2016 Publications

2016 Publications

Complete Microbiota Engraftment Is Not Essential for Recovery from Recurrent Clostridium difficile Infection following Fecal Microbiota Transplantation.
Staley C, Kelly CR, Brandt LJ, Khoruts A, Sadowsky MJ.
MBio. 2016 Dec 20;7(6). pii: e01965-16. doi: 10.1128/mBio.01965-16.
PMID: 27999162

High-Resolution Analysis of Antibodies to Post-Translational Modifications Using Peptide Nanosensor Microarrays.
Lee JR, Haddon DJ, Gupta N, Price JV, Credo GM, Diep VK, Kim K, Hall DA, Baechler EC, Petri M, Varma M, Utz PJ, Wang SX.
ACS Nano. 2016 Dec 27;10(12):10652-10660. doi: 10.1021/acsnano.6b03786.
PMID: 27636738

Gut-sparing treatment of urinary tract infection in patients at high risk of Clostridium difficile infection.
Staley C, Vaughn BP, Graiziger CT, Sadowsky MJ, Khoruts A.
J Antimicrob Chemother. 2016 Dec 20. pii: dkw499. doi: 10.1093/jac/dkw499. [Epub ahead of print]
PMID: 27999027

Canine cancer immunotherapy studies: linking mouse and human.
Park JS, Withers SS, Modiano JF, Kent MS, Chen M, Luna JI, Culp WTN, Sparger EE, Rebhun RB, Monjazeb AM, Murphy WJ, Canter RJ.
J Immunother Cancer. 2016 Dec 20;4:97. doi: 10.1186/s40425-016-0200-7. eCollection 2016. Review.
PMID: 28031824

Tissue resident memory T cells and viral immunity.
Rosato PC, Beura LK, Masopust D.
Curr Opin Virol. 2016 Dec 14;22:44-50. doi: 10.1016/j.coviro.2016.11.011. [Epub ahead of print] Review.
PMID: 27987416

Cutting Edge: Adenosine A2a Receptor Signals Inhibit Germinal Center T Follicular Helper Cell Differentiation during the Primary Response to Vaccination.
Schmiel SE, Yang JA, Jenkins MK, Mueller DL.
J Immunol. 2016 Dec 16. pii: 1601686. [Epub ahead of print]
PMID: 27986907

Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20.
Weiskopf K, Anderson KL, Ito D, Schnorr PJ, Tomiyasu H, Ring AM, Bloink K, Efe J, Rue S, Lowery D, Barkal A, Prohaska S, McKenna KM, Cornax I, O'Brien TD, O'Sullivan MG, Weissman IL, Modiano JF.
Cancer Immunol Res. 2016 Dec;4(12):1072-1087. Epub 2016 Nov 14.
PMID: 27856424

Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo.
Strother RK, Danahy DB, Kotov DI, Kucaba TA, Zacharias ZR, Griffith TS, Legge KL, Badovinac VP.
J Immunol. 2016 Dec 1;197(11):4301-4311.
PMID: 27798171

Heterotypic mouse models of canine osteosarcoma recapitulate tumor heterogeneity and biological behavior.
Scott MC, Tomiyasu H, Garbe JR, Cornax I, Amaya C, O'Sullivan MG, Subramanian S, Bryan BA, Modiano JF.
Dis Model Mech. 2016 Dec 1;9(12):1435-1444. Epub 2016 Nov 3.
PMID: 27874835

Simian Immunodeficiency Virus-Producing Cells in Follicles Are Partially Suppressed by CD8+ Cells In Vivo.
Li S, Folkvord JM, Rakasz EG, Abdelaal HM, Wagstaff RK, Kovacs KJ, Kim HO, Sawahata R, MaWhinney S, Masopust D, Connick E, Skinner PJ.
J Virol. 2016 Nov 28;90(24):11168-11180.
PMID: 27707919

Interaction of gut microbiota with bile acid metabolism and its influence on disease states.
Staley C, Weingarden AR, Khoruts A, Sadowsky MJ.
Appl Microbiol Biotechnol. 2016 Nov 25. [Epub ahead of print] Review.
PMID: 27888332

Resident memory T cells are a Notch above the rest.
Wijeyesinghe S, Masopust D.
Nat Immunol. 2016 Nov 16;17(12):1337-1338. doi: 10.1038/ni.3617. No abstract available.
PMID: 27849200

Programmed Death-1 Culls Peripheral Accumulation of High-Affinity Autoreactive CD4 T Cells to Protect against Autoimmunity.
Jiang TT, Martinov T, Xin L, Kinder JM, Spanier JA, Fife BT, Way SS.
Cell Rep. 2016 Nov 8;17(7):1783-1794. doi: 10.1016/j.celrep.2016.10.042.
PMID: 27829150

Implications of Resident Memory T Cells for Transplantation.
Beura LK, Rosato PC, Masopust D.
Am J Transplant. 2016 Nov 2. doi: 10.1111/ajt.14101. [Epub ahead of print]
PMID: 27804207

OKT3 and H57-597: From Discovery, to Commercialization, to the Clinic.
Hogquist KA.
J Immunol. 2016 Nov 1;197(9):3429-3430. No abstract available.
PMID: 27824588

Gene Expression Profiling in Blood and Affected Muscle Tissues Reveals Differential Activation Pathways in Patients with New-onset Juvenile and Adult Dermatomyositis.
López De Padilla CM, Crowson CS, Hein MS, Pendegraft RS, Strausbauch MA, Niewold TB, Ernste FC, Peterson E, Baechler EC, Reed AM.
J Rheumatol. 2016 Nov 1. pii: jrheum.160293. [Epub ahead of print]
PMID: 27803134

How MAIT cells get their start
Wang H, Hogquist KA.
Nat Immunol. 2016 Oct 19;17(11):1238-1240. doi: 10.1038/ni.3584. No abstract available.
PMID: 27760106

PD-1 pathway-mediated regulation of islet-specific CD4+ T cell subsets in autoimmune diabetes.
Martinov T, Spanier JA, Pauken KE, Fife BT.
Immunoendocrinology (Houst). 2016;3. pii: e1164.
PMID: 27656680

Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer.
Trott JF, Kim J, Abu Aboud O, Wettersten H, Stewart B, Berryhill G, Uzal F, Hovey RC, Chen CH, Anderson K, Graef A, Sarver AL, Modiano JF, Weiss RH.
Oncotarget. 2016 Oct 11;7(41):66540-66557. doi: 10.18632/oncotarget.11658.
PMID: 27572319

SIV-producing cells in follicles are partially suppressed by CD8+ cells in vivo.
Li S, Folkvord JM, Rakasz EG, Abdelaal HM, Wagstaff RK, Kovacs KJ, Kim HO, Sawahata R, MaWhinney S, Masopust D, Connick E, Skinner PJ.
J Virol. 2016 Oct 5. pii: JVI.01332-16.
PMID: 27707919

Understanding the mechanisms of faecal microbiota transplantation.
Khoruts A, Sadowsky MJ.
Nat Rev Gastroenterol Hepatol. 2016 Sep;13(9):508-16. doi: 10.1038/nrgastro.2016.98. Epub 2016 Jun 22. Review.
PMID: 27329806

Ursodeoxycholic Acid Inhibits Clostridium difficile Spore Germination and Vegetative Growth, and Prevents the Recurrence of Ileal Pouchitis Associated With the Infection.
Weingarden AR, Chen C, Zhang N, Graiziger CT, Dosa PI, Steer CJ, Shaughnessy MK, Johnson JR, Sadowsky MJ, Khoruts A.
J Clin Gastroenterol. 2016 Sep;50(8):624-630.

Gut Microbial Membership Modulates CD4 T Cell Reconstitution and Function after Sepsis.
Cabrera-Perez J, Babcock JC, Dileepan T, Murphy KA, Kucaba TA, Badovinac VP, Griffith TS.
J Immunol. 2016 Sep 1;197(5):1692-8. doi: 10.4049/jimmunol.1600940. Epub 2016 Jul 22.
PMID: 27448587

Lineage-Specific Effector Signatures of Invariant NKT Cells Are Shared amongst γδ T, Innate Lymphoid, and Th Cells.
Lee YJ, Starrett GJ, Lee ST, Yang R, Henzler CM, Jameson SC, Hogquist KA.
J Immunol. 2016 Aug 15;197(4):1460-70. doi: 10.4049/jimmunol.1600643. Epub 2016 Jul 6.
PMID: 27385777

Prospective studies of infectious mononucleosis in University students.
Grimm JM, Schmeling DO, Dunmire SK, Knight JA, Mullan BD, Ed JA, Brundage RC,Hogquist KA, Balfour Jr, HH.
Clinical & Translational Immunology (2016) 5 e94, published online 12 August 2016

Adhesion- and Degranulation-Promoting Adapter Protein Promotes CD8 T Cell Differentiation and Resident Memory Formation and Function during an Acute Infection.
Fiege JK, Beura LK, Burbach BJ, Shimizu Y.
J Immunol. 2016 Sep 15;197(6):2079-89. doi: 10.4049/jimmunol.1501805. Epub 2016 Aug 12.
PMID: 27521337

Toward revision of antimicrobial therapies in hematopoietic stem cell transplantation: target the pathogens, but protect the indigenous microbiota.
Khoruts A, Hippen KL, Lemire AM, Holtan SG, Knights D, Young JH.
Transl Res. 2016 Jul 25. pii: S1931-5244(16)30128-1. doi: 10.1016/j.trsl.2016.07.013. [Epub ahead of print] Review.
PMID: 27513211

CD28/B7 Deficiency Attenuates Systolic Overload-Induced Congestive Heart Failure, Myocardial and Pulmonary Inflammation, and Activated T Cell Accumulation in the Heart and Lungs.
Wang H, Kwak D, Fassett J, Hou L, Xu X, Burbach BJ, Thenappan T, Xu Y, Ge JB, Shimizu Y, Bache RJ, Chen Y.
Hypertension. 2016 Sep;68(3):688-96. doi: 10.1161/HYPERTENSIONAHA.116.07579. Epub 2016 Jul 18.
PMID: 27432861

CD8 T Cell-Independent Antitumor Response and Its Potential for Treatment of Malignant Gliomas.
Murphy KA, Griffith TS.
Cancers (Basel). 2016 Jul 27;8(8). pii: E71. doi: 10.3390/cancers8080071. Review.
PMID: 27472363

Autoimmune variant PTPN22 C1858T is associated with impaired responses to influenza virus vaccination.
Crabtree JN, He W, Guan W, Flage M, Miller MS, Peterson EJ.
J Infect Dis. 2016 Jul 15;214(2):248-57. doi: 10.1093/infdis/jiw126. Epub 2016 Mar 30.
PMID: 27034343

Skin Immunity to Candida albicans.
Kashem SW, Kaplan DH.
Trends Immunol. 2016 Jul;37(7):440-50. doi: 10.1016/j.it.2016.04.007. Epub 2016 May 10. Review.

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia.
Heltemes-Harris LM, Larson JD, Starr TK, Hubbard GK, Sarver AL, Largaespada DA, Farrar MA.
Oncogene. 2016 Jun 30;35(26):3454-64. doi: 10.1038/onc.2015.405. Epub 2015 Oct 26.

Understanding the mechanisms of faecal microbiota transplantation.
Khoruts A, Sadowsky MJ.
Nat Rev Gastroenterol Hepatol. 2016 Jun 22. doi: 10.1038/nrgastro.2016.98. [Epub ahead of print] Review.
PMID: 27329806

IL-4 sensitivity shapes the peripheral CD8+ T cell pool and response to infection.
Renkema KR, Lee JY, Lee YJ, Hamilton SE, Hogquist KA, Jameson SC.
J Exp Med. 2016 Jun 13. pii: jem.20151359. [Epub ahead of print]
PMID: 27298446

Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.
Spanier JA, Frederick DR, Taylor JJ, Heffernan JR, Kotov DI, Martinov T, Osum KC, Ruggiero JL, Rust BJ, Landry SJ, Jenkins MK, McLachlan JB, Fife BT.
Nat Commun. 2016 Jun 13;7:11804. doi: 10.1038/ncomms11804.
PMID: 27292946

Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus.
Lee JR, Haddon DJ, Wand HE, Price JV, Diep VK, Hall DA, Petri M, Baechler EC, Balboni IM, Utz PJ, Wang SX.
Sci Rep. 2016 Jun 9;6:27623. doi: 10.1038/srep27623.
PMID: 27279139

Regulatory T Cells: A Crisis Averted.
Malhotra D, Jenkins MK.
Immunity. 2016 May 17;44(5):1079-81. doi: 10.1016/j.immuni.2016.04.025.
PMID: 27192571

Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response.
Reese TA, Bi K, Kambal A, Filali-Mouhim A, Beura LK, Bürger MC, Pulendran B, Sekaly RP, Jameson SC, Masopust D, Haining WN, Virgin HW.
Cell Host Microbe. 2016 May 11;19(5):713-9. doi: 10.1016/j.chom.2016.04.003. Epub 2016 Apr 20.
PMID: 27107939

Normalizing the environment recapitulates adult human immune traits in laboratory mice.
Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D.
Nature. 2016 Apr 28;532(7600):512-6. doi: 10.1038/nature17655. Epub 2016 Apr 20.
PMID: 27096360

Spontaneous partial loss of the OT-I transgene.
Pritchard GH, Cross EW, Strobel M, Jameson SC, Kedl RM, Hogquist KA, Hunter CA.
Nat Immunol. 2016 Apr 19;17(5):471. doi: 10.1038/ni.3411. No abstract available.
PMID: 27092794

Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling.
Xing Y, Wang X, Jameson SC, Hogquist KA.
Nat Immunol2016 May;17(5):565-73. doi: 10.1038/ni.3419. Epub 2016 Apr 4.
PMID: 27043411

IL-15-Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T Cells.
Schenkel JM, Fraser KA, Casey KA, Beura LK, Pauken KE, Vezys V, Masopust D.
J Immunol. 2016 May 1;196(9):3920-6. doi: 10.4049/jimmunol.1502337. Epub 2016 Mar 21.
PMID: 27001957

Kalekar LA, Schmiel SE, Nandiwada SL, Lam WY, Barsness LO, Zhang N, Stritesky GL, Malhotra D, Pauken KE, Linehan JL, O'Sullivan MG, Fife BT, Hogquist KA, Jenkins MK, Mueller DL.
Nat Immunol. 2016 Mar;17(3):304-14. doi: 10.1038/ni.3331. Epub 2016 Feb 1.
PMID: 26829766

Shortened Intervals during Heterologous Boosting Preserve Memory CD8 T Cell Function but Compromise Longevity.
Thompson EA, Beura LK, Nelson CE, Anderson KG, Vezys V.
J Immunol. 2016 Apr 1;196(7):3054-63. doi: 10.4049/jimmunol.1501797. Epub 2016 Feb 22.
PMID: 26903479

Anti-Insulin Immune Responses Are Detectable in Dogs with Spontaneous Diabetes.
Kim JH, Furrow E, Ritt MG, Utz PJ, Robinson WH, Yu L, Eckert A, Stuebner K, O'Brien TD, Steinman L, Modiano JF.
PLoS One. 2016 Mar 31;11(3):e0152397. doi: 10.1371/journal.pone.0152397. eCollection 2016.
PMID: 27031512

First microbial encounters.
Khoruts A.
Nat Med. 2016 Mar;22(3):231-2. doi: 10.1038/nm.4042. Epub 2016 Feb 1.
PMID: 26828194

Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.
Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyártó BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH.
Nat Immunol. 2016 Feb 22. doi: 10.1038/ni.3396. Epub 2016 Feb 22.
PMID: 26901152

Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns.
Malhotra D, Linehan JL, Dileepan T, Lee YJ, Purtha WE, Lu JV, Nelson RW, Fife BT, Orr HT, Anderson MS, Hogquist KA, Jenkins MK.
Nat Immunol. 2016 Feb;17(2):187-95. doi: 10.1038/ni.3327. Epub 2016 Jan 4.
PMID: 26726812

Arthritis in KRN T cell receptor transgenic mice does not require interleukin-17 or Th17 cells.
Auger JL, Cowan HM, Engelson BJ, Kashem SW, Prinz I, Binstadt BA.
Arthritis Rheumatol. 2016 Feb 16. doi: 10.1002/art.39646. [Epub ahead of print]
PMID: 26882006

Fractionated radiotherapy combined with PD-1 pathway blockade promotes CD8 T cell-mediated tumor clearance for the treatment of advanced malignancies.
Martinov T, Fife BT.
Ann Transl Med. 2016 Feb;4(4):82. doi: 10.3978/j.issn.2305-5839.2016.01.13.
PMID: 27004229

Colonoscopic screening shows increased early incidence and progression of adenomas in cystic fibrosis.
Niccum DE, Billings JL, Dunitz JM, Khoruts A.
J Cyst Fibros. 2016 Feb 2. pii: S1569-1993(16)00009-6. doi: 10.1016/j.jcf.2016.01.002. [Epub ahead of print]
PMID: 26851188

Fas ligand based immunotherapy: A potent and effective neoadjuvant with checkpoint inhibitor properties, or a systemically toxic promoter of tumor growth?
Modiano JF, Bellgrau D.
Discov Med. 2016 Feb;21(114):109-16. Review.
PMID: 27011046

Most microbe-specific naïve CD4⁺ T cells produce memory cells during infection.
Tubo NJ, Fife BT, Pagan AJ, Kotov DI, Goldberg MF, Jenkins MK.
Science. 2016 Jan 29;351(6272):511-4. doi: 10.1126/science.aad0483.
PMID: 26823430

Changes in Colonic Bile Acid Composition following Fecal Microbiota Transplantation Are Sufficient to Control Clostridium difficile Germination and Growth.
Weingarden AR, Dosa PI, DeWinter E, Steer CJ, Shaughnessy MK, Johnson JR, Khoruts A, Sadowsky MJ.
PLoS One. 2016 Jan 20;11(1):e0147210. doi: 10.1371/journal.pone.0147210. eCollection 2016.
PMID: 26789728

Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation.
Benck CJ, Martinov T, Fife BT, Chatterjea D.
J Vis Exp. 2016 Jan 25;(107). doi: 10.3791/53638.

Interleukin-2-Dependent Allergen-Specific Tissue-Resident Memory Cells Drive Asthma.
Hondowicz BD, An D, Schenkel JM, Kim KS, Steach HR, Krishnamurty AT, Keitany GJ, Garza EN, Fraser KA, Moon JJ, Altemeier WA, Masopust D, Pepper M.
Immunity. 2016 Jan 19;44(1):155-66. doi: 10.1016/j.immuni.2015.11.004. Epub 2015 Dec 29.
Selective programming of CCR10+ innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation.
Yang J, Hu S, Zhao L, Kaplan DH, Perdew GH, Xiong N.
Nat Immunol. 2016  Jan;17(1):48-56, doi: 10.1038/ni.3312. [Epub 2015 Nov2]

Regulatory T Cell Induction and Retention in the Lungs Drives Suppression of Detrimental Type 2 Th Cells During Pulmonary Cryptococcal Infection.
Wiesner DL, Smith KD, Kotov DI, Nielsen JN, Bohjanen PR, Nielsen K.
J Immunol. 2016 Jan 1;196(1):365-74. doi: 10.4049/jimmunol.1501871. [Epub 2015 Nov 20.]

Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity.
Danahy DB, Strother RK, Badovinac VP, Griffith TS.
Crit Rev Immunol. 2016;36(1):57-74. doi: 10.1615/CritRevImmunol.2016017098. Review.
PMID: 27480902