Jesse Williams, PhD
Assistant Professor, Integrative Biology & Physiology,
Assistant Professor, Integrative Biology & Physiology
Faculty, PhD Program in Integrative Biology and Physiology
Faculty, Microbiology, Immunology and Cancer Biology (MICaB) Ph.D. Graduate Program
Preceptor, Medical Scientist Training Program (Combined MD/PhD Training Program)
Postdoctoral Fellowship, Division of Pathology and Immunology, Washington University in St. Louis, 2019
PhD, Molecular Pathology and Molecular Medicine/Immunology, University of Chicago, 2013
BA, DePauw University, 2007
Summary
Awards & Recognition
International Conference on Lipid and Atherosclerosis (ICoLA), Best Oral Presentation, 2018 American Heart Association, Postdoctoral Fellowship, 2016 Robert E. Priest Fellowship, University of Chicago, Department of Pathology, 2012
Research
Research Summary/Interests
My lab is interested in understanding the contribution of myeloid cells in the pathogenesis of metabolic and cardiovascular diseases, like atherosclerosis. We aim to determine mechanisms regulating the development and function of tissue-resident macrophages, as well as fate-decisions of circulating monocytes upon entry into inflamed tissues.
Research Funding Grants
NIH, National Heart, Lung, and Blood Institute K99/R00 HL138163 “Atherosclerotic Lesion Initiation by Resident Aortic Macrophage Proliferation and Lipid Uptake”
Publications
Williams, J. W., Zaitzev, K., Kim, K.-w., Ivanov, S., Saunders, B., Kim, K., Elvington, A., Schrank, P. R., Wohltmann, M., Epelman, S., Artyomov, M., Lavine, K., Zinselmeyer, B., Choi, J.-H., & Randolph, G. J. (2020). Limited Proliferation Capacity of Aorta Intima Resident Macrophages Requires Monocyte Recruitment for Atherosclerotic Plaque Progression. Nature Immunology, 21(10), 1194-1204.
Williams, J. W., Huang, L.-h., & Randolph, G. J. (2019). Cytokine Circuits in Cardiovascular Disease. Immunity, 50(4), 941--954.
Williams, J. W., Martel, C., Potteaux, S., Esaulova, E., Ingersoll, M. A., Elvington, A., Saunders, B. T., Huang, L.-H., Habenicht, A. J., Zinselmeyer, B. H., & others (2018). Limited Macrophage Positional Dynamics in Progressing or Regressing Murine Atherosclerotic Plaques—brief report. Arteriosclerosis, thrombosis, and vascular biology (ATVB), 38(8), 1702—1710
Williams, J. W., Giannarelli, C., Rahman, A., Randolph, G. J., & Kovacic, J. C. (2018). Macrophage Biology, Classification, and Phenotype in Cardiovascular Disease: JACC Macrophage in CVD Series (part 1). Journal of the American College of Cardiology, 72(18), 2166--2180
Williams, J. W., Elvington, A., Ivanov, S., Kessler, S., Luehmann, H., Baba, O., Saunders, B. T., Kim, K.-W., Johnson, M. W., Craft, C. S., & others (2017). Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood. Circulation Research, 121(6), 662--676.