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The Center for Immunology is an interdisciplinary research program at the University of Minnesota devoted to advancing the field of immunology and educating future immunologists.

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Latest News

Congratulations to Dr. Alexander Khoruts and Dr. Vaiva Vezys on your recent promotions announced at the 2016 Medical School Promotion and Tenure Excellence Reception on June 16, 2016.  Learn more

 

alex

 

The July 15, 2016 issue of The New York Times features work being done by Dr. Alexander Khoruts, Medical Director of the University of Minnesota Microbiota Therapeutics Program and CFI member. The article talks about the use of fecal transplants, and how the procedure has proved remarkably effective against potentially fatal infections of bacteria known as Clostridium difficile

 

 

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'Dirty' mice model human biology better

In work published in Nature, U researchers Dave Masopust and Steve Jameson have called into question the practice of studying the immune system by using only lab mice that have been protected from exposure to microbes. Getting "dirtied" by pet store mice helped lab mice build immune systems that more closely resembled the human variety. This seminal finding could lead to more realistic research that preserves time, money, and effort in developing vaccines or treatments. Learn more >

This new Science article once again shows that work done by the labs of Drs. Masopust and Jameson is leading more researchers to question the validity of the "clean mouse" model. Read article here

 
 

 shirdi 

MICaB PhD student Shirdi Schmiel won 2nd place for her presentation: "Adenosine: Targeting the Enemy From Within" made at the 3 Minute Thesis Competition during the 9th annual Biomedical Sciences Graduate Programs Research Recognition Day on May 26, 2016. Congratulations to Shirdi and to all the winners!!

 
 
 
 
  • Co-housing with pet store mice changes the immune system of laboratory mice

    In this April 20, 2016 issue of Nature, Lalit Beura, Sara Hamilton, Marc Jenkins, Vaiva Vezys, Steve Jameson, Dave Masopust, et.al. show evidence of how laboratory rodents can skew immunology research but that "dirty mice" can clean up the results. Read more

  • Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns

    In this February 2016 Nature Immunology article, Deepali Malhotra, T. Dileepan, You Jeong Lee, Brian Fife, Kris Hogquist, Marc Jenkins, et.al. explain how tolerance mechanisms identified in eGFp-expressing mouse strains govern tolerance to true self antigens. Read more

  • Tumor specific T cells interacting with B16 Tumor cells& CD11c YFP DCs, courtesy of Brian Fife and Jason Mitchell

    Jason Mitchell and Brian Fife show Tumor specific T cells (red and green) interacting with B16 Tumor cells (blue) and CD11c YFP DCs (yellow)

  • Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.

    In this June 2016 Nature Communications article Justin Spanier, Dmitri Kotov, Marc Jenkins, Brian Fife, et al show that after infection with Listeria monocytogenes expressing 2W and W6 antibody treatment, 2W-specific cells were magnetically enriched from the spleen of C57Bl6 mice. Read More

  • Regulated activation of TGF-b by stromal cells can directly control epithelial residence of cells of the immune system through a novel mechanism of intercellular communication.

    Javed Mohammed, Dave Masopust, Lalit Beura, Emily Thompson and Dan Kaplan, et al, report that UV irradiation promotes Langerhans cell migration through diminished integrin expression and TGF-b activation. Read More

  • Most microbe-specific naïve CD4 + T cells produce memory cells during infection

    In Science, January 2016, Noah Tubo, Marc Jenkins, Brian Fife, et.al. identify TH1, TFH and GC-TFH effector cells in different clonal populations of CD44highLLOp:I-Atetramer-binding cells on d.8 and d.60 after infection . Read More

  • Brian Fife, PhD

    Assistant Professor, Medicine

  • Bryce Binstadt, MD, PhD

    Associate Professor, Pediatrics

  • Sara Hamilton, PhD

    Assistant Professor, Department of Lab, Med and Pathology

  • Announcements


    Tea and Talk!!

    every Monday and Thursday
    2:30 p.m. | 2-163 WMBB


    August 29

    Immunology Journal Club
    Oscar Salgado Barrero-Hogquist Lab

    "Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83".

    10:30-11:30 a.m. | 2-115 CCRB


    August 31

    Immunology Special Super Group
    Tim Niewold

    1:30-2:30 p.m. | 1-125 CCRB


    September 5

    Immunology Journal Club
    HOLIDAY!!

    10:30-11:30 a.m. | 2-115 CCRB


    September 7

    Immunology Super Group
    Shimizu Lab

    1:30-2:30 p.m. | 1-125 CCRB


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    We are committed to protecting research participants, upholding ethical standards, and improving our practice at every step of our work.

    Learn more about our commitment to research ethics