Masopust Lab

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The Masopust Lab

Graduate Students and Post Doctoral Fellows in the lab are working on research that is focused on CD8 and CD4 T cell responses to a variety of viral and bacterial infections to help understand the development of immunological protection from re-infection. We observe and manipulate pathogen specific T cell responses over time by using MHC tetramers, adoptive transfer of transgenic T cells, fluorescence flow cytometry and sorting, and gene microarry analysis. Upon activation in lymphoid tissue, rare pathogen-specific naïve T cells proliferate, acquire effector functions, disseminate throughout the organism, and contribute to the eradication of pathogens. In situations where antigen is successfully eliminated, most effector T cells die by apoptosis. However, a fraction of effector T cells escape death and differentiate into long-lived memory T cells that contribute to protective immunity. We are currently dedicated to elucidating the developmental cues that govern T cell migration to different anatomical locations, commitment to the memory lineage, and the contribution of memory T cell differentiation state and location to protection from re-infection. Memory T cells that reside at common portals of pathogen entry or infection, especially the intestinal mucosa, are of particular interest. By understanding these issues, we hope to contribute to the development of better vaccination strategies, and are currently focused on informing development of a protective HIV vaccine.

View publications here.

Looking for current Masopust-Vezys Lab Info or Graduate Students, Post Doctoral Fellows or Research Associates?  click here

 

Graduate Students

Kristin Anderson, Ph.D.

kristin

Program: MICaB
Defense Year: 2014
Advisor: Dave Masopust
Dissertation Title: "Essential Discrimination of Vascular and Tissue Lymphocytes Redefines CD8 T Cell Responses to Respiratory Infection"

Current PositionPostdoctoral Fellow, Fred Hutchinson Cancer Research Center (Phil Greenberg lab), Seattle, WA
Contact Info: kganders@fhcrc.org 


Jason Schenkel, M.D., Ph.D.

jason

Program: MICaB
Defense Year: 2014
Advisor: Dave Masopust
Dissertation Title: "The Distribution and Function of Resident Memory CD8 T Cells"

Current PositionResident (Clinical Pathology), Brigham & Women's Hospital, Boston, MA
Contact Info: schen168@umn.edu


Elizabeth Steinert, Ph.D.

steinertProgram: MICaB
Defense Year: 2016
Advisor: Dave Masopust
Dissertation Title: "Evaluating memory CD8 T Cell quantity, distribution and migration."

Current Position:Postdoctoral fellow (Navdeep Chandel lab), Northwestern University, Chicago, IL
Contact Info:
stein500@umn.edu
 

 

Post Doctoral Fellows

Kerry Casey, Ph.D.

casey 
Fellowship dates: 2008-2010
Research Emphasis: Utilized a series of cutting-edge technologies characterizing migration patterns and quantification and longevity of pathogen specific T cell memory. Work resulted in thevlaunch of a new field of CD8 T cell research, tissue-resident memory formation, and the first mechanistic description of memory T cell retention at mucosal sites.Challenged dogmatic beliefs in the differences in the immune systems of mice and men through the capture and immunophenotyping of wild mice showing that stimulation history and not genetics drives many of the observed discrepancies.

Current Position: Scientist II at MedImmune, Washington D.C.
Contact Info: caseyk@medimmune.com 
 

 

Luke Manlove, Ph.D.

luke m

Fellowship dates: 2015-2016
Research Emphasis:Heterologous Vaccination and Checkpoint Blockade Synergize To Induce Antileukemia Immunity. For a full list of publications

Current Position: Scientist Seattle Genetics, Seattle Washington
Contact Info: manl0039@umn.edu 
 

 

Research Associates

Kathryn Fraser, Ph.D.

fraser   
Research Associate 2008-2015
Laboratory of David Masopust

Research Emphasis/PublicationsPreexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting.T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses. full list of Publications

Current Position: Senior Scientist, Biothera, Minneapolis, MN
Current Info: fraser.katy@gmail.com 
 

 

Masopust-Vezys Labs, Summer 2016
Bottom (L-R): C.Nelson, E.Steinhert, R.Fonesca, E.Thompson, C.Quarnstrom, P.Rosato
Middle (L-R): L.Manlove, L.Beura, D.Masopust, V.Vezys, O.Adam, A.Soerens
Back: T.Heim