2019 Publications

2019 publications

Vitamin D3-mediated resistance to a multiple sclerosis model disease depends on myeloid cell 1,25-dihydroxyvitamin D3 synthesis and correlates with increased CD4+ T cell CTLA-4 expression.
Spanier JA, Nashold FE, Nelson CD, Praska CE, Hayes CE.
J Neuroimmunol. 2019 Nov 7;338:577105. doi: 10.1016/j.jneuroim.2019.577105. [Epub ahead of print]
PMID:31731231

Microbiota transplant therapy and autism: lessons for the clinic.
Adams JB, Borody TJ, Kang DW, Khoruts A, Krajmalnik-Brown R, Sadowsky MJ.
Expert Rev Gastroenterol Hepatol. 2019 Oct 30. doi: 10.1080/17474124.2019.1687293. [Epub ahead of print]
PMID:31665947

Demystifying Cancer Immunotherapy for Lay Audiences
Ellis K, Pennell CA.
Front Immunol. 2019 Oct 18;10:2488. doi: 10.3389/fimmu.2019.02488. eCollection 2019.
PMID:31681338

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage.
Wong JB, Hewitt SL, Heltemes-Harris LM, Mandal M, Johnson K, Rajewsky K, Koralov SB, Clark MR, Farrar MA, Skok JA.
Nat Commun. 2019 Oct 18;10(1):4768. doi: 10.1038/s41467-019-12824-z.
PMID: 31628339

Myeloid cells activate iNKT cells to produce IL-4 in the thymic medulla.
Wang H, Breed ER, Lee YJ, Qian LJ, Jameson SC, Hogquist KA.
Proc Natl Acad Sci U S A. 2019 Oct 14. pii: 201910412. doi: 10.1073/pnas.1910412116. [Epub ahead of print]
PMID:  31611396

Regulatory T Cell Development in the Thymus.
Owen DL, Sjaastad LE, Farrar MA.
J Immunol. 2019 Oct 15;203(8):2031-2041. doi: 10.4049/jimmunol.1900662. Review.
PMID:31591259

A wild microbiome improves mouse modeling of the human immune response.
Hamilton SE, Griffith TS.
Lab Anim (NY). 2019 Oct 7. doi: 10.1038/s41684-019-0421-8. [Epub ahead of print] No abstract available.
PMID: 31591550

Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node.
Simon T, Li L, Wagner C, Zhang T, Saxena V, Brinkman CC, Tostanoski LH, Ostrand-Rosenberg S, Jewell C, Shea-Donohue T, Hippen K, Blazar B, Abdi R, Bromberg JS.
Transplantation. 2019 Oct;103(10):2075-2089. doi: 10.1097/TP.0000000000002774.
PMID:31343575

Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma.
Megquier K, Turner-Maier J, Swofford R, Kim JH, Sarver AL, Wang C, Sakthikumar S, Johnson J, Koltookian M, Lewellen M, Scott MC, Schulte AJ, Borst L, Tonomura N, Alfoldi J, Painter C, Thomas R, Karlsson EK, Breen M, Modiano JF, Elvers I, Lindblad-Toh K.
Mol Cancer Res. 2019 Sep 30. doi: 10.1158/1541-7786.MCR-19-0221. [Epub ahead of print]
PMID:31570656

Rapid Transduction and Expansion of Transduced T Cells with Maintenance of Central Memory Populations.
Pampusch MS, Haran KP, Hart GT, Rakasz EG, Rendahl AK, Berger EA, Connick E, Skinner PJ.
Mol Ther Methods Clin Dev. 2019 Sep 30;16:1-10. doi: 10.1016/j.omtm.2019.09.007. eCollection 2020 Mar 13. [Epub ahead of print]
PMID:31673565 

Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance.
Fiege JK, Stone IA, Dumm RE, Waring BM, Fife BT, Agudo J, Brown BD, Heaton NS, Langlois RA.
PLoS Pathog. 2019 Sep 26;15(9):e1008077. doi: 10.1371/journal.ppat.1008077. [Epub ahead of print]
PMID: 31557273

Contributions of natural killer cells to the immune response against Plasmodium.
Burrack KS, Hart GT, Hamilton SE.
Malar J. 2019 Sep 18;18(1):321. doi: 10.1186/s12936-019-2953-1. Review.
PMID: 31533835

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GvHD.
Koehn BH, Saha A, McDonald-Hyman C, Loschi M, Thangavelu G, Ma L, Zaiken M, Dysthe J, Krepps W, Panthera J, Hippen K, Jameson SC, Miller JS, Cooper MA, Farady CJ, Iwawaki T, Ting JP, Serody JS, Murphy WJ, Hill GR, Murray PJ, Bronte V, Munn DH, Zeiser R, Blazar BR.
Blood. 2019 Sep 18. pii: blood.2019001950. doi: 10.1182/blood.2019001950. [Epub ahead of print]
PMID:31533918

Robust Iterative Stimulation with Self-Antigens Overcomes CD8+ T Cell Tolerance to Self- and Tumor Antigens.
Nelson CE, Thompson EA, Quarnstrom CF, Fraser KA, Seelig DM, Bhela S, Burbach BJ, Masopust D, Vezys V.
Cell Rep. 2019 Sep 17;28(12):3092-3104.e5. doi: 10.1016/j.celrep.2019.08.038.
PMID: 31533033

Deubiquitinase Otub1 negatively regulates IL-15 signaling in CD8 T cells and NK cells.
Huggins MA, Hamilton SE.
Cell Mol Immunol. 2019 Sep 11. doi: 10.1038/s41423-019-0283-4. [Epub ahead of print] No abstract available.
PMID:31511640

Can intestinal microbiota and circulating microbial products contribute to pulmonary arterial hypertension?
Thenappan T, Khoruts A, Chen Y, Weir EK.
Am J Physiol Heart Circ Physiol. 2019 Nov 1;317(5):H1093-H1101. doi: 10.1152/ajpheart.00416.2019. Epub 2019 Sep 6.
 PMID:31490732

NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation.
Clark SE, Burrack KS, Jameson SC, Hamilton SE, Lenz LL.
Front Immunol. 2019 Sep 4;10:2087. doi: 10.3389/fimmu.2019.02087. eCollection 2019.
PMID:31552035

Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis.
Zhang Z, Huang Z, Ong B, Sahu C, Zeng H, Ruan HB.
Haematologica. 2019 Sep;104(9):1731-1743. doi: 10.3324/haematol.2018.205856. Epub 2019 Feb 21.
PMID:30792196

A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation.
Tran TM, Guha R, Portugal S, Skinner J, Ongoiba A, Bhardwaj J, Jones M, Moebius J, Venepally P, Doumbo S, DeRiso EA, Li S, Vijayan K, Anzick SL, Hart GT, O'Connell EM, Doumbo OK, Kaushansky A, Alter G, Felgner PL, Lorenzi H, Kayentao K, Traore B, Kirkness EF, Crompton PD.
Immunity. 2019 Aug 23. pii: S1074-7613(19)30335-8. doi: 10.1016/j.immuni.2019.08.009. [Epub ahead of print]
PMID:31492649

Poly(d,l-lactide-co-glycolide) Nanoparticles as Delivery Platforms for TLR7/8 Agonist-Based Cancer Vaccine.
Kim H, Griffith TS, Panyam J.
J Pharmacol Exp Ther. 2019 Sep;370(3):715-724. doi: 10.1124/jpet.118.254953. Epub 2019 Jan 4.
PMID: 30610006

Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors.
Hassler T, Urmann E, Teschner S, Federle C, Dileepan T, Schober K, Jenkins MK, Busch DH, Hinterberger M, Klein L.
Proc Natl Acad Sci U S A. 2019 Aug 26. pii: 201907615. doi: 10.1073/pnas.1907615116. [Epub ahead of print]
PMID: 31451631

Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma.
Burrack AL, Spartz EJ, Raynor JF, Wang I, Olson M, Stromnes IM.
Cell Rep. 2019 Aug 20;28(8):2140-2155.e6. doi: 10.1016/j.celrep.2019.07.059.
PMID:31433988

Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization.
Huggins MA, Sjaastad FV, Pierson M, Kucaba TA, Swanson W, Staley C, Weingarden AR, Jensen IJ, Danahy DB, Badovinac VP, Jameson SC, Vezys V, Masopust D, Khoruts A, Griffith TS, Hamilton SE.
Cell Rep. 2019 Aug 13;28(7):1729-1743.e5. doi: 10.1016/j.celrep.2019.07.028.
PMID:31412243

Gut-associated IgA+ immune cells regulate obesity-related insulin resistance.
Luck H, Khan S, Kim JH, Copeland JK, Revelo XS, Tsai S, Chakraborty M, Cheng K, Tao Chan Y, Nøhr MK, Clemente-Casares X, Perry MC, Ghazarian M, Lei H, Lin YH, Coburn B, Okrainec A, Jackson T, Poutanen S, Gaisano H, Allard JP, Guttman DS, Conner ME, Winer S, Winer DA.
Nat Commun. 2019 Aug 13;10(1):3650. doi: 10.1038/s41467-019-11370-y.
PMID:31409776

The Impact of TCR Signal Strength on Resident Memory T Cell Formation during Influenza Virus Infection.
Fiege JK, Stone IA, Fay EJ, Markman MW, Wijeyesinghe S, Macchietto MG, Shen S, Masopust D, Langlois RA.
J Immunol. 2019 Aug 15;203(4):936-945. doi: 10.4049/jimmunol.1900093. Epub 2019 Jun 24.
PMID:31235552

The Functional Requirement for CD69 in Establishment of Resident Memory CD8+ T Cells Varies with Tissue Location.
Walsh DA, Borges da Silva H, Beura LK, Peng C, Hamilton SE, Masopust D, Jameson SC.
J Immunol. 2019 Aug 15;203(4):946-955. doi: 10.4049/jimmunol.1900052. Epub 2019 Jun 26.
PMID:31243092

Programmed Death-1 Restrains the Germinal Center in Type 1 Diabetes.
Martinov T, Swanson LA, Breed ER, Tucker CG, Dwyer AJ, Johnson JK, Mitchell JS, Sahli NL, Wilson JC, Singh LM, Hogquist KA, Spanier JA, Fife BT.
J Immunol. 2019 Aug 15;203(4):844-852. doi: 10.4049/jimmunol.1801535. Epub 2019 Jul 19.
PMID:31324724

A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.
Vacchio MS, Ciucci T, Gao Y, Watanabe M, Balmaceno-Criss M, McGinty MT, Huang A, Xiao Q, McConkey C, Zhao Y, Shetty J, Tran B, Pepper M, Vahedi G, Jenkins MK, McGavern DB, Bosselut R.
Immunity. 2019 Aug 13. pii: S1074-7613(19)30293-6. doi: 10.1016/j.immuni.2019.06.023. [Epub ahead of print]
PMID:31422869

Self-Regulation of Memory CD8 T Cell Metabolism through Extracellular ATP Signaling.
Wanhainen KM, Jameson SC, da Silva HB.
Immunometabolism. 2019;1(1). pii: e190009. doi: 10.20900/immunometab20190009. Epub 2019 Jul 23.
PMID:3142846

Engineered adoptive T-cell therapy prolongs survival in a preclinical model of advanced stage ovarian cancer.
Anderson KG, Voillet V, Bates B, Chiu EY, Burnett MG, Garcia NM, Oda SK, Morse CB, Stromnes IM, Drescher CW, Gottardo R, Greenberg PD.
Cancer Immunol Res. 2019 Jul 23. pii: canimm.0258.2019. doi: 10.1158/2326-6066.CIR-19-0258. [Epub ahead of print]
PMID: 31337659

Early childhood education is critical for Treg cells.
Salgado OC, Hogquist KA.
Nat Immunol. 2019 Jul 15. doi: 10.1038/s41590-019-0440-z. [Epub ahead of print] No abstract available.
PMID:31308543

Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells.
Brian BF, Jolicoeur AS, Guerrero CR, Nunez MG, Sychev ZE, Hegre SA, Sætrom P, Habib N, Drake JM, Schwertfeger KL, Freedman TS.
Elife. 2019 Jul 8;8. pii: e46043. doi: 10.7554/eLife.46043. [Epub ahead of print]
PMID:31282857

7-Methylation of Chenodeoxycholic Acid Derivatives Yields a Substantial Increase in TGR5 Receptor Potency.
Nakhi A, McDermott CM, Stoltz KL, John K, Hawkinson JE, Ambrose EA, Khoruts A, Sadowsky MJ, Dosa PI.
J Med Chem. 2019 Jul 3. doi: 10.1021/acs.jmedchem.9b00770. [Epub ahead of print]
PMID: 31268316

Evolutionarily conserved resistance to phagocytosis observed in melanoma cells is insensitive to upregulation of pro-phagocytic signals and to CD47 blockade.
Anderson KL, Snyder KM, Ito D, Lins DC, Mills LJ, Weiskopf K, Ring NG, Ring AM, Shimizu Y, Mescher MF, Weissman IL, Modiano JF.
Melanoma Res. 2019 Jun 12. doi: 10.1097/CMR.0000000000000629. [Epub ahead of print]
PMID: 31205227

Fecal Microbiota Transplant: A Rose by Any Other Name.
Khoruts A, Brandt LJ.
Am J Gastroenterol. 2019 Jun 14. doi: 10.14309/ajg.0000000000000286. [Epub ahead of print] No abstract available.
PMID: 31205129

Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria.
Hart GT, Tran TM, Theorell J, Schlums H, Arora G, Rajagopalan S, Sangala ADJ, Welsh KJ, Traore B, Pierce SK, Crompton PD, Bryceson YT, Long EO.
J Exp Med. 2019 Jun 3;216(6):1280-1290. doi: 10.1084/jem.20181681. Epub 2019 Apr 12.
PMID:30979790

BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors.
Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK.
J Exp Med. 2019 Jun 3;216(6):1450-1464. doi: 10.1084/jem.20182376. Epub 2019 May 3.
PMID: 31053612

Peptide:MHCII Tetramer-Based Cell Enrichment for the Study of Epitope-Specific CD4+ T Cells.
Kotov DI, Jenkins MK.
Curr Protoc Immunol. 2019 Jun;125(1):e75. doi: 10.1002/cpim.75. Epub 2019 Apr 29.
PMID: 31034767

JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors.
Irey EA, Lassiter CM, Brady NJ, Chuntova P, Wang Y, Knutson TP, Henzler C, Chaffee TS, Vogel RI, Nelson AC, Farrar MA, Schwertfeger KL.
Proc Natl Acad Sci U S A. 2019 May 30. pii: 201816410. doi: 10.1073/pnas.1816410116. [Epub ahead of print]
PMID:31147469

Cytomegalovirus evades TRAIL-mediated innate lymphoid cell 1 defenses.
Picarda G, Ghosh R, McDonald B, Verma S, Thiault N, El Morabiti R, Griffith TS, Benedict CA.
J Virol. 2019 May 29. pii: JVI.00617-19. doi: 10.1128/JVI.00617-19. [Epub ahead of print]
PMID:31142671

Development, ontogeny, and maintenance of TCRαβ+ CD8αα IEL.
Ruscher R, Hogquist KA.
Curr Opin Immunol. 2019 May 27;58:83-88. doi: 10.1016/j.coi.2019.04.010. [Epub ahead of print] Review.
PMID:31146182

Risk Factors for Development of Canine and Human Osteosarcoma: A Comparative Review.
Makielski KM, Mills LJ, Sarver AL, Henson MS, Spector LG, Naik S, Modiano JF.
Vet Sci. 2019 May 25;6(2). pii: E48. doi: 10.3390/vetsci6020048. Review.
PMID:31130627 

Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8+ T Cells.
Hirai T, Zenke Y, Yang Y, Bartholin L, Beura LK, Masopust D, Kaplan DH.
Immunity. 2019 May 21;50(5):1249-1261.e5. doi: 10.1016/j.immuni.2019.03.002. Epub 2019 Apr 2.
PMID:30952606

Editorial: Fresh Ideas, Foundational Experiments: Immunology and Diabetes.
Spanier JA, Tse HM, Horwitz MS, Fife BT.
Front Endocrinol (Lausanne). 2019 May 16;10:315. doi: 10.3389/fendo.2019.00315. eCollection 2019. No abstract available.
PMID:31156560

Differential Regulation of T Cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node.
Simon T, Li L, Wagner C, Zhang T, Saxena V, Brinkman CC, Tostanoski LH, Ostrand-Rosenberg S, Jewell C, Shea-Donohue T, Hippen K, Blazar B, Abdi R, Bromberg JS.
Transplantation. 2019 May 7. doi: 10.1097/TP.0000000000002774. [Epub ahead of print]
PMID: 31343575

CD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responses.
Beura LK, Fares-Frederickson NJ, Steinert EM, Scott MC, Thompson EA, Fraser KA, Schenkel JM, Vezys V, Masopust D.
J Exp Med. 2019 May 6;216(5):1214-1229. doi: 10.1084/jem.20181365. Epub 2019 Mar 28
PMID:30923043

Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes.
Dirice E, Kahraman S, De Jesus DF, El Ouaamari A, Basile G, Baker RL, Yigit B, Piehowski PD, Kim MJ, Dwyer AJ, Ng RWS, Schuster C, Vethe H, Martinov T, Ishikawa Y, Teo AKK, Smith RD, Hu J, Haskins K, Serwold T, Qian WJ, Fife BT, Kissler S, Kulkarni RN.
Nat Metab. 2019 May;1(5):509-518. doi: 10.1038/s42255-019-0061-8. Epub 2019 May 6.
PMID:31423480

Tetrahydrocannabinol Reduces Hapten-Driven Mast Cell Accumulation and Persistent Tactile Sensitivity in Mouse Model of Allergen-Provoked Localized Vulvodynia.
Boo B, Kamath R, Arriaga-Gomez E, Landry J, Emanuel E, Joo S, Saldías Montivero M, Martinov T, Fife BT, Chatterjea D.
Int J Mol Sci. 2019 May 1;20(9). pii: E2163. doi: 10.3390/ijms20092163.
PMID:  31052404

TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.
Kotov DI, Mitchell JS, Pengo T, Ruedl C, Way SS, Langlois RA, Fife BT, Jenkins MK.
J Immunol. 2019 May 1;202(9):2535-2545. doi: 10.4049/jimmunol.1801609. Epub 2019 Mar 11.
PMID: 30858199

Dendritic cell NLRC4 regulates influenza A virus-specific CD4 T cell responses through FasL expression.
Hornick EE, Dagvadorj J, Zacharias ZR, Miller AM, Langlois RA, Chen P, Legge KL, Bishop GA, Sutterwala FS, Cassel SL.
J Clin Invest. 2019 Apr 30;130. pii: 124937. doi: 10.1172/JCI124937.
PMID:31038471

Tissue-Resident T Cells and Other Resident Leukocytes.
Masopust D, Soerens AG.
Annu Rev Immunol. 2019 Apr 26;37:521-546. doi: 10.1146/annurev-immunol-042617-053214. Epub 2019 Feb 6.
PMID: 30726153

Differential effects of depleting versus programming tumor-associated macrophages on engineered T cells in pancreatic ductal adenocarcinoma.
Stromnes IM, Burrack AL, Hulbert A, Bonson P, Black C, Brockenbrough JS, Raynor JF, Spartz EJ, Pierce RH, Greenberg PD, Hingorani SR.
Cancer Immunol Res. 2019 Apr 26. pii: canimm.0448.2018. doi: 10.1158/2326-6066.CIR-18-0448. [Epub ahead of print]
PMID: 31028033

Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance.
Martinov T, Fife BT.
Ann N Y Acad Sci. 2019 Apr 26. doi: 10.1111/nyas.14106. [Epub ahead of print] Review.
PMID: 31025378

Measuring Thymic Clonal Deletion at the Population Level.
Breed ER, Watanabe M, Hogquist KA.
J Immunol. 2019 Apr 22. pii: ji1900191. doi: 10.4049/jimmunol.1900191. [Epub ahead of print]
PMID: 31010850

A comparison of risk factors for metastasis at diagnosis in humans and dogs with osteosarcoma.
Diessner BJ, Marko TA, Scott RM, Eckert AL, Stuebner KM, Hohenhaus AE, Selting KA, Largaespada DA, Modiano JF, Spector LG.
Cancer Med. 2019 Apr 21. doi: 10.1002/cam4.2177. [Epub ahead of print]
PMID: 31006987

Dysbiosis patterns during re-induction/salvage versus induction chemotherapy for acute leukemia.
Rashidi A, Kaiser T, Shields-Cutler R, Graiziger C, Holtan SG, Rehman TU, Wasko J, Weisdorf DJ, Dunny G, Khoruts A, Staley C.
Sci Rep. 2019 Apr 15;9(1):6083. doi: 10.1038/s41598-019-42652-6.
PMID: 30988420

Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria.
Hart GT, Tran TM, Theorell J, Schlums H, Arora G, Rajagopalan S, Sangala ADJ, Welsh KJ, Traore B, Pierce SK, Crompton PD, Bryceson YT, Long EO.
J Exp Med. 2019 Apr 12. pii: jem.20181681. doi: 10.1084/jem.20181681. [Epub ahead of print]
PMID: 30979790

ARTC2.2/P2RX7 Signaling during Cell Isolation Distorts Function and Quantification of Tissue-Resident CD8+ T Cell and Invariant NKT Subsets.
Borges da Silva H, Wang H, Qian LJ, Hogquist KA, Jameson SC.
J Immunol. 2019 Apr 1;202(7):2153-2163. doi: 10.4049/jimmunol.1801613. Epub 2019 Feb 18.
PMID: 30777922

Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8+ T Cells.
Hirai T, Zenke Y, Yang Y, Bartholin L, Beura LK, Masopust D, Kaplan DH.
Immunity. 2019 Mar 23. pii: S1074-7613(19)30092-5. doi: 10.1016/j.immuni.2019.03.002. [Epub ahead of print]
PMID: 30952606

Interstitial Migration of CD8αβ T Cells in the Small Intestine Is Dynamic and Is Dictated by Environmental Cues.
Thompson EA, Mitchell JS, Beura LK, Torres DJ, Mrass P, Pierson MJ, Cannon JL, Masopust D, Fife BT, Vezys V.
Cell Rep. 2019 Mar 12;26(11):2859-2867.e4. doi: 10.1016/j.celrep.2019.02.034.
PMID:30865878

Noninvasive ultrasound stimulation of the spleen to treat inflammatory arthritis.
Zachs DP, Offutt SJ, Graham RS, Kim Y, Mueller J, Auger JL, Schuldt NJ, Kaiser CRW, Heiller AP, Dutta R, Guo H, Alford JK, Binstadt BA, Lim HH.
Nat Commun. 2019 Mar 12;10(1):951. doi: 10.1038/s41467-019-08721-0.
PMID:30862842

Combination of Sunitinib and PD-L1 Blockade Enhances Anticancer Efficacy of TLR7/8 Agonist-Based Nanovaccine.
Kim H, Khanna V, Kucaba TA, Zhang W, Ferguson DM, Griffith TS, Panyam J.
Mol Pharm. 2019 Mar 4;16(3):1200-1210. doi: 10.1021/acs.molpharmaceut.8b01165. Epub 2019 Jan 25.
PMID: 30620878

Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques.
Petitdemange C, Kasturi SP, Kozlowski PA, Nabi R, Quarnstrom CF, Reddy PBJ, Derdeyn CA, Spicer LM, Patel P, Legere T, Kovalenkov YO, Labranche CC, Villinger F, Tomai M, Vasilakos J, Haynes B, Kang CY, Gibbs JS, Yewdell JW, Barouch D, Wrammert J, Montefiori D, Hunter E, Amara RR, Masopust D, Pulendran B.
JCI Insight. 2019 Feb 21;4(4). pii: 126047. doi: 10.1172/jci.insight.126047. eCollection 2019 Feb 21.
PMID:30830870

Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function.
Dumm RE, Fiege JK, Waring BM, Kuo CT, Langlois RA, Heaton NS.
Nat Commun. 2019 Feb 15;10(1):779. doi: 10.1038/s41467-019-08617-z.
PMID: 30770807

Reprogramming responsiveness to checkpoint blockade in dysfunctional CD8 T cells.
Nelson CE, Mills LJ, McCurtain JL, Thompson EA, Seelig DM, Bhela S, Quarnstrom CF, Fife BT, Vezys V.
Proc Natl Acad Sci U S A.  2019 Feb 12;116(7):2640-2645. doi: 10.1073/pnas.1810326116. Epub 2019 Jan 24.
PMID: 30679280

Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy.
Rosato PC, Wijeyesinghe S, Stolley JM, Nelson CE, Davis RL, Manlove LS, Pennell CA, Blazar BR, Chen CC, Geller MA, Vezys V, Masopust D.
Nat Commun. 2019 Feb 4;10(1):567. doi: 10.1038/s41467-019-08534-1.
PMID: 30718505

Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma.
Rahrmann EP, Wolf NK, Otto GM, Heltemes-Harris L, Ramsey LB, Shu J, LaRue RS, Linden MA, Rathe SK, Starr TK, Farrar MA, Moriarity BS, Largaespada DA.
Mol Cancer Res. 2019 Feb;17(2):567-582. doi: 10.1158/1541-7786.MCR-18-0582. Epub 2018 Oct 24.
PMID: 30355676

Dual TCR T Cells: Identity Crisis or Multitaskers?
Schuldt NJ, Binstadt BA.
J Immunol. 2019 Feb 1;202(3):637-644. doi: 10.4049/jimmunol.1800904. Review.
PMID: 30670579

A Fentanyl Vaccine Alters Fentanyl Distribution and Protects against Fentanyl-Induced Effects in Mice and Rats.
Raleigh MD, Baruffaldi F, Peterson SJ, Le Naour M, Harmon TM, Vigliaturo JR, Pentel PR, Pravetoni M.
J Pharmacol Exp Ther. 2019 Feb;368(2):282-291. doi: 10.1124/jpet.118.253674. Epub 2018 Nov 8.
PMID: 30409833

Thymic regulatory T cells arise via two distinct developmental programs.
Owen DL, Mahmud SA, Sjaastad LE, Williams JB, Spanier JA, Simeonov DR, Ruscher R, Huang W, Proekt I, Miller CN, Hekim C, Jeschke JC, Aggarwal P, Broeckel U, LaRue RS, Henzler CM, Alegre ML, Anderson MS, August A, Marson A, Zheng Y, Williams CB, Farrar MA.
Nat Immunol. 2019 Feb;20(2):195-205. doi: 10.1038/s41590-018-0289-6. Epub 2019 Jan 14.
PMID: 30643267

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade.
Wang Z, Aguilar EG, Luna JI, Dunai C, Khuat LT, Le CT, Mirsoian A, Minnar CM, Stoffel KM, Sturgill IR, Grossenbacher SK, Withers SS, Rebhun RB, Hartigan-O'Connor DJ, Méndez-Lagares G, Tarantal AF, Isseroff RR, Griffith TS, Schalper KA, Merleev A, Saha A, Maverakis E, Kelly K, Aljumaily R, Ibrahimi S, Mukherjee S, Machiorlatti M, Vesely SK, Longo DL, Blazar BR, Canter RJ, Murphy WJ, Monjazeb AM.
Nat Med. 2019 Jan;25(1):141-151. doi: 10.1038/s41591-018-0221-5. Epub 2018 Nov 12.
PMID: 30420753

Engineering T cell response to cancer antigens by choice of focal therapeutic conditions.
Shao Q, O'Flanagan S, Lam T, Roy P, Pelaez F, Burbach BJ, Azarin SM, Shimizu Y, Bischof JC.
Int J Hyperthermia. 2019 Jan 24:1-9. doi: 10.1080/02656736.2018.1539253. [Epub ahead of print]
PMID: 30676126

The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation.
Liu B, Salgado OC, Singh S, Hippen KL, Maynard JC, Burlingame AL, Ball LE, Blazar BR, Farrar MA, Hogquist KA, Ruan HB.
Nat Commun. 2019 Jan 21;10(1):354. doi: 10.1038/s41467-019-08300-3.
PMID:30664665

Cutting Edge: T Cell-Dependent Plasmablasts Form in the Absence of Single Differentiated CD4+ T Cell Subsets.
Kotov JA, Jenkins MK.
J Immunol. 2019 Jan 15;202(2):401-405. doi: 10.4049/jimmunol.1801349. Epub 2018 Dec 14.
PMID: 30552165

Autoantibodies in the Pathogenesis, Diagnosis, and Prognosis of Juvenile Idiopathic Arthritis.
Mahmud SA, Binstadt BA.
Front Immunol. 2019 Jan 14;9:3168. doi: 10.3389/fimmu.2018.03168. eCollection 2018. Review.
PMID: 30693002

Alum adjuvant is more effective than MF59 at prompting early germinal center formation in response to peptide-protein conjugates and enhancing efficacy of a vaccine against opioid use disorders.
Robinson C, Baehr C, Schmiel SE, Accetturo C, Mueller DL, Pravetoni M.
Hum Vaccin Immunother. 2019 Jan 9. doi: 10.1080/21645515.2018.1558697. [Epub ahead of print]
PMID: 30625019

Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis.
Lloyd KA, Wigerblad G, Sahlström P, Garimella MG, Chemin K, Steen J, Titcombe PJ, Marklein B, Zhou D, Stålesen R, Ossipova E, Lundqvist C, Ekwall O, Rönnelid J, Mueller DL, Karlsson MCI, Kaplan MJ, Skriner K, Klareskog L, Wermeling F, Malmström V, Grönwall C.
Front Immunol. 2019 Jan 4;9:3033. doi: 10.3389/fimmu.2018.03033. eCollection 2018.
PMID:30662440

Fecal Microbiota Transplantation: Current Status in Treatment of GI and Liver Disease.
Vaughn BP, Rank KM, Khoruts A.
Clin Gastroenterol Hepatol. 2019 Jan;17(2):353-361. doi: 10.1016/j.cgh.2018.07.026. Epub 2018 Jul 25. Review.
PMID: 30055267

Chrysalis: A New Method for High-Throughput Histo-Cytometry Analysis of Images and Movies.
Kotov DI, Pengo T, Mitchell JS, Gastinger MJ, Jenkins MK.
J Immunol. 2019 Jan 1;202(1):300-308. doi: 10.4049/jimmunol.1801202. Epub 2018 Dec 3.
PMID: 30510065

Embracing microbial exposure in mouse research.
Huggins MA, Jameson SC, Hamilton SE.
J Leukoc Biol. 2019 Jan;105(1):73-79. doi: 10.1002/JLB.4RI0718-273R. Epub 2018 Sep 27. Review.
PMID: 30260516

Vaccines to treat opioid use disorders and to reduce opioid overdoses.
Baehr C, Pravetoni M.
Neuropsychopharmacology. 2019 Jan;44(1):217-218. doi: 10.1038/s41386-018-0197-3. No abstract available. 
PMID: 30405185