Kaplan Lab

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The Kaplan Lab

Graduate Students and Post Doctoral Fellows in the lab worked on understanding Dendritic cells (DC) which are professional antigen presenting cells found in skin, other peripheral tissues and in secondary lymphoid organs that are uniquely efficient at initiating T cell responses. The DC paradigm holds that tissue DC migrate to regional LN where they present antigen acquired in the periphery to T cells resulting in either a productive adaptive response or tolerance depending on the activation state of the DC. In the skin at steady-state there are at least 3 well-defined distinct subsets of DC that can be distinguished based on location, ontogeny and expression specific markers: Langerhans cells (LC), CD103+ dermal DC (dDC) and CD11b+ dDC.  Why there are so many DC subsets and the contribution each one makes to the development of cutaneous adaptive immune responses is a primary focus of the lab.

View publications here.

Graduate Students

Sakeen Kashem, Ph.D.

sakeen

Program: MICaB
Defense Year: 2016
Advisor: Dan Kaplan
Dissertation Title: "Immunity Against Candida albicans Skin Infections"

Current Position Medical Student, University of Minnesota Medical School, Minneapolis, MN
Contact Infokashe007@umn.edu 


Nathan Welty, M.D., Ph.D.

welty

Program: MICaB
Defense Year: 2014
Advisor: Dan Kaplan
Dissertation Title: "In Vivo Functions of Intestinal Dendritic Cells"

Current Position Resident (Internal Medicine, PSTP), University of Pennsylvania, Philadelphia, PA
Contact Infowelt0123@umn.edu 

Post Doctoral Fellows

Aleh Bobr, M.D.

aleh

Fellowship dates: 2008-2012
Research Emphasis
:Autocrine/paracrine TGF-β1 inhibits Langerhans cell migration.Full list of publications

Current Position: Resident, Research Year, Anatomic and Clinical Pathology Residency, Mayo Clinic, Rochester, MN


 

Botond Igyártó, Ph.D.

botond

Fellowship dates: 2008-2012
Research Emphasis
:  Discovery and Characterization of New Dendritic Cell Subsets, Define Roles for Skin Dendritic Cell Subsets in Inflammatory Settings, Determine the Role of Skin Dendritic Cell Subsets in Steady-State. Full list of publications

Current Position: Assistant Professor/Assistant Investigator at Baylor Institute for Immunology Research, Dallas/Fort Worth, TX
Contact Info: Botond.Igyarto@baylorhealth.edu 
 

 

Felix Scholz, Ph.D.

felix

Fellowship dates: 2010-2014
Research EmphasisLangerhans Cells Suppress CD49a+ NK Cell–Mediated Skin Inflammation

Current Position: Immunologist, Pharmasan, Osceola, WI

 

Research Associates

 

Javed Mohammed, Ph.D.

javed

Research Associate 2012-2016
Laboratory of Dan Kaplan

Research Emphasis/Publications: Explore therapeutic strategies targeting TGFβ1 activating integrins αvβ6 and αvβ8 for various pathologies associated with tissue inflammation, fibrosis and autoimmunity.  Role of integrins αvβ6 and αvβ8 in epidermal dendritic cell migration and resident memory CD8 T cell development and maintenance in skin.  Interactions of keratinocyte subsets including hair follicle stem cells with hematopoietic cells.  Langerhans cell and resident memory CD8 T cell immunology and their role in skin pathology.  Full list of Publications   

Current PositionAssistant Professor, Dermatology, University of Minnesota, MN
Current Info: amohamme@umn.edu