The Center for Immunology is an interdisciplinary research program at the University of Minnesota devoted to advancing the field of immunology and educating future immunologists.
Autoimmunity • Cancer • Vaccines • Cures
Mike Farrar is the new Virginia and David Utz Land Grant Chair in Fundamental Immunology effective July 1. This chair was recently held by Matt Mescher who retired in 2015 and was endowed to aid in the recruitment and retention of outstanding faculty in the field of immunobiology in LMP and the Medical School. Congratulations Mike!!
Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns
In this February 2016 Nature Immunology article, Deepali Malhotra, T. Dileepan, You Jeong Lee, Brian Fife, Kris Hogquist, Marc Jenkins, et.al. explain how tolerance mechanisms identified in eGFp-expressing mouse strains govern tolerance to true self antigens. Read more
Jason Mitchell and Brian Fife show Tumor specific T cells (red and green) interacting with B16 Tumor cells (blue) and CD11c YFP DCs (yellow)
Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.
In this June 2016 Nature Communications article Justin Spanier, Dmitri Kotov, Marc Jenkins, Brian Fife, et al show that after infection with Listeria monocytogenes expressing 2W and W6 antibody treatment, 2W-specific cells were magnetically enriched from the spleen of C57Bl6 mice. Read More
Regulated activation of TGF-b by stromal cells can directly control epithelial residence of cells of the immune system through a novel mechanism of intercellular communication.
Javed Mohammed, Dave Masopust, Lalit Beura, Emily Thompson and Dan Kaplan, et al, report that UV irradiation promotes Langerhans cell migration through diminished integrin expression and TGF-b activation. Read More
Most microbe-specific naïve CD4 + T cells produce memory cells during infection
In Science, January 2016, Noah Tubo, Marc Jenkins, Brian Fife, et.al. identify TH1, TFH and GC-TFH effector cells in different clonal populations of CD44highLLOp:I-Ab tetramer-binding cells on d.8 and d.60 after infection . Read More
The Department of Microbiology and Immunology at the University of Minnesota Medical School invites applications for a tenure-track Assistant Professor faculty position.
every Monday and Thursday
2:30 p.m. | 2-163 WMBB
Immunology Journal Club
10:30-11:30 a.m. | 2-115 CCRB
Juliet Crabtree Final Defense
"The Function PTPN22 and the Autoimmune Risk Variant LypW in Immune Responses to Vaccination"
12:30-1:30 p.m. | 2-102 CMRR
Immunology Super Group
1:30-2:30 p.m. | 1-125 CCRB