The Center for Immunology is an interdisciplinary research program at the University of Minnesota devoted to advancing the field of immunology and educating future immunologists.

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Dr. Kristin Hogquist to be honored at the 2016 Dean's Distinguished Research Lectureship

In 2013 the annual Dean’s Distinguished Research Lectureship (DDRL) emerged as a premiere event to acknowledge faculty research excellence.  The DDRL honors up to two outstanding faculty members who are selected to share their research stories which detail the state of the science when they entered the field, changes that emerged due to their work, and plans or predictions for the future of medicine and basic science research. This year the reception will be held on Monday, November 7 at the Best Buy Auditorium- Northrop Hall.  The doors open at 4:30 with the program beginning at 5pm and a reception to follow, all faculty, staff, graduate students, residents, fellows, and students are invited to attend.  Space is limited so RSVP to secure your seat.



Congatulations to Dr. David Masopust, new HHMI Faculty Scholar!!

Creative solutions to everyday problems and cutting-edge science has been rewarded as Dr. David Masopust has been named to the inaugural class of Howard Hughes Medical Institute (HHMI) Faculty Scholars.  Read the complete article here




'Dirty' mice model human biology better

In work published in Nature, U researchers Dave Masopust and Steve Jameson have called into question the practice of studying the immune system by using only lab mice that have been protected from exposure to microbes. Getting "dirtied" by pet store mice helped lab mice build immune systems that more closely resembled the human variety. This seminal finding could lead to more realistic research that preserves time, money, and effort in developing vaccines or treatments. Learn more >

This new Science article once again shows that work done by the labs of Drs. Masopust and Jameson is leading more researchers to question the validity of the "clean mouse" model. Read article here

  • Co-housing with pet store mice changes the immune system of laboratory mice

    In this April 20, 2016 issue of Nature, Lalit Beura, Sara Hamilton, Marc Jenkins, Vaiva Vezys, Steve Jameson, Dave Masopust, show evidence of how laboratory rodents can skew immunology research but that "dirty mice" can clean up the results. Read more

  • Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns

    In this February 2016 Nature Immunology article, Deepali Malhotra, T. Dileepan, You Jeong Lee, Brian Fife, Kris Hogquist, Marc Jenkins, explain how tolerance mechanisms identified in eGFp-expressing mouse strains govern tolerance to true self antigens. Read more

  • Tumor specific T cells interacting with B16 Tumor cells& CD11c YFP DCs, courtesy of Brian Fife and Jason Mitchell

    Jason Mitchell and Brian Fife show Tumor specific T cells (red and green) interacting with B16 Tumor cells (blue) and CD11c YFP DCs (yellow)

  • Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.

    In this June 2016 Nature Communications article Justin Spanier, Dmitri Kotov, Marc Jenkins, Brian Fife, et al show that after infection with Listeria monocytogenes expressing 2W and W6 antibody treatment, 2W-specific cells were magnetically enriched from the spleen of C57Bl6 mice. Read More

  • Regulated activation of TGF-b by stromal cells can directly control epithelial residence of cells of the immune system through a novel mechanism of intercellular communication.

    Javed Mohammed, Dave Masopust, Lalit Beura, Emily Thompson and Dan Kaplan, et al, report that UV irradiation promotes Langerhans cell migration through diminished integrin expression and TGF-b activation. Read More

  • Most microbe-specific naïve CD4 + T cells produce memory cells during infection

    In Science, January 2016, Noah Tubo, Marc Jenkins, Brian Fife, identify TH1, TFH and GC-TFH effector cells in different clonal populations of CD44highLLOp:I-Atetramer-binding cells on d.8 and d.60 after infection . Read More

  • Sara Hamilton, PhD

    Assistant Professor, Department of Lab, Med and Pathology

  • Matthew Mescher, PhD

    Professor Emeritus

  • Harry Orr, PhD

    Professor, Laboratory Medicine and Pathology

  • Announcements

    Tea and Talk!!

    every Monday and Thursday
    2:30 p.m. | 2-163 WMBB

    October 24

    Immunology Journal Club
    Shirdi Schmiel-Mueller Lab

    "TFH cells progressively differentiate to regulate the germinal center response"

    10:30-11:30 a.m. | 2-115 CCRB

    October 26

    Immunology Super Group
    Vezys Lab

    1:30-2:30 p.m. | 1-125 CCRB

    October 31

    Immunology Journal Club

    10:30-11:30 a.m. | 2-115 CCRB

    November 2

    Immunology Super Group
    Fife Lab

    1:30-2:30 p.m. | 1-125 CCRB


    Research ethics at the University of Minnesota

    We are committed to protecting research participants, upholding ethical standards, and improving our practice at every step of our work.

    Learn more about our commitment to research ethics