Mescher Lab Research Associate Alumni

Senior Research Associate 1992-2016
Laboratory of Dr. Matthew Mescher

Research Emphasis/Pubications:  Autocrine IFN-γ promotes naive CD8 T cell differentiation and synergizes with IFN-α to stimulate strong function.,Inflammatory cytokines as a third signal for T cell activation., Signal 3 availability limits the CD8 T cell response to a solid tumor., Molecular basis for checkpoints in the CD8 T cell response: tolerance versus activation., Signal 3 tolerant CD8 T cells degranulate in response to antigen but lack granzyme B to mediate cytolysis.,CD8 T cell clonal expansion and development of effector function require prolonged exposure to antigen, costimulation, and signal 3 cytokine. List of all Publications

Current Position:  Coordinator of Translational Therapy Laboratory (TTL)., University of Minnesota Medical School, Minneapolis, MN
Contact Info: curts001@umn.edu