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The Center for Immunology is an interdisciplinary research program at the University of Minnesota devoted to advancing the field of immunology and educating future immunologists.

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aaiRegister now for the AAI 2016 Advanced Course in Immunology.  This intensive course features several leading experts including our own Steve Jameson presenting recent advances in understanding the biology of the immune system and its role in health and disease.  Deadline to register is July 6, 2016. View the course schedule.
 
 
mike


 

Mike Farrar is the new Virginia and David Utz Land Grant Chair in Fundamental Immunology effective July 1.  This chair was recently held by Matt Mescher who retired in 2015 and was endowed to aid in the recruitment and retention of outstanding faculty in the field of immunobiology in LMP and the Medical School.  Congratulations Mike!!  

 

 
 
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In the April 20, 2016 issue of Nature, the Masopust and Jameson labs show evidence of how laboratory rodents can skew immunology research but that "dirty mice" can clean up the results.  The paper titled: "Normalizing the environment recapitulates adult human immune traits in laboratory mice", shows that once laboratory animals are housed with pet store animals their immune systems become more similar to the human immune system.  More info...
 
 
 
  • Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns

    In this February 2016 Nature Immunology article, Deepali Malhotra, T. Dileepan, You Jeong Lee, Brian Fife, Kris Hogquist, Marc Jenkins, et.al. explain how tolerance mechanisms identified in eGFp-expressing mouse strains govern tolerance to true self antigens. Read more

  • Tumor specific T cells interacting with B16 Tumor cells& CD11c YFP DCs, courtesy of Brian Fife and Jason Mitchell

    Jason Mitchell and Brian Fife show Tumor specific T cells (red and green) interacting with B16 Tumor cells (blue) and CD11c YFP DCs (yellow)

  • Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.

    In this June 2016 Nature Communications article Justin Spanier, Dmitri Kotov, Marc Jenkins, Brian Fife, et al show that after infection with Listeria monocytogenes expressing 2W and W6 antibody treatment, 2W-specific cells were magnetically enriched from the spleen of C57Bl6 mice. Read More

  • Regulated activation of TGF-b by stromal cells can directly control epithelial residence of cells of the immune system through a novel mechanism of intercellular communication.

    Javed Mohammed, Dave Masopust, Lalit Beura, Emily Thompson and Dan Kaplan, et al, report that UV irradiation promotes Langerhans cell migration through diminished integrin expression and TGF-b activation. Read More

  • Most microbe-specific naïve CD4 + T cells produce memory cells during infection

    In Science, January 2016, Noah Tubo, Marc Jenkins, Brian Fife, et.al. identify TH1, TFH and GC-TFH effector cells in different clonal populations of CD44highLLOp:I-Atetramer-binding cells on d.8 and d.60 after infection . Read More

  • Yoji Shimizu, PhD

    Distinguished University Teaching Professor, Laboratory Medicine and Pathology; Director, Medical Scientist Training Program (MD/PhD); Assistant Dean for Graduate Education

  • Alexander Khoruts, MD

    Associate Professor, Medicine

  • Tanya Freedman, PhD

    Assistant Professor, Pharmacology

  • Announcements

    JOIN OUR FACULTY

    The Department of Microbiology and Immunology at the University of Minnesota Medical School invites applications for a tenure-track Assistant Professor faculty position.

    Assistant Professor position details


    Tea and Talk!! 

    every Monday and Thursday
    2:30 p.m. | 2-163 WMBB


    June 27

    Immunology Journal Club
    Jenkins Lab

    "Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation"

    10:30-11:30 a.m. | 2-115 CCRB


    June 28

    Juliet Crabtree Final Defense
    Peterson Lab

    "The Function PTPN22 and the Autoimmune Risk Variant LypW in Immune Responses to Vaccination"

    12:30-1:30 p.m. | 2-102 CMRR


    June 29

    Immunology Super Group
    Masopust Lab

    1:30-2:30 p.m. | 1-125 CCRB