Jesse Williams, PhD
Assistant Professor, Integrative Biology & Physiology,
Assistant Professor, Integrative Biology & Physiology
Postdoctoral Fellowship, Division of Pathology and Immunology, Washington University in St. Louis, 2019
PhD, Molecular Pathology and Molecular Medicine/Immunology, University of Chicago, 2013
BA, DePauw University, 2007
Awards & Recognition
International Conference on Lipid and Atherosclerosis (ICoLA), Best Oral Presentation, 2018 American Heart Association, Postdoctoral Fellowship, 2016 Robert E. Priest Fellowship, University of Chicago, Department of Pathology, 2012
International Conference on Lipid and Atherosclerosis (ICoLA), Best Oral Presentation, 2018
American Heart Association, Postdoctoral Fellowship, 2016
Robert E. Priest Fellowship, University of Chicago, Department of Pathology, 2012
My lab is interested in understanding the contribution of myeloid cells in the pathogenesis of metabolic and cardiovascular diseases, like atherosclerosis. We aim to determine mechanisms regulating the development and function of tissue-resident macrophages, as well as fate-decisions of circulating monocytes upon entry into inflamed tissues.
Research Funding Grants
NIH, National Heart, Lung, and Blood Institute K99/R00 HL138163 “Atherosclerotic Lesion Initiation by Resident Aortic Macrophage Proliferation and Lipid Uptake”
Williams J, Martel C, Potteaux S, Esaulova E, Ingersoll M, Elvington A, Saunders B, Huang L, Habenicht A, Zinselmeyer B, Randolph G. Limited macrophage positional dynamics in progressing or regressing murine atherosclerotic plaques. Arteriosclerosis, Thrombosis, and Vascular Biology, 2018; 38:1702–1710.
Williams J, Giannarelli C, Rahman A, Randolph G, Kovacic J. The Macrophage in Cardiovascular Disease, Part 1: Macrophage Biology, Classification, and Phenotype. Journal of the American College of Cardiology. 2018; 72, 18.
Williams J, Elvington A, Ivanov S, Kessler S, Luehmann H, Baba O, Saunders B, Kim KW, Johnson M, Craft C, Choi J, Sorci-Thomas M, Zinselmeyer B, Brestoff J, Liu Y, Randolph G. Thermoneutrality but not UCP1 deficiency suppresses monocyte mobilization into the blood. Circulation Research. 2017; 1; 121(6): 662-676.
Kim K, Williams J, Wang Y, Ivanov S, Colonna M, Murphy K, Randolph G. MHC II+ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes. Journal of Experimental Medicine. 2016 Sep 19;213(10): 1951-9.
Williams J, Elvington A, Kessler S, Wohltmann M, Wu G, Randolph GJ. MHC II antigen presentation by B cells is dispensable for atherosclerotic lesion development. ImmunoHorizons, 2019; In Press.