Geoffrey Hart, PhD

Assistant Professor, Division of Infectious Diseases and International Medicine

Geoffrey Hart

Contact Info

Mailing Address:
689 SE 23rd Avenue
MC2821 Room 2-103
Microbiology Research Facility
Minneapolis, MN 55455

Lab Address:
689 SE 23rd Avenue
MC2821 Room 2-133
Microbiology Research Facility
Minneapolis, MN 55455

Administrative Assistant Name
Becca Johnson

Administrative Phone

Administrative Email

Administrative Fax Number

Fellowship, Malaria Research Program, NIAID, NIH

PhD, University of Minnesota, Minneapolis, MN


    Dr. Hart performed his dissertation research in the Center for Immunology at the University of Minnesota. Postdoctoral work at the NIH has focused on malaria research. His primary interest is centered on innate immunity, particularly NK cells, in malaria. Using a basic immunology approach, he collaborates with on-going studies in malaria endemic regions of Africa to try to understand protective and pathological mechanisms of this deadly disease.


    • Human innate Immunology
    • Natural Killer cells
    • Infectious Disease
    • Malaria


    Research Summary/Interests

    • Basic human immunology
    • Malaria immunity and pathogenesis
    • Antibody mediated immunity
    • Innate inflammation regulation

    Human immunology of malaria
    There is no approved vaccine for malaria, and there are still many fundamental unanswered questions for malaria immunity. The Hart lab believes many of these unanswered questions lie where innate immunity intersects with the adaptive immune system. Using a basic immunology approach, they collaborate with on-going studies in malaria endemic regions of Africa. Current malaria projects center around understanding the mechanism of antibody mediated immunity and innate regulatory mechanisms (or lack thereof) in pathological immune responses. We use human subject samples primarily for our studies, and we are also developing novel mouse models to better understand in vivo dynamics where needed.

    Dr. Hart is a new Primary Investigator in the MICaB program and is excited to train and mentor the next generation of MICaB graduate students. Rotation spots are currently available for the 2017 incoming class. Please apply via email (


    • Hart GT*, Tran TM, Theorell J, Schlums H, Arora G, Rajagopalan S, Sangala ADJ, Welsh KJ, Traore B, Pierce SK, Crompton PD, Bryceson YT, Long EO* Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria. Journal of Experimental Medicine. ePub Apr 12, June 3 issue; 216(6). * = co-corresponding author.
    • Arora G, Hart GT, Manzella-Lapeira J, Doritchamou JY, Narum DL, Thomas LM, Brzostowski J, Rajagopalan S, Doumbo OK, Traore B, Miller LH, Pierce SK, Duffy PE, Crompton PD, Desai SA, Long EO. NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity. Elife. 2018 Jun 26;7. pii: e36806.
    • Burrack KS, Huggins MA, Taras E, Dougherty P, Henzler CM, Yang R, Alter S, Jeng EK, Wong HC, Felices M, Cichocki F, Miller JS, Hart GT, Johnson AJ, Jameson SC, Hamilton SE. Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells. Immunity. 2018 Apr 17;48(4):760-772.e4.
    • Hart, G.T., Akkaya, M., Chida, A.S., Wei, C., Jenks, S.A., Tipton, C., He, C., Wendel, B.S., Skinner, J., Arora, G., Kayentao, K., Ongoiba, A., Doumbo, O., Traore, B., Narum, D.L., Jiang, N., Crompton, P.D., Sanz, I., and Pierce S.K. 2016 The Regulation of Inherently Autoreactive VH4-34+ Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa. Journal of Immunology 197 (10).
    • Gordon E.B., Hart G.T. (co-first), Tran T.M.,Waisberg M., Akkaya M., Kim, A.S., Hamilton, S.E., Pena M., Yazew T., Qi C.F., Lee, C., Lo, Y., Miller L.H., Powell, J.D., Pierce S.K. 2015. Targeting glutamine metabolism rescues mice from late-stage cerebral malaria. PNAS (ePub Oct. 5th, 2015)
    • Gordon E.B., Hart G.T. (co-first), Tran T.M., Waisberg M., Akkaya M., Skinner J., Zinöcker S., Pena M., Yazew T., Qi C.F., Miller L.H., Pierce S.K. 2015 Inhibiting the Mammalian target of rapamycin blocks the development of experimental cerebral malaria. mBio 6:e00725.
    • Crompton, P.D., Moebius, J., Portugal, S., Waisberg, M., Hart, G., Garver, L.S., Miller, L.H., Barillas-Mury, C., Pierce, S.K. 2014 Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease. Annual Reviews in Immunology 32:157-87.
    • Hart, G. T., Peery, S. L., Hamilton, S. E., Jameson, S. C. 2012. Cutting Edge: Kruppel-like Factor 2 Is Required for Phenotypic Maintenance but Not Development of B1 B Cells. Journal of Immunology 189: 3293-7.
    • Hart, G. T., Hogquist, K. A., Jameson, S. C. 2012. KLF transcription factors in lymphocytes. Journal of Immunology 189: 521-6.
    • Hart, G. T., Wang, X., Hogquist, K. A., and Jameson S. C.,2011. KLF2 regulates B cell reactivity, subset differentiation, and trafficking molecule expression. PNAS 108:716-21.
    • Takada, K., Wang, X., Hart, G. T., Odumade, O. A., Weinreich, M. A., Hogquist, K. A., and Jameson, S. C. 2011. KLF2 is required for trafficking but not quiescence in post-activated T cells. Journal of Immunology 186:775-83.


    Teaching Areas

    • Immunology
    • Cellular and Molecular Biology


    Clinical Interests

    Vaccine development; Immunotherapy