The Center for Immunology produces an immense amount of research each year.  The data produced is comprehensive and timely to research across the globe.  Our research is supported by Government, Commercial and Industrial grants and private funds and is produced in our state of the art research facilities.  The research is carried out by faculty members, visiting scholars, post-doctoral fellows, graduate and undergraduate students and technicians. The Center for Immunology also has a strong collaboration history with colleagues at other Universities and research companies worldwide.


 To honor Center for Immunology faculty with 200 or more citations on one paper we have created our wall of honor. 


View the Wall of Honor


2017 publications

STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development.
Brady NJ, Farrar MA, Schwertfeger KL.
Dev Biol. 2017 Aug 1;428(1):232-244. doi: 10.1016/j.ydbio.2017.06.007. Epub 2017 Jun 9
PMID: 28606561

Immunologic response to vaccine challenge in pregnant PTPN22 R620W carriers and non-carriers.
Tien SH, Crabtree JN, Gray HL, Peterson EJ.
PLoS One. 2017 Jul 19;12(7):e0181338. doi: 10.1371/journal.pone.0181338. eCollection 2017.
PMID: 28723925 

Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen.
Leonard JD, Gilmore DC, Dileepan T, Nawrocka WI, Chao JL, Schoenbach MH, Jenkins MK, Adams EJ, Savage PA.
Immunity. 2017 Jul 18;47(1):107-117.e8. doi: 10.1016/j.immuni.2017.06.015. Epub 2017 Jul 11.
PMID: 28709804

Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology.
Masopust D, Sivula CP, Jameson SC.
J Immunol. 2017 Jul 15;199(2):383-388. doi: 10.4049/jimmunol.1700453. Review.
PMID: 28696328

Tissue-resident memory T cells live off the fat of the land.
Stolley JM, Masopust D.
Cell Res2017 Jul;27(7):847-848. doi: 10.1038/cr.2017.49. Epub 2017 Mar 31
PMID: 28361896

CD8αα intraepithelial lymphocytes arise from two main thymic precursors.
Ruscher R, Kummer RL, Lee YJ, Jameson SC, Hogquist KA.
Nat Immunol2017 Jul;18(7):771-779. doi: 10.1038/ni.3751. Epub 2017 May 22.
PMID: 28530714

Cytokine-mediated activation of human ex vivo-expanded Vγ9Vδ2 T cells.
Domae E, Hirai Y, Ikeo T, Goda S, Shimizu Y.
Oncotarget. 2017 Jul 11;8(28):45928-45942. doi: 10.18632/oncotarget.17498.

Sleeve Gastrectomy Drives Persistent Shifts in the Gut Microbiome.
Jahansouz C, Staley C, Bernlohr DA, Sadowsky MJ, Khoruts A, Ikramuddin S.
Surg Obes Relat Dis2017 Jun;13(6):916-924. doi: 10.1016/j.soard.2017.01.003. Epub 2017 Jan 4.
PMID: 28279578

Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.
Katerndahl CD, Heltemes-Harris LM, Willette MJ, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KA, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Müschen M, Kornblau SM, Farrar MA.
Nat Immunol. 2017 Jun;18(6):694-704. doi: 10.1038/ni.3716. Epub 2017 Apr 3.
PMID: 28369050

Successful Resolution of Recurrent Clostridium difficile Infection using Freeze-Dried, Encapsulated Fecal Microbiota; Pragmatic Cohort Study.
Staley C, Hamilton MJ, Vaughn BP, Graiziger CT, Newman KM, Kabage AJ, Sadowsky MJ, Khoruts A.
Am J Gastroenterol. 2017 Jun;112(6):940-947. doi: 10.1038/ajg.2017.6. Epub 2017 Feb 14.
PMID: 28195180

Cutting Edge: Dual TCRα Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation.
Schuldt NJ, Auger JL, Spanier JA, Martinov T, Breed ER, Fife BT, Hogquist KA, Binstadt BA.
J Immunol. 2017 May 24. pii: 1700406. doi: 10.4049/jimmunol.1700406. [Epub ahead of print]
PMID: 28539428

Implications of Resident Memory T Cells for Transplantation.
Beura LK, Rosato PC, Masopust D.
Am J Transplant. 2017 May;17(5):1167-1175. doi: 10.1111/ajt.14101. Epub 2016 Dec 9. Review.
PMID: 27804207

Role of bone marrow-derived CD11c+ dendritic cells in systolic overload-induced left ventricular inflammation, fibrosis and hypertrophy.
Wang H, Kwak D, Fassett J, Liu X, Yao W, Weng X, Xu X, Xu Y, Bache RJ, Mueller DL, Chen Y.
Basic Res Cardiol. 2017 May;112(3):25. doi: 10.1007/s00395-017-0615-4. Epub 2017 Mar 27.
PMID: 28349258

Analysis of gut microbiota - An ever changing landscape.
Sadowsky MJ, Staley C, Heiner C, Hall R, Kelly CR, Brandt L, Khoruts A.
Gut Microbes. 2017 May 4;8(3):268-275. doi: 10.1080/19490976.2016.1277313. Epub 2017 Jan 4.
PMID: 28051919

Fecal Microbiota Transplantation - Early Steps on a Long Journey Ahead.
Khoruts A.
Gut Microbes. 2017 May 4;8(3):199-204. doi: 10.1080/19490976.2017.1316447. Epub 2017 Apr 10. No abstract available.
PMID: 28394706

Treatment of recurrent Clostridium difficile infection using fecal microbiota transplantation in patients with inflammatory bowel disease.
Newman KM, Rank KM, Vaughn BP, Khoruts A.
Gut Microbes. 2017 May 4;8(3):303-309. doi: 10.1080/19490976.2017.1279377. Epub 2017 Jan 19.
PMID: 28102756

Role of bone marrow-derived CD11c+ dendritic cells in systolic overload-induced left ventricular inflammation, fibrosis and hypertrophy.
Wang H, Kwak D, Fassett J, Liu X, Yao W, Weng X, Xu X, Xu Y, Bache RJ, Mueller DL, Chen Y.
Basic Res Cardiol. 2017 May;112(3):25. doi: 10.1007/s00395-017-0615-4. Epub 2017 Mar 27.
PMID: 28349258

Synthesis and Biological Evaluation of Bile Acid Analogues Inhibitory to Clostridium difficile Spore Germination.
Stoltz KL, Erickson R, Staley C, Weingarden AR, Romens E, Steer CJ, Khoruts A, Sadowsky MJ, Dosa PI.
J Med Chem. 2017 Apr 27;60(8):3451-3471. doi: 10.1021/acs.jmedchem.7b00295. Epub 2017 Apr 12.
PMID: 28402634

Antigen-Presenting Cells in the Skin.
Kashem SW, Haniffa M, Kaplan DH.
Annu Rev Immunol. 2017 Apr 26;35:469-499. doi: 10.1146/annurev-immunol-051116-052215. Epub 2017 Feb 6.
PMID: 28226228

Relationship between CD4 Regulatory T Cells and Anergy In Vivo.
Kalekar LA, Mueller DL.
J Immunol. 2017 Apr 1;198(7):2527-2533. doi: 10.4049/jimmunol.1602031. Review.
PMID: 28320913

What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans? Reevaluating the Potential of Mouse Models for the Human Immune System.
Jameson SC, Masopust D.
Cold Spring Harb Perspect Biol. 2017 Mar 27. pii: a029132. doi: 10.1101/cshperspect.a029132. [Epub ahead of print]
PMID: 28348039

Do Memory B Cells Form Secondary Germinal Centers? It Depends.
Pape KA, Jenkins MK.
Cold Spring Harb Perspect Biol. 2017 Mar 20. pii: a029116. doi: 10.1101/cshperspect.a029116. [Epub ahead of print]
PMID: 28320756

Tissue resident memory T cells and viral immunity.
Rosato PC, Beura LK, Masopust D.
Curr Opin Virol. 2017 Feb;22:44-50. doi: 10.1016/j.coviro.2016.11.011. Epub 2016 Dec 14. Review.
PMID: 27987416

Different Lymphocyte Populations Direct Dichotomous Eosinophil or Neutrophil Responses to Pulmonary Cryptococcus Infection.
Wiesner DL, Smith KD, Kashem SW, Bohjanen PR, Nielsen K.
J Immunol. 2017 Feb 15;198(4):1627-1637. doi: 10.4049/jimmunol.1600821. 
PMID: 28069805

Repeated hapten exposure induces persistent tactile sensitivity in mice modeling localized provoked vulvodynia.
Landry J, Martinov T, Mengistu H, Dhanwada J, Benck CJ, Kline J, Boo B, Swanson L, Tonc E, Daughters R, Fife BT, Chatterjea D.
PLoS One. 2017 Feb 3;12(2):e0169672. doi: 10.1371/journal.pone.0169672.
PMID: 28158195

Gut-sparing treatment of urinary tract infection in patients at high risk of Clostridium difficile infection.
Staley C, Vaughn BP, Graiziger CT, Sadowsky MJ, Khoruts A.
J Antimicrob Chemother2017 Feb;72(2):522-528. doi: 10.1093/jac/dkw499. 
PMID: 27999027

Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study.
Kang DW, Adams JB, Gregory AC, Borody T, Chittick L, Fasano A, Khoruts A, Geis E, Maldonado J, McDonough-Means S, Pollard EL, Roux S, Sadowsky MJ, Lipson KS, Sullivan MB, Caporaso JG, Krajmalnik-Brown R.
Microbiome. 2017 Jan 23;5(1):10. doi: 10.1186/s40168-016-0225-7.
PMID: 28122648

Cutting Edge: Adenosine A2a Receptor Signals Inhibit Germinal Center T Follicular Helper Cell Differentiation during the Primary Response to Vaccination.
Schmiel SE, Yang JA, Jenkins MK, Mueller DL.
J Immunol. 2017 Jan 15;198(2):623-628. doi: 10.4049/jimmunol.1601686.
PMID: 27986907

STAT5 and CD4 + T Cell Immunity.
Owen DL, Farrar MA.
F1000Res. 2017 Jan 11;6:32. doi: 10.12688/f1000research.9838.1. Review.

Identification of MHC-Bound Peptides from Dendritic Cells Infected with Salmonella enterica Strain SL1344: Implications for a Nontyphoidal Salmonella Vaccine.
Karunakaran KP, Yu H, Jiang X, Chan Q, Goldberg MF, Jenkins MK, Foster LJ, Brunham RC.
J Proteome Res. 2017 Jan 6;16(1):298-306. doi: 10.1021/acs.jproteome.6b00926.
PMID: 27802388

Toward revision of antimicrobial therapies in hematopoietic stem cell transplantation: target the pathogens, but protect the indigenous microbiota.
Khoruts A, Hippen KL, Lemire AM, Holtan SG, Knights D, Young JH.
Transl Res. 2017 Jan;179:116-125. doi: 10.1016/j.trsl.2016.07.013. Review.
PMID: 27513211

Interaction of gut microbiota with bile acid metabolism and its influence on disease states.
Staley C, Weingarden AR, Khoruts A, Sadowsky MJ.
Appl Microbiol Biotechnol. 2017 Jan;101(1):47-64. doi: 10.1007/s00253-016-8006-6. Review.
PMID: 27888332

Gene Expression Profiling in Blood and Affected Muscle Tissues Reveals Differential Activation Pathways in Patients with New-onset Juvenile and Adult Dermatomyositis.
López De Padilla CM, Crowson CS, Hein MS, Pendegraft RS, Strausbauch MA, Niewold TB, Ernste FC, Peterson E, Baechler EC, Reed AM.
J Rheumatol. 2017 Jan;44(1):117-124. doi: 10.3899/jrheum.160293.
PMID: 27803134