2020 Publications

2020 publications

Inducing Experimental Polymicrobial Sepsis by Cecal Ligation and Puncture.
Sjaastad FV, Jensen IJ, Berton RR, Badovinac VP, Griffith TS.
Curr Protoc Immunol. 2020 Dec;131(1):e110. doi: 10.1002/cpim.110.
PMID: 33027848

Single Cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium
Jessica K. FiegeJoshua M. ThiedeHezkiel NandaWilliam E MatchettPatrick J. MooreNoe Rico MontanariBeth K ThielenJerry DanielEmma StanleyRyan C Hunter, Vineet D MenacherySteven S. ShenTyler D. BoldRyan A. Langlois

Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid.
Brouwers H, Jónasdóttir HS, Kuipers ME, Kwekkeboom JC, Auger JL, Gonzalez-Torres M, López-Vicario C, Clària J, Freysdottir J, Hardardottir I, Garrido-Mesa J, Norling LV, Perretti M, Huizinga TWJ, Kloppenburg M, Toes REM, Binstadt B, Giera M, Ioan-Facsinay A.
J Immunol. 2020 Oct 2:ji1801653. doi: 10.4049/jimmunol.1801653. Online ahead of print.
PMID: 33008950

Cerebrospinal fluid bacillary load by Xpert MTB/RIF Ultra PCR Cycle Threshold value predicts two-week mortality in HIV-associated tuberculous meningitis.
Martyn EM, Bangdiwala AS, Kagimu E, Rutakingirwa MK, Kasibante J, Okirwoth M, Stead G, Wadda V, Pullen MF, Bold TD, Meya DB, Boulware DR, Bahr NC, Cresswell FV.
Clin Infect Dis. 2020 Sep 28:ciaa1444. doi: 10.1093/cid/ciaa1444. Online ahead of print.
PMID: 32986792

Diverse Macrophage Populations Contribute to the Inflammatory Microenvironment in Premalignant Lesions During Localized Invasion.
Ibrahim AM, Moss MA, Gray Z, Rojo MD, Burke CM, Schwertfeger KL, Dos Santos CO, Machado HL.
Front Oncol. 2020 Sep 24;10:569985. doi: 10.3389/fonc.2020.569985. eCollection 2020.
PMID: 33072601

Hybrid Fc-fused interleukin-7 induces an inflamed tumor microenvironment and improves the efficacy of cancer immunotherapy.
Kim JH, Kim YM, Choi D, Jo SB, Park HW, Hong SW, Park S, Kim S, Moon S, You G, Kang YW, Park Y, Lee BH, Lee SW.
Clin Transl Immunology. 2020 Sep 4;9(9):e1168. doi: 10.1002/cti2.1168. eCollection 2020.
PMID: 32994996

Antigen-Specific CD4+ T Cells Exhibit Distinct Kinetic and Phenotypic Patterns During Primary and Secondary Responses to Infection.
Malhotra D, Burrack KS, Jenkins MK, Frosch AE.
Front Immunol. 2020 Sep 2;11:2125. doi: 10.3389/fimmu.2020.02125. eCollection 2020.
PMID: 32983171

SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with non-severe disease.
Gniadek TJ, Thiede JM, Matchett WE, Gress AR, Pape KA, Fiege JK, Jenkins MK, Menachery VD, Langlois RA, Bold TD.
Transfusion. 2020 Sep 16. doi: 10.1111/trf.16101. Online ahead of print.
PMID: 32935872

Immunopharmacology and Quantitative Analysis of Tyrosine Kinase Signaling.
Brian BF 4th, Guerrero CR, Freedman TS.
Curr Protoc Immunol. 2020 Sep;130(1):e104. doi: 10.1002/cpim.104.
PMID: 32931655

The relationship between CD4+ follicular helper T cells and CD8+ resident memory T cells: sisters or distant cousins?
Peng C, Jameson SC.
Int Immunol. 2020 Sep 8;32(9):583-587. doi: 10.1093/intimm/dxaa045.
PMID: 32620009

Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression.
Williams JW, Zaitsev K, Kim KW, Ivanov S, Saunders BT, Schrank PR, Kim K, Elvington A, Kim SH, Tucker CG, Wohltmann M, Fife BT, Epelman S, Artyomov MN, Lavine KJ, Zinselmeyer BH, Choi JH, Randolph GJ.
Nat Immunol. 2020 Sep 7. doi: 10.1038/s41590-020-0768-4. Online ahead of print.
PMID: 32895539

Lessons of COVID-19: A roadmap for post-pandemic science.
Freedman TS, Headley MB, Serwas N, Ruhland M, Castellanos CA, Combes AJ, Krummel MF.
J Exp Med. 2020 Sep 7;217(9):e20201276. doi: 10.1084/jem.20201276.
PMID: 32735669

P2Y11: The CD4 T cell mitochondrial shepherd.
Borges da Silva H.
J Leukoc Biol. 2020 Sep 2. doi: 10.1002/JLB.2CE0620-240R. Online ahead of print.
PMID: 32876961

Isolation of Cancer-Derived Exosomes Using a Variety of Magnetic Nanostructures: From Fe3O4 Nanoparticles to Ni Nanowires.
Nemati Z, Zamani Kouhpanji MR, Zhou F, Das R, Makielski K, Um J, Phan MH, Muela A, Fdez-Gubieda ML, Franklin RR, Stadler BJH, Modiano JF, Alonso J.
Nanomaterials (Basel). 2020 Aug 25;10(9):E1662. doi: 10.3390/nano10091662.
PMID: 32854239

Faecal microbiota transplantation for Clostridioides difficile: mechanisms and pharmacology.
Khoruts A, Staley C, Sadowsky MJ.
Nat Rev Gastroenterol Hepatol. 2020 Aug 25. doi: 10.1038/s41575-020-0350-4. Online ahead of print.
PMID: 32843743

Cell type- and replication stage-specific influenza virus responses in vivo.
Fay EJ, Aron SL, Macchietto MG, Markman MW, Esser-Nobis K, Gale M Jr, Shen S, Langlois RA.
PLoS Pathog. 2020 Aug 13;16(8):e1008760. doi: 10.1371/journal.ppat.1008760. Online ahead of print.
PMID: 32790753

Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity.Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity.
Sjaastad FV, Kucaba TA, Dileepan T, Swanson W, Dail C, Cabrera-Perez J, Murphy KA, Badovinac VP, Griffith TS.
Front Immunol. 2020 Aug 12;11:1786. doi: 10.3389/fimmu.2020.01786. eCollection 2020.
PMID: 32903436

Protein O-GlcNAc Modification Links Dietary and Gut Microbial Cues to the Differentiation of Enteroendocrine L Cells.
Zhao M, Ren K, Xiong X, Cheng M, Zhang Z, Huang Z, Han X, Yang X, Alejandro EU, Ruan HB.
Cell Rep. 2020 Aug 11;32(6):108013. doi: 10.1016/j.celrep.2020.108013.
PMID: 32783937

Novel protein pathways in development and progression of pulmonary sarcoidosis.
Bhargava M, Viken KJ, Barkes B, Griffin TJ, Gillespie M, Jagtap PD, Sajulga R, Peterson EJ, Dincer HE, Li L, Restrepo CI, O'Connor BP, Fingerlin TE, Perlman DM, Maier LA.
Sci Rep. 2020 Aug 6;10(1):13282. doi: 10.1038/s41598-020-69281-8.
PMID: 32764642

Intestinal CD8αα IELs derived from two distinct thymic precursors have staggered ontogeny.
Ruscher R, Lee ST, Salgado OC, Breed ER, Osum SH, Hogquist KA.
J Exp Med. 2020 Aug 3;217(8):e20192336. doi: 10.1084/jem.20192336
PMID: 32687575

Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection.
Stolley JM, Johnston TS, Soerens AG, Beura LK, Rosato PC, Joag V, Wijeyesinghe SP, Langlois RA, Osum KC, Mitchell JS, Masopust D.
J Exp Med. 2020 Aug 3;217(8):e20192197. doi: 10.1084/jem.20192197.
PMID: 32568362

Adoptive T Cell Therapy with IL-12-Preconditioned Low-Avidity T Cells Prevents Exhaustion and Results in Enhanced T Cell Activation, Enhanced Tumor Clearance, and Decreased Risk for Autoimmunity.
Tucker CG, Mitchell JS, Martinov T, Burbach BJ, Beura LK, Wilson JC, Dwyer AJ, Singh LM, Mescher MF, Fife BT.
J Immunol. 2020 Jul 31:ji2000007. doi: 10.4049/jimmunol.2000007. Online ahead of print.
PMID: 32737148

Kinetically distinct processing pathways diversify the CD8+ T cell response to a single viral epitope.
Cosma GL, Lobby JL, Fay EJ, Siciliano NA, Langlois RA, Eisenlohr LC.
Proc Natl Acad Sci U S A. 2020 Jul 27:202004372. doi: 10.1073/pnas.2004372117. Online ahead of print.
PMID: 32719124

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.
Zernecke A, Winkels H, Cochain C, Williams JW, Wolf D, Soehnlein O, Robbins CS, Monaco C, Park I, McNamara CA, Binder CJ, Cybulsky MI, Scipione CA, Hedrick CC, Galkina EV, Kyaw T, Ghosheh Y, Dinh HQ, Ley K.
Circ Res. 2020 Jul 17;127(3):402-426. doi: 10.1161/CIRCRESAHA.120.316903. Epub 2020 Jul 16.
PMID: 32673538

CD4 T Cell Responses and the Sepsis-Induced Immunoparalysis State.
Martin MD, Badovinac VP, Griffith TS.
Front Immunol. 2020 Jul 7;11:1364. doi: 10.3389/fimmu.2020.01364. eCollection 2020.
PMID: 32733454

Chemotherapy brings virtual memory T cells into reality for cancer therapy.
Schmiechen ZC, Burrack AL, Stromnes IM.
Cell Mol Immunol. 2020 Jul 3. doi: 10.1038/s41423-020-0496-6. Online ahead of print.
PMID: 32620786

Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β.
Borges da Silva H, Peng C, Wang H, Wanhainen KM, Ma C, Lopez S, Khoruts A, Zhang N, Jameson SC.
Immunity. 2020 Jul 2:S1074-7613(20)30265-X. doi: 10.1016/j.immuni.2020.06.010. Online ahead of print.
PMID: 32640257

Development of canine PD-1/PD-L1 specific monoclonal antibodies and amplification of canine T cell function.
Choi JW, Withers SS, Chang H, Spanier JA, De La Trinidad VL, Panesar H, Fife BT, Sciammas R, Sparger EE, Moore PF, Kent MS, Rebhun RB, McSorley SJ.
PLoS One. 2020 Jul 2;15(7):e0235518. doi: 10.1371/journal.pone.0235518. eCollection 2020.
PMID: 32614928

KLRG1+ Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory.
Renkema KR, Huggins MA, Borges da Silva H, Knutson TP, Henzler CM, Hamilton SE.
J Immunol. 2020 Jul 1:ji1901512. doi: 10.4049/jimmunol.1901512. Online ahead of print.
PMID: 32611727

New Insights into the Immune System Using Dirty Mice.
Hamilton SE, Badovinac VP, Beura LK, Pierson M, Jameson SC, Masopust D, Griffith TS.
J Immunol. 2020 Jul 1;205(1):3-11. doi: 10.4049/jimmunol.2000171.
PMID: 32571979

Frequency of MicroRNA Response Elements Identifies Pathologically Relevant Signaling Pathways in Triple-Negative Breast Cancer.
Nair AA, Tang X, Thompson KJ, Vedell PT, Kalari KR, Subramanian S.
iScience. 2020 Jun 26;23(6):101249. doi: 10.1016/j.isci.2020.101249. Epub 2020 Jun 6.
PMID: 32629614

Polymer-mediated delivery of vaccines to treat opioid use disorders and to reduce opioid-induced toxicity.
Gradinati V, Baruffaldi F, Abbaraju S, Laudenbach M, Amin R, Gilger B, Velagaleti P, Pravetoni M.
Vaccine. 2020 Jun 19;38(30):4704-4712. doi: 10.1016/j.vaccine.2020.05.027. Epub 2020 May 19.
PMID: 32439214

Probiotics: Promise, Evidence, and Hope.
Khoruts A, Hoffmann DE, Britton RA.
Gastroenterology. 2020 Jun 9:S0016-5085(20)34728-4. doi: 10.1053/j.gastro.2020.05.058. Online ahead of print.
PMID: 32531290

Comparative phenotypes of peripheral blood and spleen cells from cancer patients.
Cole KE, Ly QP, Hollingsworth MA, Cox JL, Stromnes IM, Padussis JC, Foster JM, Vargas LM, Talmadge JE.
Int Immunopharmacol. 2020 Jun 7;85:106655. doi: 10.1016/j.intimp.2020.106655. [Epub ahead of print]
PMID: 32521493

Instructing Memory in CD8+ Thymocytes.
Ashby KM, Hogquist KA.
Trends Immunol. 2020 Jun 6. pii: S1471-4906(20)30121-6. doi: 10.1016/j.it.2020.05.006. [Epub ahead of print]
PMID: 32518054

Different hierarchies of anti-modified protein autoantibody reactivities in rheumatoid arthritis.
Sahlström P, Hansson M, Steen J, Amara K, Titcombe PJ, Forsström B, Stålesen R, Israelsson L, Piccoli L, Lundberg K, Klareskog L, Mueller DL, Catrina AI, Skriner K, Malmström V, Grönwall C.
Arthritis Rheumatol. 2020 Jun 5. doi: 10.1002/art.41385. Online ahead of print
PMID: 32501655

TLR7/8 Agonist-Loaded Nanoparticles Augment NK Cell-Mediated Antibody-Based Cancer Immunotherapy.
Kim H, Khanna V, Kucaba TA, Zhang W, Sehgal D, Ferguson DM, Griffith TS, Panyam J
Mol Pharm. 2020 Jun 1;17(6):2109-2124. doi: 10.1021/acs.molpharmaceut.0c00271. Epub 2020 May 21.
PMID: 32383885

Tissue-resident macrophages promote extracellular matrix homeostasis in the mammary gland stroma of nulliparous mice.
Wang Y, Chaffee TS, LaRue RS, Huggins DN, Witschen PM, Ibrahim AM, Nelson AC, Machado HL, Schwertfeger KL.
Elife. 2020 Jun 1;9:e57438. doi: 10.7554/eLife.57438.
PMID: 32479261

T Cell Receptor Engineered Lymphocytes for Cancer Therapy.
Rollins MR, Spartz EJ, Stromnes IM.
Curr Protoc Immunol. 2020 Jun;129(1):e97. doi: 10.1002/cpim.97.
PMID: 32432843

Probiotics: promise, evidence, and hope.
Khoruts A, Hoffmann DE, Britton RA.
Gastroenterology. 2020 May 25. pii: S0016-5085(20)34728-4. doi: 10.1053/j.gastro.2020.05.058. [Epub ahead of print] No abstract available. 
PMID: 32531290

Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer.
Witschen PM, Chaffee TS, Brady NJ, Huggins DN, Knutson TP, LaRue RS, Munro SA, Tiegs L, McCarthy JB, Nelson AC, Schwertfeger KL.
Cancers (Basel). 2020 May 22;12(5):E1325. doi: 10.3390/cancers12051325.
PMID: 32455980

The Immune Landscape of Visceral Adipose Tissue During Obesity and Aging.
Khan S, Chan YT, Revelo XS, Winer DA.
Front Endocrinol (Lausanne). 2020 May 15;11:267. doi: 10.3389/fendo.2020.00267. eCollection 2020.
PMID: 32499756

Polymer-mediated delivery of vaccines to treat opioid use disorders and to reduce opioid-induced toxicity.
Gradinati V, Baruffaldi F, Abbaraju S, Laudenbach M, Amin R, Gilger B, Velagaleti P, Pravetoni M.
Vaccine. 2020 May 19:S0264-410X(20)30646-0. doi: 10.1016/j.vaccine.2020.05.027. Online ahead of print.
PMID: 32439214

T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers.
Arunachalam PS, Charles TP, Joag V, Bollimpelli VS, Scott MKD, Wimmers F, Burton SL, Labranche CC, Petitdemange C, Gangadhara S, Styles TM, Quarnstrom CF, Walter KA, Ketas TJ, Legere T, Jagadeesh Reddy PB, Kasturi SP, Tsai A, Yeung BZ, Gupta S, Tomai M, Vasilakos J, Shaw GM, Kang CY, Moore JP, Subramaniam S, Khatri P, Montefiori D, Kozlowski PA, Derdeyn CA, Hunter E, Masopust D, Amara RR, Pulendran B.
Nat Med. 2020 May 11. doi: 10.1038/s41591-020-0858-8. Online ahead of print.
PMID: 32393800

Acquired Resistance to Immune Checkpoint Blockade Therapies.
Zhao X, Wangmo D, Robertson M, Subramanian S.
Cancers (Basel). 2020 May 5;12(5):E1161. doi: 10.3390/cancers12051161.
PMID: 32380703

CD8+ T cells mediate ultraviolet A-induced immunomodulation in a model of extracorporeal photochemotherapy.
Hequet O, Nosbaum A, Guironnet-Paquet A, Blasco E, Nicolas-Virelizier E, Griffith TS, Rigal D, Cognasse F, Nicolas JF, Vocanson M.
Eur J Immunol. 2020 May;50(5):725-735. doi: 10.1002/eji.201948318. Epub 2020 Feb 10.
PMID: 32012249

Antigen discovery unveils resident memory and migratory cell roles in antifungal resistance.
Dobson HE, Dias LDS, Kohn EM, Fites S, Wiesner DL, Dileepan T, Kujoth GC, Abraham A, Ostroff GR, Klein BS, Wüthrich M.
Mucosal Immunol. 2020 May;13(3):518-529. doi: 10.1038/s41385-019-0244-3. Epub 2020 Jan 3.
PMID: 31900406

Single Cell RNA Sequencing in Atherosclerosis Research.
Williams JW, Winkels H, Durant CP, Zaitsev K, Ghosheh Y, Ley K.
Circ Res. 2020 Apr 24;126(9):1112-1126. doi: 10.1161/CIRCRESAHA.119.315940. Epub 2020 Apr 23.
PMID: 32324494

NCOR1 Orchestrates Transcriptional Landscapes and Effector Functions of CD4+ T Cells.
Hainberger D, Stolz V, Zhu C, Schuster M, Müller L, Hamminger P, Rica R, Waltenberger D, Alteneder M, Krausgruber T, Hladik A, Knapp S, Bock C, Trauner M, Farrar MA, Ellmeier W. 
Front Immunol. 2020 Apr 3;11:579. doi: 10.3389/fimmu.2020.00579. eCollection 2020.
PMID: 32318068

Is the opioid use disorder epidemic impacting our immunological health?
Pravetoni M.
Brain Behav Immun. 2020 Apr 10. pii: S0889-1591(20)30487-6. doi: 10.1016/j.bbi.2020.04.022. [Epub ahead of print] No abstract available. 
PMID: 32283290

Exploiting antibody biology for the treatment of cancer.
Khanna V, Panyam J, Griffith TS.
Immunotherapy. 2020 Mar 24. doi: 10.2217/imt-2019-0118. [Epub ahead of print]
PMID:  32208784

Evolutionarily conserved resistance to phagocytosis observed in melanoma cells is insensitive to upregulation of pro-phagocytic signals and to CD47 blockade.
Anderson KL, Snyder KM, Ito D, Lins DC, Mills LJ, Weiskopf K, Ring NG, Ring AM, Shimizu Y, Mescher MF, Weissman IL, Modiano JF.
Melanoma Res. 2020 Apr;30(2):147-158. doi: 10.1097/CMR.0000000000000629.
PMID:  31205227

Gut dysbiosis during antileukemia chemotherapy versus allogeneic hematopoietic cell transplantation.
Rashidi A, Kaiser T, Graiziger C, Holtan SG, Rehman TU, Weisdorf DJ, Dunny GM, Khoruts A, Staley C.
Cancer. 2020 Apr 1;126(7):1434-1447. doi: 10.1002/cncr.32641. Epub 2019 Dec 24.
PMID:  31873965

Developmental plasticity allows outside-in immune responses by resident memory T cells.
Fonseca R, Beura LK, Quarnstrom CF, Ghoneim HE, Fan Y, Zebley CC, Scott MC, Fares-Frederickson NJ, Wijeyesinghe S, Thompson EA, Borges da Silva H, Vezys V, Youngblood B, Masopust D
Nat Immunol. 2020 Apr;21(4):412-421. doi: 10.1038/s41590-020-0607-7. Epub 2020 Feb 17.
PMID:32066954

Neutrophils Recirculate through Lymph Nodes to Survey Tissues for Pathogens.
Bogoslowski A, Wijeyesinghe S, Lee WY, Chen CS, Alanani S, Jenne C, Steeber DA, Scheiermann C, Butcher EC, Masopust D, Kubes P.
J Immunol. 2020 Mar 23. pii: ji2000022. doi: 10.4049/jimmunol.2000022. [Epub ahead of print]
PMID:  32205425

Impact of Repeated Cycles of EGF Bispecific Angiotoxin (eBAT) Administered at a Reduced Interval from Doxorubicin Chemotherapy in Dogs with Splenic Hemangiosarcoma.
Borgatti A, Fieberg A, Winter AL, Stuebner K, Taras E, Todhunter D, Masyr A, Rendhal A, Vallera DA, Koopmeiners JS, Modiano JF.
Vet Comp Oncol. 2020 Mar 18. doi: 10.1111/vco.12590. [Epub ahead of print]
PMID:  32187827

Recent advances in iNKT cell development.
Hogquist K, Georgiev H.
F1000Res. 2020 Feb 20;9. pii: F1000 Faculty Rev-127. doi: 10.12688/f1000research.21378.1. eCollection 2020. Review.
PMID:  32148771

Blood and tissue biomarker analysis in dogs with osteosarcoma treated with palliative radiation and intra-tumoral autologous natural killer cell transfer.
Judge SJ, Yanagisawa M, Sturgill IR, Bateni SB, Gingrich AA, Foltz JA, Lee DA, Modiano JF, Monjazeb AM, Culp WTN, Rebhun RB, Murphy WJ, Kent MS, Canter RJ.
PLoS One. 2020 Feb 21;15(2):e0224775. doi: 10.1371/journal.pone.0224775. eCollection 2020
PMID:32084139

Interruption of continuous opioid exposure exacerbates drug-evoked adaptations in the mesolimbic dopamine system.
Lefevre EM, Pisansky MT, Toddes C, Baruffaldi F, Pravetoni M, Tian L, Kono TJY, Rothwell PE.
Neuropsychopharmacology. 2020 Feb 20. doi: 10.1038/s41386-020-0643-x. [Epub ahead of print]
PMID:32079024

Myocardial B cells are a subset of circulating lymphocytes with delayed transit through the heart.
Adamo L, Rocha-Resende C, Lin CY, Evans S, Williams J, Dun H, Li W, Mpoy C, Andhey PS, Rogers BE, Lavine K, Kreisel D, Artyomov M, Randolph GJ, Mann DL.
JCI Insight. 2020 Feb 13;5(3). pii: 134700. doi: 10.1172/jci.insight.134700.
PMID: 31945014

PD-1+ stemlike CD8 T cells are resident in lymphoid tissues during persistent LCMV infection.
Im SJ, Konieczny BT, Hudson WH, Masopust D, Ahmed R.
Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4292-4299. doi: 10.1073/pnas.1917298117.
PMID: 32034098

Integrating resident memory into T cell differentiation models.
Rosato PC, Wijeyesinghe S, Stolley JM, Masopust D.
Curr Opin Immunol. 2020 Feb 1;63:35-42. doi: 10.1016/j.coi.2020.01.001. [Epub ahead of print] Review.
PMID: 32018169

Interactions between the gut microbiome and host gene regulation in cystic fibrosis.
Dayama G, Priya S, Niccum DE, Khoruts A, Blekhman R.
Genome Med. 2020 Jan 28;12(1):12. doi: 10.1186/s13073-020-0710-2.
PMID: 31992345

VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance.
ElTanbouly MA, Zhao Y, Nowak E, Li J, Schaafsma E, Le Mercier I, Ceeraz S, Lines JL, Peng C, Carriere C, Huang X, Day M, Koehn B, Lee SW, Silva Morales M, Hogquist KA, Jameson SC, Mueller D, Rothstein J, Blazar BR, Cheng C, Noelle RJ.
Science. 2020 Jan 17;367(6475). pii: eaay0524. doi: 10.1126/science.aay0524.
PMID: 31949051

Vitamin D3-mediated resistance to a multiple sclerosis model disease depends on myeloid cell 1,25-dihydroxyvitamin D3 synthesis and correlates with increased CD4+ T cell CTLA-4 expression.
Spanier JA, Nashold FE, Nelson CD, Praska CE, Hayes CE.
J Neuroimmunol. 2020 Jan 15;338:577105. doi: 10.1016/j.jneuroim.2019.577105. Epub 2019 Nov 7.
PMID: 31731231