chatterjea D.
Int J Mol Sci. 2019 May 1;20(9). pii: E2163. doi: 10.3390/ijms20092163.
PMID: 31052404
TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.
Kotov DI, Mitchell JS, Pengo T, Ruedl C, Way SS, Langlois RA, Fife BT, Jenkins MK.
J Immunol. 2019 May 1;202(9):2535-2545. doi: 10.4049/jimmunol.1801609. Epub 2019 Mar 11.
PMID: 30858199
Dendritic cell NLRC4 regulates influenza A virus-specific CD4 T cell responses through FasL expression.
Hornick EE, Dagvadorj J, Zacharias ZR, Miller AM, Langlois RA, Chen P, Legge KL, Bishop GA, Sutterwala FS, Cassel SL.
J Clin Invest. 2019 Apr 30;130. pii: 124937. doi: 10.1172/JCI124937.
PMID:31038471
Peptide:MHCII Tetramer-Based Cell Enrichment for the Study of Epitope-Specific CD4+ T Cells.
Kotov DI, Jenkins MK.
Curr Protoc Immunol. 2019 Apr 29:e75. doi: 10.1002/cpim.75. [Epub ahead of print]
PMID: 31034767
Tissue-Resident T Cells and Other Resident Leukocytes.
Masopust D, Soerens AG.
Annu Rev Immunol. 2019 Apr 26;37:521-546. doi: 10.1146/annurev-immunol-042617-053214. Epub 2019 Feb 6.
PMID: 30726153
Differential effects of depleting versus programming tumor-associated macrophages on engineered T cells in pancreatic ductal adenocarcinoma.
Stromnes IM, Burrack AL, Hulbert A, Bonson P, Black C, Brockenbrough JS, Raynor JF, Spartz EJ, Pierce RH, Greenberg PD, Hingorani SR.
Cancer Immunol Res. 2019 Apr 26. pii: canimm.0448.2018. doi: 10.1158/2326-6066.CIR-18-0448. [Epub ahead of print]
PMID: 31028033
Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance.
Martinov T, Fife BT.
Ann N Y Acad Sci. 2019 Apr 26. doi: 10.1111/nyas.14106. [Epub ahead of print] Review.
PMID: 31025378
Measuring Thymic Clonal Deletion at the Population Level.
Breed ER, Watanabe M, Hogquist KA.
J Immunol. 2019 Apr 22. pii: ji1900191. doi: 10.4049/jimmunol.1900191. [Epub ahead of print]
PMID: 31010850
A comparison of risk factors for metastasis at diagnosis in humans and dogs with osteosarcoma.
Diessner BJ, Marko TA, Scott RM, Eckert AL, Stuebner KM, Hohenhaus AE, Selting KA, Largaespada DA, Modiano JF, Spector LG.
Cancer Med. 2019 Apr 21. doi: 10.1002/cam4.2177. [Epub ahead of print]
PMID: 31006987
Dysbiosis patterns during re-induction/salvage versus induction chemotherapy for acute leukemia.
Rashidi A, Kaiser T, Shields-Cutler R, Graiziger C, Holtan SG, Rehman TU, Wasko J, Weisdorf DJ, Dunny G, Khoruts A, Staley C.
Sci Rep. 2019 Apr 15;9(1):6083. doi: 10.1038/s41598-019-42652-6.
PMID: 30988420
Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria.
Hart GT, Tran TM, Theorell J, Schlums H, Arora G, Rajagopalan S, Sangala ADJ, Welsh KJ, Traore B, Pierce SK, Crompton PD, Bryceson YT, Long EO.
J Exp Med. 2019 Apr 12. pii: jem.20181681. doi: 10.1084/jem.20181681. [Epub ahead of print]
PMID: 30979790
ARTC2.2/P2RX7 Signaling during Cell Isolation Distorts Function and Quantification of Tissue-Resident CD8+ T Cell and Invariant NKT Subsets.
Borges da Silva H, Wang H, Qian LJ, Hogquist KA, Jameson SC.
J Immunol. 2019 Apr 1;202(7):2153-2163. doi: 10.4049/jimmunol.1801613. Epub 2019 Feb 18.
PMID: 30777922
Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8+ T Cells.
Hirai T, Zenke Y, Yang Y, Bartholin L, Beura LK, Masopust D, Kaplan DH.
Immunity. 2019 Mar 23. pii: S1074-7613(19)30092-5. doi: 10.1016/j.immuni.2019.03.002. [Epub ahead of print]
PMID: 30952606
Interstitial Migration of CD8αβ T Cells in the Small Intestine Is Dynamic and Is Dictated by Environmental Cues.
Thompson EA, Mitchell JS, Beura LK, Torres DJ, Mrass P, Pierson MJ, Cannon JL, Masopust D, Fife BT, Vezys V.
Cell Rep. 2019 Mar 12;26(11):2859-2867.e4. doi: 10.1016/j.celrep.2019.02.034.
PMID:30865878
Noninvasive ultrasound stimulation of the spleen to treat inflammatory arthritis.
Zachs DP, Offutt SJ, Graham RS, Kim Y, Mueller J, Auger JL, Schuldt NJ, Kaiser CRW, Heiller AP, Dutta R, Guo H, Alford JK, Binstadt BA, Lim HH.
Nat Commun. 2019 Mar 12;10(1):951. doi: 10.1038/s41467-019-08721-0.
PMID:30862842
Combination of Sunitinib and PD-L1 Blockade Enhances Anticancer Efficacy of TLR7/8 Agonist-Based Nanovaccine.
Kim H, Khanna V, Kucaba TA, Zhang W, Ferguson DM, Griffith TS, Panyam J.
Mol Pharm. 2019 Mar 4;16(3):1200-1210. doi: 10.1021/acs.molpharmaceut.8b01165. Epub 2019 Jan 25.
PMID: 30620878
Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques.
Petitdemange C, Kasturi SP, Kozlowski PA, Nabi R, Quarnstrom CF, Reddy PBJ, Derdeyn CA, Spicer LM, Patel P, Legere T, Kovalenkov YO, Labranche CC, Villinger F, Tomai M, Vasilakos J, Haynes B, Kang CY, Gibbs JS, Yewdell JW, Barouch D, Wrammert J, Montefiori D, Hunter E, Amara RR, Masopust D, Pulendran B.
JCI Insight. 2019 Feb 21;4(4). pii: 126047. doi: 10.1172/jci.insight.126047. eCollection 2019 Feb 21.
PMID:30830870
Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function.
Dumm RE, Fiege JK, Waring BM, Kuo CT, Langlois RA, Heaton NS.
Nat Commun. 2019 Feb 15;10(1):779. doi: 10.1038/s41467-019-08617-z.
PMID: 30770807
Reprogramming responsiveness to checkpoint blockade in dysfunctional CD8 T cells.
Nelson CE, Mills LJ, McCurtain JL, Thompson EA, Seelig DM, Bhela S, Quarnstrom CF, Fife BT, Vezys V.
Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2640-2645. doi: 10.1073/pnas.1810326116. Epub 2019 Jan 24.
PMID: 30679280
Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy.
Rosato PC, Wijeyesinghe S, Stolley JM, Nelson CE, Davis RL, Manlove LS, Pennell CA, Blazar BR, Chen CC, Geller MA, Vezys V, Masopust D.
Nat Commun. 2019 Feb 4;10(1):567. doi: 10.1038/s41467-019-08534-1.
PMID: 30718505
Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma.
Rahrmann EP, Wolf NK, Otto GM, Heltemes-Harris L, Ramsey LB, Shu J, LaRue RS, Linden MA, Rathe SK, Starr TK, Farrar MA, Moriarity BS, Largaespada DA.
Mol Cancer Res. 2019 Feb;17(2):567-582. doi: 10.1158/1541-7786.MCR-18-0582. Epub 2018 Oct 24.
PMID: 30355676
Dual TCR T Cells: Identity Crisis or Multitaskers?
Schuldt NJ, Binstadt BA.
J Immunol. 2019 Feb 1;202(3):637-644. doi: 10.4049/jimmunol.1800904. Review.
PMID: 30670579
A Fentanyl Vaccine Alters Fentanyl Distribution and Protects against Fentanyl-Induced Effects in Mice and Rats.
Raleigh MD, Baruffaldi F, Peterson SJ, Le Naour M, Harmon TM, Vigliaturo JR, Pentel PR, Pravetoni M.
J Pharmacol Exp Ther. 2019 Feb;368(2):282-291. doi: 10.1124/jpet.118.253674. Epub 2018 Nov 8.
PMID: 30409833
Thymic regulatory T cells arise via two distinct developmental programs.
Owen DL, Mahmud SA, Sjaastad LE, Williams JB, Spanier JA, Simeonov DR, Ruscher R, Huang W, Proekt I, Miller CN, Hekim C, Jeschke JC, Aggarwal P, Broeckel U, LaRue RS, Henzler CM, Alegre ML, Anderson MS, August A, Marson A, Zheng Y, Williams CB, Farrar MA.
Nat Immunol. 2019 Feb;20(2):195-205. doi: 10.1038/s41590-018-0289-6. Epub 2019 Jan 14.
PMID: 30643267
Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade.
Wang Z, Aguilar EG, Luna JI, Dunai C, Khuat LT, Le CT, Mirsoian A, Minnar CM, Stoffel KM, Sturgill IR, Grossenbacher SK, Withers SS, Rebhun RB, Hartigan-O'Connor DJ, Méndez-Lagares G, Tarantal AF, Isseroff RR, Griffith TS, Schalper KA, Merleev A, Saha A, Maverakis E, Kelly K, Aljumaily R, Ibrahimi S, Mukherjee S, Machiorlatti M, Vesely SK, Longo DL, Blazar BR, Canter RJ, Murphy WJ, Monjazeb AM.
Nat Med. 2019 Jan;25(1):141-151. doi: 10.1038/s41591-018-0221-5. Epub 2018 Nov 12.
PMID: 30420753
Engineering T cell response to cancer antigens by choice of focal therapeutic conditions.
Shao Q, O'Flanagan S, Lam T, Roy P, Pelaez F, Burbach BJ, Azarin SM, Shimizu Y, Bischof JC.
Int J Hyperthermia. 2019 Jan 24:1-9. doi: 10.1080/02656736.2018.1539253. [Epub ahead of print]
PMID: 30676126
The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation.
Liu B, Salgado OC, Singh S, Hippen KL, Maynard JC, Burlingame AL, Ball LE, Blazar BR, Farrar MA, Hogquist KA, Ruan HB.
Nat Commun. 2019 Jan 21;10(1):354. doi: 10.1038/s41467-019-08300-3.
PMID:30664665
Cutting Edge: T Cell-Dependent Plasmablasts Form in the Absence of Single Differentiated CD4+ T Cell Subsets.
Kotov JA, Jenkins MK.
J Immunol. 2019 Jan 15;202(2):401-405. doi: 10.4049/jimmunol.1801349. Epub 2018 Dec 14.
PMID: 30552165
Autoantibodies in the Pathogenesis, Diagnosis, and Prognosis of Juvenile Idiopathic Arthritis.
Mahmud SA, Binstadt BA.
Front Immunol. 2019 Jan 14;9:3168. doi: 10.3389/fimmu.2018.03168. eCollection 2018. Review.
PMID: 30693002
Alum adjuvant is more effective than MF59 at prompting early germinal center formation in response to peptide-protein conjugates and enhancing efficacy of a vaccine against opioid use disorders.
Robinson C, Baehr C, Schmiel SE, Accetturo C, Mueller DL, Pravetoni M.
Hum Vaccin Immunother. 2019 Jan 9. doi: 10.1080/21645515.2018.1558697. [Epub ahead of print]
PMID: 30625019
Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis.
Lloyd KA, Wigerblad G, Sahlström P, Garimella MG, Chemin K, Steen J, Titcombe PJ, Marklein B, Zhou D, Stålesen R, Ossipova E, Lundqvist C, Ekwall O, Rönnelid J, Mueller DL, Karlsson MCI, Kaplan MJ, Skriner K, Klareskog L, Wermeling F, Malmström V, Grönwall C.
Front Immunol. 2019 Jan 4;9:3033. doi: 10.3389/fimmu.2018.03033. eCollection 2018.
PMID:30662440
Fecal Microbiota Transplantation: Current Status in Treatment of GI and Liver Disease.
Vaughn BP, Rank KM, Khoruts A.
Clin Gastroenterol Hepatol. 2019 Jan;17(2):353-361. doi: 10.1016/j.cgh.2018.07.026. Epub 2018 Jul 25. Review.
PMID: 30055267
Chrysalis: A New Method for High-Throughput Histo-Cytometry Analysis of Images and Movies.
Kotov DI, Pengo T, Mitchell JS, Gastinger MJ, Jenkins MK.
J Immunol. 2019 Jan 1;202(1):300-308. doi: 10.4049/jimmunol.1801202. Epub 2018 Dec 3.
PMID: 30510065
Embracing microbial exposure in mouse research.
Huggins MA, Jameson SC, Hamilton SE.
J Leukoc Biol. 2019 Jan;105(1):73-79. doi: 10.1002/JLB.4RI0718-273R. Epub 2018 Sep 27. Review.
PMID: 30260516
Vaccines to treat opioid use disorders and to reduce opioid overdoses.
Baehr C, Pravetoni M.
Neuropsychopharmacology. 2019 Jan;44(1):217-218. doi: 10.1038/s41386-018-0197-3. No abstract available.
PMID: 30405185