Publications

The Center for Immunology produces an immense amount of research each year.  The data produced is comprehensive and timely to research across the globe.  Our research is supported by Government, Commercial and Industrial grants and private funds and is produced in our state of the art research facilities.  The research is carried out by faculty members, visiting scholars, post-doctoral fellows, graduate, and undergraduate students and technicians. The Center for Immunology also has a strong collaboration history with colleagues at other Universities and research companies worldwide.

 To honor the Center for Immunology faculty with 200 or more citations on one paper we have created our wall of honor. 

View the Wall of Honor

2021 publications

ACKR4 in Tumor Cells Regulates Dendritic Cell Migration to Tumor-Draining Lymph Nodes and T-Cell Priming.
Wangmo D, Premsrirut PK, Yuan C, Morris WS, Zhao X, Subramanian S.
Cancers (Basel). 2021 Oct 7;13(19):5021. doi: 10.3390/cancers13195021.
PMID: 34638505

Phenotypic and Functional Diversity in Regulatory T Cells.
Sjaastad LE, Owen DL, Tracy SI, Farrar MA.
Front Cell Dev Biol. 2021 Sep 23;9:715901. doi: 10.3389/fcell.2021.715901. eCollection 2021.
PMID: 34631704

High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines.
Pape KA, Dileepan T, Kabage AJ, Kozysa D, Batres R, Evert C, Matson M, Lopez S, Krueger PD, Graiziger C, Vaughn BP, Shmidt E, Rhein J, Schacker TW, Khoruts A, Jenkins MK.
Cell Rep. 2021 Sep 25:109823. doi: 10.1016/j.celrep.2021.109823. Online ahead of print.
PMID: 34610291

Regulation of myeloid-cell activation.
Greene JT, Brian BF 4th, Senevirathne SE, Freedman TS.
Curr Opin Immunol. 2021 Sep 30;73:34-42. doi: 10.1016/j.coi.2021.09.004. Online ahead of print.
PMID: 34601225

Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia.
Heltemes-Harris LM, Hubbard GK, LaRue RS, Munro SA, Yang R, Henzler CM, Starr TK, Sarver AL, Kornblau SM, Farrar MA.
Oncogene. 2021 Sep 17. doi: 10.1038/s41388-021-02012-z. Online ahead of print.
PMID: 34535769

Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection.
Geng Q, Tai W, Baxter VK, Shi J, Wan Y, Zhang X, Montgomery SA, Taft-Benz SA, Anderson EJ, Knight AC, Dinnon KH 3rd, Leist SR, Baric RS, Shang J, Hong SW, Drelich A, Tseng CK, Jenkins M, Heise M, Du L, Li F.
PLoS Pathog. 2021 Sep 7;17(9):e1009897. doi: 10.1371/journal.ppat.1009897. Online ahead of print.
PMID: 34492082

Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning.
Makielski KM, Donnelly AJ, Khammanivong A, Scott MC, Ortiz AR, Galvan DC, Tomiyasu H, Amaya C, Ward KA, Montoya A, Garbe JR, Mills LJ, Cutter GR, Fenger JM, Kisseberth WC, O'Brien TD, Weigel BJ, Spector LG, Bryan BA, Subramanian S, Modiano JF.
Lab Invest. 2021 Sep 6. doi: 10.1038/s41374-021-00655-w. Online ahead of print.
PMID: 34489559

Brown adipose tissue monocytes support tissue expansion.
Gallerand A, Stunault MI, Merlin J, Luehmann HP, Sultan DH, Firulyova MM, Magnone V, Khedher N, Jalil A, Dolfi B, Castiglione A, Dumont A, Ayrault M, Vaillant N, Gilleron J, Barbry P, Dombrowicz D, Mack M, Masson D, Bertero T, Becher B, Williams JW, Zaitsev K, Liu Y, Guinamard RR, Yvan-Charvet L, Ivanov S.
Nat Commun. 2021 Sep 6;12(1):5255. doi: 10.1038/s41467-021-25616-1.
PMID: 34489438

The precursors of CD8⁺ tissue resident memory T cells: from lymphoid organs to infected tissues.
Kok L, Masopust D, Schumacher TN.
Nat Rev Immunol. 2021 Sep 3:1-11. doi: 10.1038/s41577-021-00590-3. Online ahead of print.
PMID: 34480118

Enhanced CD4⁺ and CD8⁺ T cell infiltrate within convex hull defined pancreatic islet borders as autoimmune diabetes progresses.
Alexander J. Dwyer, Jacob M. Ritz, Jason S. Mitchell, Tijana Martinov, Mohannad Alkhatib, Nubia Silva, Christopher G. Tucker, Brian T. Fife
Sci Rep. 2021 Aug 25;11(1):17142. doi: 10.1038/s41598-021-96327-2.
PMID: 34433860

IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2.
Goldberg EL, Shchukina I, Youm YH, Ryu S, Tsusaka T, Young KC, Camell CD, Dlugos T, Artyomov MN, Dixit VD.
Cell Metab. 2021 Aug 26:S1550-4131(21)00367-3. doi: 10.1016/j.cmet.2021.08.004. Online ahead of print.
PMID: 34473956

MHC class II tetramers engineered for enhanced binding to CD4 improve detection of antigen-specific T cells.
Dileepan T, Malhotra D, Kotov DI, Kolawole EM, Krueger PD, Evavold BD, Jenkins MK.
Nat Biotechnol. 2021 Aug;39(8):943-948. doi: 10.1038/s41587-021-00893-9. Epub 2021 May 3.
PMID: 33941928

Housing conditions and microbial environment do not affect the efficacy of vaccines for treatment of opioid use disorders in mice and rats.
Crouse B, Zhang L, Robinson C, Ban Y, Vigliaturo JR, Roy S, Pravetoni M.
Hum Vaccin Immunother. 2021 Aug 19:1-10. doi: 10.1080/21645515.2021.1954442. Online ahead of print.
PMID: 34411500

Metabolic regulation of macrophage proliferation and function in atherosclerosis.
Patterson MT, Williams JW.
Curr Opin Lipidol. 2021 Jul 28. doi: 10.1097/MOL.0000000000000778. Online ahead of print.
PMID: 34334628

Sepsis and multiple sclerosis: causative links and outcomes.   
Miljković Đ, Stanisavljević S, Jensen IJ, Griffith TS, Badovinac VP.
Immunol Lett. 2021 Jul 25:S0165-2478(21)00117-6. doi: 10.1016/j.imlet.2021.07.008. Online ahead of print.
PMID: 34320384

The Src-family kinase Lyn in immunoreceptor signaling.
Brian Iv BF, Freedman TS.
Endocrinology. 2021 Jul 28:bqab152. doi: 10.1210/endocr/bqab152. Online ahead of print.
PMID: 34320188

Contribution of Antibody-Mediated Effector Functions to the Mechanism of Efficacy of Vaccines for Opioid Use Disorders.
Huseby Kelcher AM, Baehr CA, Hamid FA, Hart GT, Pravetoni M.
J Immunol. 2021 Jul 19:ji2100204. doi: 10.4049/jimmunol.2100204. Online ahead of print.
PMID: 34281999

Inflating the role of stromal cells in CD8⁺ T cell memory.
Block KE, Jameson SC.
Nat Immunol. 2021 Jul 15. doi: 10.1038/s41590-021-00974-6. Online ahead of print.
PMID: 34267376

Can FMT cause or prevent CRC? Maybe, but there is more to consider.
Khoruts A.
Gastroenterology. 2021 Jul 2:S0016-5085(21)03230-3. doi: 10.1053/j.gastro.2021.06.074. Online ahead of print.
PMID: 34224741

A multi-center phase II randomized clinical trial of losartan on symptomatic outpatients with COVID-19.
Puskarich MA, Cummins NW, Ingraham NE, Wacker DA, Reilkoff RA, Driver BE, Biros MH, Bellolio F, Chipman JG, Nelson AC, Beckman K, Langlois R, Bold T, Aliota MT, Schacker TW, Voelker HT, Murray TA, Koopmeiners JS, Tignanelli CJ.
EClinicalMedicine. 2021 Jun 17;37:100957. doi: 10.1016/j.eclinm.2021.100957. eCollection 2021 Jul.
PMID: 34195577

Sepsis, Cytokine Storms, and Immunopathology: The Divide between Neonates and Adults.
Greenfield KG, Badovinac VP, Griffith TS, Knoop KA.
Immunohorizons. 2021 Jun 28;5(6):512-522. doi: 10.4049/immunohorizons.2000104.
PMID: 34183380

Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells.
Burbach BJ, O'Flanagan SD, Shao Q, Young KM, Slaughter JR, Rollins MR, Street TJL, Granger VE, Beura LK, Azarin SM, Ramadhyani S, Forsyth BR, Bischof JC, Shimizu Y.
Nat Commun. 2021 Jun 23;12(1):3862. doi: 10.1038/s41467-021-24132-6.
PMID: 34162858

Prolonged Reactive Oxygen Species Production following Septic Insult.
Jensen IJ, McGonagill PW, Berton RR, Wagner BA, Silva EE, Buettner GR, Griffith TS, Badovinac VP.
Immunohorizons. 2021 Jun 18;5(6):477-488. doi: 10.4049/immunohorizons.2100027.
PMID: 34145054

Pharmacological mechanisms underlying the efficacy of antibodies generated by a vaccine to treat oxycodone use disorder.
Raleigh MD, King SJ, Baruffaldi F, Saykao A, Hamid FA, Winston S, LeSage MG, Pentel PR, Pravetoni M.
Neuropharmacology. 2021 Jun 11:108653. doi: 10.1016/j.neuropharm.2021.108653. Online ahead of print.
PMID: 34126123

Exercise of high intensity ameliorates hepatic inflammation and the progression of NASH.
Fredrickson G, Barrow F, Dietsche K, Parthiban P, Khan S, Robert S, Demirchian M, Rhoades H, Wang H, Adeyi O, Revelo XS.
Mol Metab. 2021 Jun 9:101270. doi: 10.1016/j.molmet.2021.101270. Online ahead of print.
PMID: 34118476

Senolytics reduce coronavirus-related mortality in old mice.
Camell CD, Yousefzadeh MJ, Zhu Y, Langhi Prata LGP, Huggins MA, Pierson M, Zhang L, O'Kelly RD, Pirtskhalava T, Xun P, Ejima K, Xue A, Tripathi U, Machado Espindola-Netto J, Giorgadze N, Atkinson EJ, Inman CL, Johnson KO, Cholensky SH, Carlson TW, LeBrasseur NK, Khosla S, O'Sullivan MG, Allison DB, Jameson SC, Meves A, Li M, Prakash YS, Chiarella SE, Hamilton SE, Tchkonia T, Niedernhofer LJ, Kirkland JL, Robbins PD.
Science. 2021 Jun 8:eabe4832. doi: 10.1126/science.abe4832. Online ahead of print.
PMID: 34103349

Intranasal nanoparticle vaccination elicits a persistent, polyfunctional CD4 T cell response in the murine lung-specific for a highly conserved influenza antigen that are sufficient to mediate protection from influenza virus challenge.
Nelson SA, Dileepan T, Rasley A, Jenkins MK, Fischer NO, Sant AJ.
J Virol. 2021 Jun 2:JVI0084121. doi: 10.1128/JVI.00841-21. Online ahead of print.
PMID: 34076479

Structural modifications that increase gut restriction of bile acid derivatives.
Nakhi A, Wong HL, Weldy M, Khoruts A, Sadowsky MJ, Dosa PI.
RSC Med Chem. 2021 Feb 12;12(3):394-405. doi: 10.1039/d0md00425a. eCollection 2021 Mar 1.
PMID: 34046622

Fentanyl conjugate vaccine by injected or mucosal delivery with dmLT or LTA1 adjuvants implicates IgA in protection from drug challenge.
Stone AE, Scheuermann SE, Haile CN, Cuny GD, Velasquez ML, Linhuber JP, Duddupudi AL, Vigliaturo JR, Pravetoni M, Kosten TA, Kosten TR, Norton EB.
NPJ Vaccines. 2021 May 13;6(1):69. doi: 10.1038/s41541-021-00329-0.
PMID: 33986280

An aged immune system drives senescence and ageing of solid organs.
Yousefzadeh MJ, Flores RR, Zhu Y, Schmiechen ZC, Brooks RW, Trussoni CE, Cui Y, Angelini L, Lee KA, McGowan SJ, Burrack AL, Wang D, Dong Q, Lu A, Sano T, O'Kelly RD, McGuckian CA, Kato JI, Bank MP, Wade EA, Pillai SPS, Klug J, Ladiges WC, Burd CE, Lewis SE, LaRusso NF, Vo NV, Wang Y, Kelley EE, Huard J, Stromnes IM, Robbins PD, Niedernhofer LJ.
Nature. 2021 Jun;594(7861):100-105. doi: 10.1038/s41586-021-03547-7. Epub 2021 May 12.
PMID: 33981041

The Emerging Role of B Cells in the Pathogenesis of NAFLD.
Barrow F, Khan S, Wang H, Revelo XS.
Hepatology. 2021 May 7. doi: 10.1002/hep.31889. Online ahead of print.
PMID: 33961302

The Role of Programmed Death-1 in Type 1 Diabetes.
Tucker CG, Dwyer AJ, Fife BT, Martinov T.
Curr Diab Rep. 2021 May 6;21(6):20. doi: 10.1007/s11892-021-01384-6.
PMID: 33956235

Immunology Lessons from the SARS-CoV-2 Pandemic.
Yokoyama WM, Hogquist KA, O'Shea JJ.
Annu Rev Immunol. 2021 Apr 26;39:v-vii. doi: 10.1146/annurev-iy-39-030121-100001. Epub 2021 May 3.
PMID: 33939926

CD8⁺ T cell self-tolerance permits responsiveness but limits tissue damage.
Truckenbrod EN, Burrack KS, Knutson TP, Borges da Silva H, Block KE, O'Flanagan SD, Stagliano KR, Hurwitz AA, Fulton RB, Renkema KR, Jameson SC.
Elife. 2021 Apr 30;10:e65615. doi: 10.7554/eLife.65615. Online ahead of print.
PMID: 33929324

CD4⁺ Memory T-Cell Formation during Type 1 Immune Responses.
Krueger PD, Osum KC, Jenkins MK.
Cold Spring Harb Perspect Biol. 2021 Apr 26:a038141. doi: 10.1101/cshperspect.a038141. Online ahead of print.
PMID: 33903156

Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells.
Georgiev H, Peng C, Huggins MA, Jameson SC, Hogquist KA.
Nat Commun. 2021 Apr 16;12(1):2308. doi: 10.1038/s41467-021-22589-z.
PMID: 33863906

Two sequential activation modules control the differentiation of protective T helper-1 (Th1) cells.
Krueger PD, Goldberg MF, Hong SW, Osum KC, Langlois RA, Kotov DI, Dileepan T, Jenkins MK.
Immunity. 2021 Mar 23:S1074-7613(21)00118-7. doi: 10.1016/j.immuni.2021.03.006. Online ahead of print.
PMID: 33773107

Expansible residence decentralizes immune homeostasis.
Wijeyesinghe S, Beura LK, Pierson MJ, Stolley JM, Adam OA, Ruscher R, Steinert EM, Rosato PC, Vezys V, Masopust D.
Nature. 2021 Mar 17. doi: 10.1038/s41586-021-03351-3. Online ahead of print.
PMID: 33731934

Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses.
Joag V, Wijeyesinghe S, Stolley JM, Quarnstrom CF, Dileepan T, Soerens AG, Sangala JA, O'Flanagan SD, Gavil NV, Hong SW, Bhela S, Gangadhara S, Weyu E, Matchett WE, Thiede J, Krishna V, Cheeran MC, Bold TD, Amara R, Southern P, Hart GT, Schifanella L, Vezys V, Jenkins MK, Langlois RA, Masopust D.
 J Immunol. 2021 Mar 1;206(5):931-935. doi: 10.4049/jimmunol.2001400. Epub 2021 Jan 13.
PMID: 33441437

P2Y11: The CD4 T cell mitochondrial shepherd.
Borges da Silva H.
J Leukoc Biol. 2021 Mar;109(3):477-479. doi: 10.1002/JLB.2CE0620-240R. Epub 2020 Sep 2.
PMID: 32876961

Generating Mice with Diverse Microbial Experience.
Pierson M, Merley A, Hamilton SE.
Curr Protoc. 2021 Feb;1(2):e53. doi: 10.1002/cpz1.53.
PMID: 33621444

Microbiota-Driven Activation of Intrahepatic B Cells Aggravates Nonalcoholic Steatohepatitis through Innate and Adaptive Signaling.
Barrow F, Khan S, Fredrickson G, Wang H, Dietsche K, Parthiban P, Robert S, Kaiser T, Winer S, Herman A, Adeyi O, Mouzaki M, Khoruts A, Hogquist KA, Staley C, Winer DA, Revelo XS.
Hepatology. 2021 Feb 20. doi: 10.1002/hep.31755. Online ahead of print.
PMID: 33609303

A Picture is Worth A Thousand Words, but Only if it is a Good Picture.
Solomon DH, Binstadt BA, Felson DT, Nigrovic PA.
Arthritis Rheumatol. 2021 Feb 9. doi: 10.1002/art.41682. Online ahead of print.
PMID: 33559356

Novel TLR 7/8 agonists for improving NK cell mediated antibody-dependent cellular cytotoxicity (ADCC).
Khanna V, Kim H, Zhang W, Larson P, Shah M, Griffith TS, Ferguson D, Panyam J.
Sci Rep. 2021 Feb 8;11(1):3346. doi: 10.1038/s41598-021-83005-6.
PMID: 33558639

CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model.
Burrack AL, Rollins MR, Spartz EJ, Mesojednik TD, Schmiechen ZC, Raynor JF, Wang IX, Kedl RM, Stromnes IM.
J Immunol. 2021 Feb 8:ji2000765. doi: 10.4049/jimmunol.2000765. Online ahead of print.
PMID: 33558374

Initial determination of COVID-19 seroprevalence among outpatients and healthcare workers in Minnesota using a novel SARS-CoV-2 total antibody ELISA.
Thomas SN, Altawallbeh G, Zaun C, Pape K, Peters JM, Titcombe PJ, Dileepan T, Rapp MJ, Bold TD, Schacker TW, Arbefeville S, Ferrieri P, Thyagarajan B, Jenkins MK, Karger AB.
Clin Biochem. 2021 Feb 1:S0009-9120(21)00027-8. doi: 10.1016/j.clinbiochem.2021.01.010. Online ahead of print.
PMID: 33539808

Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers.
Lee JH, Hu JK, Georgeson E, Nakao C, Groschel B, Dileepan T, Jenkins MK, Seumois G,Vijayanand P, Schief WR,Crotty S.
J Exp Med. 2021 Feb 1;218(2):e20201254. doi: 10.1084/jem.20201254.
PMID: 33355623

MHC Class I on murine hematopoietic APC selects Type A IEL precursors in the thymus.
Lee ST, Georgiev H, Breed ER, Ruscher R, Hogquist KA.
Eur J Immunol. 2021 Jan 31. doi: 10.1002/eji.202048996. Online ahead of print.
PMID: 33521937

NK Cell-Derived IL-10 Supports Host Survival during Sepsis.
Jensen IJ, McGonagill PW, Butler NS, Harty JT, Griffith TS, Badovinac VP.
J Immunol. 2021 Jan 29:ji2001131. doi: 10.4049/jimmunol.2001131. Online ahead of print.
PMID: 33514512

Mechanisms Governing Immunotherapy Resistance in Pancreatic Ductal Adenocarcinoma.
Schmiechen ZC, Stromnes IM.
Front Immunol. 2021 Jan 28;11:613815. doi: 10.3389/fimmu.2020.613815. eCollection 2020.
PMID: 33584701

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium.
Fiege JK, Thiede JM, Nanda HA, Matchett WE, Moore PJ, Montanari NR, Thielen BK, Daniel J, Stanley E, Hunter RC, Menachery VD, Shen SS, Bold TD, Langlois RA.
PLoS Pathog. 2021 Jan 28;17(1):e1009292. doi: 10.1371/journal.ppat.1009292. Online ahead of print.
PMID: 3350795

SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with nonsevere disease.
Gniadek TJ, Thiede JM, Matchett WE, Gress AR, Pape KA, Fiege JK, Jenkins MK, Menachery VD, Langlois RA, Bold TD.
Transfusion. 2021 Jan;61(1):17-23. doi: 10.1111/trf.16101. Epub 2020 Oct 2.
PMID: 32935872

Immune profiling reveals early disease trajectories associated with COVID-19 mortality: a sub-study from the ACTT-1 trial.
Thiede JM, Gress AR, Libby SD, Ronayne CE, Matchett WE, Noren B, Billings JL, Menachery VD, Langlois RA, Kline S, Bold TD.
J Infect Dis. 2021 Jan 21:jiab035. doi: 10.1093/infdis/jiab035. Online ahead of print.
PMID: 33476387

Faecal microbiota transplantation for Clostridioides difficile: mechanisms and pharmacology.
Khoruts A, Staley C, Sadowsky MJ.
Nat Rev Gastroenterol Hepatol. 2021 Jan;18(1):67-80. doi: 10.1038/s41575-020-0350-4.
PMID: 32843743

T Cell Memory: Understanding COVID-19.
Jarjour NN, Masopust D, Jameson SC.
Immunity. 2021 Jan 12;54(1):14-18. doi: 10.1016/j.immuni.2020.12.009. Epub 2020 Dec 19.
PMID: 33406391

The Naming of Memory T-Cell Subsets.
Jameson SC.
Cold Spring Harb Perspect Biol. 2021 Jan 4;13(1):a037788. doi: 10.1101/cshperspect.a037788.
PMID: 33229439

2020 publications

2019 publications

2018 publications

2017 publications